A Molecular Dynamics Based Multi-scale Platelet Aggregation Model and Its High-Throughput Simulation

Xu, Zhipeng; Zou, Qingsong

doi:10.1007/978-3-030-96772-7_8

Cited by 1 publication

(2 citation statements)

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“…Xu et al . [ 10 ] proposed a multi-scale approach where fluid was simulated on the macro-scale using dissipative particle dynamics, and the fine-scale receptors’ biochemical reactions were modelled by coarse-grained molecular dynamics. Most of the macroscopic models are based on Computational Fluid dynamics (CFD) analysis, where convection-diffusion equations are solved to describe the interaction between blood flow and chemical or biological agents involved in thrombosis process [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

“…Zhang et al [8] and Gao et al [9] implemented a novel multiscale approach based on discrete particle methods to model thrombus formation in cardiovascular diseases by coupling the macroscopic flow conditions with cellular and molecular effects of platelet mechanical activation. Xu et al [10] proposed a multi-scale approach where fluid was simulated on the macro-scale using dissipative particle dynamics, and the fine-scale receptors' biochemical reactions were modelled by coarse-grained molecular dynamics. Most of the macroscopic models are based on Computational Fluid dynamics (CFD) analysis, where convection-diffusion equations are solved to describe the interaction between blood flow and chemical or biological agents involved in thrombosis process [11].…”

Section: Introductionmentioning

confidence: 99%

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Modelling of thrombus formation using smoothed particle hydrodynamics method

et al. 2023

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In this paper a novel model, based on the smoothed particle hydrodynamics (SPH) method, is proposed to simulate thrombus formation. This describes the main phases of the coagulative cascade through the balance of four biochemical species and three type of platelets. SPH particles can switch from fluid to solid phase when specific biochemical and physical conditions are satisfied. The interaction between blood and the forming blood clot is easily handled by an innovative monolithic FSI approach. Fluid-solid coupling is modelled by introducing elastic binds between solid particles, without requiring detention and management of the interface between the two media. The proposed model is able to realistically reproduce the thromboembolic process, as confirmed by the comparison of numerical results with experimental data available in the literature.

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Section: Introductionmentioning

confidence: 99%