A molecular epidemiological study targeting the glycoprotein gene of rabies virus isolates from China

Shao, Meng; Yan, Jiaxin; Xu, Guiyun; Nadin-Davis, Susan A.; Ming, Pinggang; Liu, Shengya; Wu, Jie; Ming, He-Tian; Zhu, Fengcai; Zhou, Dun-Jin; Xiao, Qi-You; Dong, Guojun; Yang, Xiaoming

doi:10.1016/j.virusres.2006.10.011

Cited by 42 publications

(44 citation statements)

References 50 publications

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“…14 Historical anecdotes suggest that Chinese RABVs might have been transferred to Indonesia and spread to each island via dogs accompanying human migrants in accord with the genetic data that supports a common origin for certain Chinese RABVs and viruses of Southeast Asia. 8,16,20 China-lineage C has a wide distribution, which is in agreement with previous studies. 8,21 Lineage F may originate in Southeast Asian nations, because the two isolates from Guangxi and Yunnan clustered with the RABVs from Cambodia, Thailand, and Malaysia.…”

Section: Fromsupporting

confidence: 93%

“…8,16,20 China-lineage C has a wide distribution, which is in agreement with previous studies. 8,21 Lineage F may originate in Southeast Asian nations, because the two isolates from Guangxi and Yunnan clustered with the RABVs from Cambodia, Thailand, and Malaysia. Guangxi is a convergent place for RABV isolates from the Indochina peninsula, Southeast Asia and Mainland China.…”

Section: Fromsupporting

confidence: 93%

“…Commodities, including animal trading, from Southeast Asian countries must pass through Guangxi before entering the mainland. 8,22 Our evolutionary estimation suggests that the Chinese RABVs in current circulation originated at about year 1115 AD, in accordance with a previous report. 14 This is inconsistent with records of dog rabies in China which trace the disease back at least 2000 years 1 ; Viral lineages that no longer circulate may have been responsible for those early outbreaks.…”

Section: Fromsupporting

confidence: 91%

“…15 China-lineages C and D were evolutionarily linked to RABVs from Indonesia and Thailand; the SN01-23 and HM65 isolates were located in a branch between lineages C and D. The Chinese CTN vaccine strain was categorized into lineage E, in close association with lineages F and D. Finally, China-lineage F clustered with the isolates from Cambodia, Thailand, and Malaysia. In comparison with previous studies on the phylogeny of Chinese RABVs, 8 two new China RABV lineages (B and F) were identified in this study.…”

Section: Phylogeny Of Chinese Rabvssupporting

confidence: 46%

See 3 more Smart Citations

Transmission dynamics of rabies in China over the last 40 years: 1969–2009

Shao

et al. 2010

Journal of Clinical Virology

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Section: Fromsupporting

confidence: 93%

Section: Fromsupporting

confidence: 93%

Section: Fromsupporting

confidence: 91%

Section: Phylogeny Of Chinese Rabvssupporting

confidence: 46%

See 2 more Smart Citations

Transmission dynamics of rabies in China over the last 40 years: 1969–2009

Shao

et al. 2010

Journal of Clinical Virology

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“…Phylogenetic relationships of 21 complete genome sequences of Lyssavirus Genotype 1 and five structural genes sequences of aG. The Phylogeny was inferred using an NJ method.research, the predicted G protein of the CTN vaccine strain and Chinese street rabies virus strains shared a high identity(10). Based on the complete genome sequences analysis alone, the SH06 isolate had 86.9% homology with the CTN vaccine strain but <82.6% with other vaccine strains at the nucleotide level.…”

mentioning

confidence: 99%

A comparison of complete genome sequences of a rabies virus chinese isolate SH06 with the vaccine strains

Shao

et al. 2009

Virol. Sin.

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Comparison of complete genome sequences of dog rabies viruses isolated from China and Mexico reveals key amino acid changes that may be associated with virus replication and virulence

Zhang

Zhong

et al. 2014

Arch Virol

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Rabies is a global problem, but its impact and prevalence vary across different regions. In some areas, such as parts of Africa and Asia, the virus is prevalent in the domestic dog population, leading to epidemic waves and large numbers of human fatalities. In other regions, such as the Americas, the virus predominates in wildlife and bat populations, with sporadic spillover into domestic animals. In this work, we attempted to investigate whether these distinct environments led to selective pressures that result in measurable changes within the genome at the amino acid level. To this end, we collected and sequenced the full genome of two isolates from divergent environments. The first isolate (DRV-AH08) was from China, where the virus is present in the dog population and the country is experiencing a serious epidemic. The second isolate (DRV-Mexico) was taken from Mexico, where the virus is present in both wildlife and domestic dog populations, but at low levels as a consequence of an effective vaccination program. We then combined and compared these with other full genome sequences to identify distinct amino acid changes that might be associated with environment. Phylogenetic analysis identified strain DRV-AH08 as belonging to the China-I lineage, which has emerged to become the dominant lineage in the current epidemic. The Mexico strain was placed in the D11 Mexico lineage, associated with the West USA-Mexico border clade. Amino acid sequence analysis identified only 17 amino acid differences in the N, G and L proteins. These differences may be associated with virus replication and virulence-for example, the short incubation period observed in the current epidemic in China.

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A molecular epidemiological study targeting the glycoprotein gene of rabies virus isolates from China

Cited by 42 publications

References 50 publications

Transmission dynamics of rabies in China over the last 40 years: 1969–2009

Transmission dynamics of rabies in China over the last 40 years: 1969–2009

A comparison of complete genome sequences of a rabies virus chinese isolate SH06 with the vaccine strains

Comparison of complete genome sequences of dog rabies viruses isolated from China and Mexico reveals key amino acid changes that may be associated with virus replication and virulence

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