A modified preparation (LMK03) of the oriental medicine Jangwonhwan reduces Aβ1–42 level in the brain of Tg-APPswe/PS1dE9 mouse model of Alzheimer disease

Seo, Jieun; Jung, Eun Young; Kim, Ji Hye; Lyu, Yeoung Su; Han, Pyung Lim; Kang, Hyung Won

doi:10.1016/j.jep.2010.05.055

Cited by 20 publications

(12 citation statements)

References 44 publications

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“…Neuromol Med (2011) 13:197-203 201 mice) is different between our study and the study by Seo et al 2010, the Ab42 levels were similar. The median Ab40 and Ab42 levels in the rat hippocampus in the D group were both 2.7 times higher compared with those in the C group.…”

Section: Discussioncontrasting

confidence: 81%

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Occlusal Disharmony Increases Amyloid-β in the Rat Hippocampus

et al. 2011

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Amyloid-β plays a causative role in Alzheimer's disease. Occlusal disharmony causes chronic psychological stress, and psychological stress increases amyloid-β accumulation. The purpose of the present study was to investigate whether occlusal disharmony-induced psychological stress affects the accumulation of amyloid-β and its related gene expressions in the rat hippocampus. Eight-week-old male Wistar rats (n = 18) were divided into three groups of six rats each: (1) a control group that received no treatment for 8 weeks; (2) an occlusal disharmony group that underwent cutoff maxillary molar cusps for 8 weeks; and (3) a recovered group that underwent cutoff maxillary molar cusps for 4 weeks followed by recovery for 4 weeks. Occlusal disharmony increased plasma corticosterone levels in a time-dependent manner. Levels of amyloid-β 40 and 42, glucocorticoid receptor (Gr) protein, and cleaved caspase 3 (Casp3) as well as gene expressions of amyloid precursor protein, beta-secretase, Casp3, and Gr in the hippocampus in the occlusal disharmony group were significantly higher than those in the control group (P < 0.016). These findings were significantly improved by recovery of occlusion (P < 0.016). These results indicate that psychological stress induced by occlusal disharmony reversibly induces amyloid-β 40 and 42 in the rat hippocampus through the glucocorticoid signal.

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Section: Discussioncontrasting

confidence: 81%

“…In a transgenic mouse model of AD, the values of Ab40 and Ab42 were about 1,000 pmol/mg and 2,600 pmol/mg of brain (prefrontal cortex) using a similar method, respectively (Seo et al 2010). Although the area (hippocampus vs. prefrontal cortex) or species (rats vs. Fig.…”

Section: Discussionmentioning

confidence: 89%

Occlusal Disharmony Increases Amyloid-β in the Rat Hippocampus

et al. 2011

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“…TGase 2 (EC2.1.2.13) is a crosslinking enzyme that has been implicated in numerous cellular pathways, including cancer cell proliferation, migration, angiogenesis, epithelial mesenchymal transition and drug resistance (Verma and Mehta, 2007;Iismaa et al, 2009;Shao et al, 2009;Seo et al, 2010). A series of studies have shown that the induction of TGase 2 contributes to constitutive nuclear factor-kB (NF-kB) activation via polymerization of the inhibitor of NF-kB (Lee et al, 2004;Kim et al, 2006;Park et al, 2006), and that this is one of the mechanisms of drug resistance in cancer cells (Mehta et al, 2004;Herman et al, 2006;Kim et al, 2006Kim et al, , 2008Kim et al, , 2009Park et al, 2006;Gangadharan et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

“…Either case of TGase-2-mediated downregulation of inhibitor of NF-kB or peroxisome proliferator-activated receptor-g presents reducing suppressor of inflammatory transcription factors. We have proposed that TGase-2-mediated protein-protein crosslinking serves as a unique mechanism of secondary signaling through post-translational modification (Seo et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Cancer cells promote survival through depletion of the von Hippel–Lindau tumor suppressor by protein crosslinking

et al. 2011

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“…LMK03-Jangwonhwan has a potency to inhibit AD-like pathology at a detectable level, but LMK03 is not likely to retain the major ability of LMK02-Jangwonhwan to modify AD pathology in several AD related molecular parameters [134] 14. Cereboost Panax quinquefolius standardized to 10.65% ginsenosides Improvement in working memory performance, reaction time accuracy and calmness in healthy young volunteers [135] 15.…”

Section: Lmk03-jangwonhwan Poria Cocos; Angelica Gigasmentioning

confidence: 99%

Traditional Korean East Asian Medicines and Herbal Formulations for Cognitive Impairment

Kumar

Song

et al. 2013

Molecules

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Abstract:Hanbang, the Traditional Korean Medicine (TKM), is an inseparable component of Korean culture both within the country, and further afield. Korean traditional herbs have been used medicinally to treat sickness and injury for thousands of years. Oriental medicine reflects our ancestor's wisdom and experience, and as the elderly population in Korea is rapidly increasing, so is the importance of their health problems. The proportion of the population who are over 65 years of age is expected to increase to 24.3% by 2031. Cognitive impairment is common with increasing age, and efforts are made to retain and restore the cognition ability of the elderly. Herbal materials have been considered for this purpose because of their low adverse effects and their cognitive-enhancing or anti-dementia activities. Herbal materials are reported to contain several active compounds that have effects on cognitive function. Here, we enumerate evidence linking TKMs which have shown benefits in memory improvements. Moreover, we have also listed Korean herbal formulations which have been the subject of scientific reports relating to memory improvement.

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A modified preparation (LMK03) of the oriental medicine Jangwonhwan reduces Aβ1–42 level in the brain of Tg-APPswe/PS1dE9 mouse model of Alzheimer disease

Cited by 20 publications

References 44 publications

Occlusal Disharmony Increases Amyloid-β in the Rat Hippocampus

Occlusal Disharmony Increases Amyloid-β in the Rat Hippocampus

Cancer cells promote survival through depletion of the von Hippel–Lindau tumor suppressor by protein crosslinking

Traditional Korean East Asian Medicines and Herbal Formulations for Cognitive Impairment

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