A moldable hydrogel based on sericin and Zn2+/F- dual-doped hydroxyapatite promotes skull defect repair through the synergistic effects of immunoregulation, enhanced angiogenesis and osteogenesis

Yao, Jiaxin; Huang, Changjin; Yao, Jialing; Hui, Junfeng; Shen, Shihong; Zheng, Xiaoyan; Shen, Lixin; Fan, Daidi

doi:10.1016/j.cej.2024.151789

Chemical Engineering Journal

2024

DOI: 10.1016/j.cej.2024.151789

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A moldable hydrogel based on sericin and Zn2+/F- dual-doped hydroxyapatite promotes skull defect repair through the synergistic effects of immunoregulation, enhanced angiogenesis and osteogenesis

Jiaxin Yao,

Changjin Huang,

Jialing Yao

et al.

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Cited by 4 publications

References 77 publications

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Visible Light‐Sensitive Sustainable Quantum Dot Crystals of Co/Mg Doped Natural Hydroxyapatite Possessing Antimicrobial Activity and Biocompatibility

Maleki‐Ghaleh,

Kamiński,

Moradpur‐Tari

et al. 2024

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Cutting‐edge research in advanced materials is increasingly turning toward the development of novel multifunctional nanomaterials for use in high‐tech applications. This research uses the solid‐state method as a solvent‐free technique to create multifunctional quantum dot (QD) hydroxyapatite (HA) crystals from bovine bone waste. By incorporating cobalt (Co) and magnesium (Mg) into the HA structure, the crystallinity of the hexagonal HA nanoparticles (99.7%), showing QD crystals is enhanced. Oxygen vacancies on the surfaces of the HA nanoparticles contributed to their bandgap falling within the visible light range. In addition, the dopants substituted calcium in the HA crystal structure and generated a divalent oxidation state, shifting the bandgap of natural HA toward red wavelengths (3.26 to 1.94 eV). Moreover, the incorporation of Co led to magnetization within the HA structure through spin polarization. Additionally, the doped QD crystals of HA nanoparticles showed significant antimicrobial activity against Escherichia coli, Staphylococcus aureus, and bacteriophages MS2, particularly under visible light exposure. In short, the Co/Mg co‐doped HA nanoparticles exhibited ferromagnetic properties, sensitivity to visible light, biocompatibility, and considerable antimicrobial effects, establishing their potential as sustainable multifunctional materials for biomedical applications, especially in anti‐infection treatments.

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Visible Light‐Sensitive Sustainable Quantum Dot Crystals of Co/Mg Doped Natural Hydroxyapatite Possessing Antimicrobial Activity and Biocompatibility

Maleki‐Ghaleh,

Kamiński,

Moradpur‐Tari

et al. 2024

Small

View full text Add to dashboard Cite

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Multifunctional hydrogel combined with electrical stimulation therapy for promoting diabetic wound healing

Zheng,

Yao,

Yao

et al. 2024

Nano Res.

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Multifunctional sericin-based biomineralized nanoplatforms with immunomodulatory and angio/osteo-genic activity for accelerated bone regeneration in periodontitis

Ming,

Li,

et al. 2025

Biomaterials

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A moldable hydrogel based on sericin and Zn2+/F- dual-doped hydroxyapatite promotes skull defect repair through the synergistic effects of immunoregulation, enhanced angiogenesis and osteogenesis

Cited by 4 publications

References 77 publications

Visible Light‐Sensitive Sustainable Quantum Dot Crystals of Co/Mg Doped Natural Hydroxyapatite Possessing Antimicrobial Activity and Biocompatibility

Visible Light‐Sensitive Sustainable Quantum Dot Crystals of Co/Mg Doped Natural Hydroxyapatite Possessing Antimicrobial Activity and Biocompatibility

Multifunctional hydrogel combined with electrical stimulation therapy for promoting diabetic wound healing

Multifunctional sericin-based biomineralized nanoplatforms with immunomodulatory and angio/osteo-genic activity for accelerated bone regeneration in periodontitis

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