A modified response of NAFLD patients with non-significant fibrosis in nutritional counseling according to GCKR rs1260326

Kaliora, Andriana C.; Kalafati, Ioanna Panagiota; Gioxari, Aristea; Diolintzi, Anastasia; Kokkinos, Alexandros; Dedoussis, George

doi:10.1007/s00394-017-1499-7

Cited by 11 publications

(4 citation statements)

References 28 publications

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“…Several studies have explored the interaction between GCKR rs1260326 variant and the environmental factors [74,76,77]. In an open-labeled and single-arm clinical trial, Kaliora et al demonstrated that T allele carriers respond better to nutritional intervention in terms of fasting blood glucose levels compared to non-carriers, in 44 overweight adults with NAFLD which have been received dietary counseling for six months [76]. For instance, whole-grain supplementation is associated with lower fasting glucose and insulin concentrations independently of demographics, other dietary and lifestyle factors and BMI [78].…”

Section: Gckr: a Potential Carbohydrates' Modulator To Improve Liver mentioning

confidence: 99%

Nutrition and Genetics in NAFLD: The Perfect Binomium

Meroni

Longo

Rustichelli

et al. 2020

IJMS

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Nonalcoholic fatty liver disease (NAFLD) represents a global healthcare burden since it is epidemiologically related to obesity, type 2 diabetes (T2D) and Metabolic Syndrome (MetS). It embraces a wide spectrum of hepatic injuries, which include simple steatosis, nonalcoholic steatohepatitis (NASH), fibrosis, cirrhosis and hepatocellular carcinoma (HCC). The susceptibility to develop NAFLD is highly variable and it is influenced by several cues including environmental (i.e., dietary habits and physical activity) and inherited (i.e., genetic/epigenetic) risk factors. Nonetheless, even intestinal microbiota and its by-products play a crucial role in NAFLD pathophysiology. The interaction of dietary exposure with the genome is referred to as 'nutritional genomics,' which encompasses both 'nutrigenetics' and 'nutriepigenomics.' It is focused on revealing the biological mechanisms that entail both the acute and persistent genome-nutrient interactions that influence health and it may represent a promising field of study to improve both clinical and health nutrition practices. Thus, the premise of this review is to discuss the relevance of personalized nutritional advices as a novel therapeutic approach in NAFLD tailored management.

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Section: Gckr: a Potential Carbohydrates' Modulator To Improve Liver mentioning

confidence: 99%

Nutrition and Genetics in NAFLD: The Perfect Binomium

Meroni

Longo

Rustichelli

et al. 2020

IJMS

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“…Of note, we first discovered that rs1260326-C in the GCKR gene was linked to waist circumference in the elderly Chinese Han population with lean NAFLD. This connection may be attributed to the disrupted glucose and lipid metabolism regulated by GCKR 31 , leading to abnormal waist circumference.…”

Section: Discussionmentioning

confidence: 99%

Waist circumference mediates the association between rs1260326 in GCKR gene and the odds of lean NAFLD

Zhang

et al. 2023

Sci Rep

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While non-alcoholic fatty liver disease (NAFLD) has been widely studied, the pathophysiology of lean NAFLD, the critical NAFLD subgroup, remains elusive. This study aimed to clarify the association between polymorphisms of GCKR, waist circumference, and the odds of lean NAFLD in the elderly Chinese Han population who live in the Zhangjiang community center of Shanghai, China. Three single nucleotide polymorphisms (SNPs), including rs1260326, rs780093, and rs780094, were genotyped in MassARRAY Analyzer. The association between SNPs with waist circumference in five genetic models was analyzed and rechecked by the logistic regression analysis. Mediation models were established to evaluate whether the waist circumstance can mediate the association between SNPs and lean NAFLD. In this study, the frequency of the C allele of rs1260326, rs780093, and rs780094 was significantly lower in lean NAFLD individuals than in lean non-NAFLD ones. The association between rs1260326 in GCKR and the odds of lean NAFLD was mediated via waist circumference after adjusting gender and age in the elderly Chinese Han population (β = 1.196, R2 = 0.043, p = 0.020). For the first time, this study examined the mediating effect of waist circumference on the association between rs1260326 in GCKR and the odds of lean NAFLD (β = 0.0515, 95% CI 0.0107–0.0900, p = 0.004). It may contribute to illustrating the pathogenesis of lean NAFLD and indicate that waist circumference management might improve lean NAFLD control.

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“…Другим же его проявлением является влияние на уровень глюкозы и СРБ (С-реактивный белок) в крови, полиморфизм rs780094 способствует снижению показателей глюкозы, но приводит к повышению провоспалительного маркера СРБ у всех носителей аллеля ТТ вне зависимости от наличия НАЖБП [34,35]. При этом носительство мутантного полиморфизма rs1260326 способствует повышению уровня глюкозы в крови, который, однако, лучше корректируется диетой [36].…”

Section: влияние гена Gckr на развитие неалкогольной жировой болезни ...unclassified

Polymorphisms of HSD17B13, GCKR, HFE, and CP as factors of the development of non-alcoholic fatty liver disease and comorbid diseases

Смирнова

Lagutinskaya

2023

Medicinskij sovet

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Currently, non-alcoholic fatty liver disease is one of the most common chronic liver diseases. In recent years, this condition has been considered as a hepatic manifestation of the metabolic syndrome, which is associated with overweight and impaired glucose and fat metabolism. Despite the obvious role of lifestyle in the development of this disease, it is increasingly being suggested that disorders in the metabolism of fats and carbohydrates have a genetic basis, which determines the tendency to develop NAFLD. Mutant polymorphisms of the HSD17B13, GCKR, HFE, and CP genes have been shown to affect the course of NAFLD, but these effects require further study. Therefore, the aim of this work was to analyze and systematize the available data from foreign articles over the past 10 years. In this study, 573 articles were analyzed, the most important 64 original research works were used here. Mutations in the HSD17B13 gene are associated with a milder course of NAFLD, while GCKR gene polymorphisms, on the contrary, are associated with more severe histological manifestations of this disease, such as steatosis and fibrosis. The HFE and CP genes, although not directly related to macronutrient metabolism, nevertheless contribute to the development of more severe forms of NAFLD, which may be associated with the development of inflammation and oxidative stress caused by excessive accumulation of iron in hepatocytes.

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A modified response of NAFLD patients with non-significant fibrosis in nutritional counseling according to GCKR rs1260326

Cited by 11 publications

References 28 publications

Nutrition and Genetics in NAFLD: The Perfect Binomium

Nutrition and Genetics in NAFLD: The Perfect Binomium

Waist circumference mediates the association between rs1260326 in GCKR gene and the odds of lean NAFLD

Polymorphisms of <i>HSD17B13</i>, <i>GCKR</i>, <i>HFE</i>, and <i>CP</i> as factors of the development of non-alcoholic fatty liver disease and comorbid diseases

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