A Molecular Epidemiology Project on Diet and Cancer: The Epic-Italy Prospective Study. Design and Baseline Characteristics of Participants

Palli, Domenico; Berrino, Franco; Víneis, Paolo; Tumino, Rosario; Panico, Salvatore; Masala, Giovanna; Saieva, Calogero; Salvini, Simonetta; Ceroti, Marco; Pala, Valeria; Sieri, Sabina; Frasca, Graziella; Giurdanella, Maria Concetta; Sacerdote, Carlotta; Fiorini, Laura; Celentano, Egidio; Galasso, Rocco; Decarli, Adriano; Krogh, Vittorio

doi:10.1177/030089160308900602

Cited by 125 publications

(106 citation statements)

References 18 publications

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“…The EnviroGenoMarkers (EGM) study15 is based on participants from two existing prospective cohorts: the Italian component of the European Prospective Investigation into Cancer and Nutrition (EPIC‐Italy)16 and the Northern Sweden Health and Disease Study (NSHDS) 17. In both cohorts, blood samples were (prospectively) collected from healthy subjects at enrolment.…”

Section: Methodsmentioning

confidence: 99%

“…Between 1993 and 1998, EPIC Italy completed the recruitment of 47,749 volunteers (15,171 men and 32,578 women, ages 35–70 years) in five different areas covered by cancer registries 16. After providing informed consent, a blood sample was collected as well as detailed information on dietary and life‐style habits using standardized questionnaires (http://epic.iarc.fr/research/quest.php).…”

Section: Methodsmentioning

confidence: 99%

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Pre‐diagnostic blood immune markers, incidence and progression of B‐cell lymphoma and multiple myeloma: Univariate and functionally informed multivariate analyses

Vermeulen¹,

Hosnijeh²,

Bodinier³

et al. 2018

Intl Journal of Cancer

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Recent prospective studies have shown that dysregulation of the immune system may precede the development of B‐cell lymphomas (BCL) in immunocompetent individuals. However, to date, the studies were restricted to a few immune markers, which were considered separately. Using a nested case–control study within two European prospective cohorts, we measured plasma levels of 28 immune markers in samples collected a median of 6 years before diagnosis (range 2.01–15.97) in 268 incident cases of BCL (including multiple myeloma [MM]) and matched controls. Linear mixed models and partial least square analyses were used to analyze the association between levels of immune marker and the incidence of BCL and its main histological subtypes and to investigate potential biomarkers predictive of the time to diagnosis. Linear mixed model analyses identified associations linking lower levels of fibroblast growth factor‐2 (FGF‐2 p = 7.2 × 10−4) and transforming growth factor alpha (TGF‐α, p = 6.5 × 10−5) and BCL incidence. Analyses stratified by histological subtypes identified inverse associations for MM subtype including FGF‐2 (p = 7.8 × 10−7), TGF‐α (p = 4.08 × 10−5), fractalkine (p = 1.12 × 10−3), monocyte chemotactic protein‐3 (p = 1.36 × 10−4), macrophage inflammatory protein 1‐alpha (p = 4.6 × 10−4) and vascular endothelial growth factor (p = 4.23 × 10−5). Our results also provided marginal support for already reported associations between chemokines and diffuse large BCL (DLBCL) and cytokines and chronic lymphocytic leukemia (CLL). Case‐only analyses showed that Granulocyte‐macrophage colony stimulating factor levels were consistently higher closer to diagnosis, which provides further evidence of its role in tumor progression. In conclusion, our study suggests a role of growth‐factors in the incidence of MM and of chemokine and cytokine regulation in DLBCL and CLL.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Pre‐diagnostic blood immune markers, incidence and progression of B‐cell lymphoma and multiple myeloma: Univariate and functionally informed multivariate analyses

Vermeulen¹,

Hosnijeh²,

Bodinier³

et al. 2018

Intl Journal of Cancer

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“…All exposure variables and the procedures to detect cancer incidence and mortality were performed as in the European investigation [48]. It is worth remembering that diet was assessed using semi-quantitative food frequency questionnaires designed to capture local dietary habits [44]. EPICOR is the cardiovascular diseases section of EPIC Italy; specific validated procedures to detect the incidence of coronary and cerebrovascular events were designed and applied [2,9,14,51].…”

Section: Mediterranean Dietary Patterns and Chronic Diseases In Recenmentioning

confidence: 99%

Mediterranean Dietary Pattern and Chronic Diseases

Panico

Mattiello

Panico

et al. 2013

Cancer Treatment and Research

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The study of the relationship between the Mediterranean way of eating and the occurrence of diseases typical of the economically developed countries has been considered the starting point of nutritional epidemiology. From the Seven Countries Study in the 1950s to the recent European EPIC collaboration, the evaluation of the components of diet-affecting chronic diseases such as cardiovascular disease and cancer has been crucially based on the analysis of foods and nutrients characterizing the Mediterranean dietary habits. This long research history has been marked by a consistency of data over time when either single nutrients/food groups or more complex dietary patterns have been analyzed: The Mediterranean way of eating is a protective tool from cardiovascular diseases and many cancers. Italy has been a natural point of observation, starting from cardiovascular disease in the mid-1950s and continuing with major cancers. In spite of unfavorable lifestyle changes in the Italian population mostly due to globalization of unhealthy habits (richer diet and lower levels of physical activity), those individuals still close to the Mediterranean style are significantly protected. The very recent Italian data derived from the observation of about 50,000 individuals, participating in the Italian cohorts of the EPIC study, confirm these findings and are consistent with results from other European populations and in some cases also from North American populations. Moreover, several dietary trials suggest that such a way of eating improves both the metabolic risk condition for chronic disease and the occurrence of those diseases. In conclusion, a way of eating inspired by a Mediterranean dietary pattern is not only based on evidence but is also a palatable style that has contributed to protection from the epidemic of chronic diseases.

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“…Information on drug use, including use of HRT, occupation and family history of cancer, had also been collected. 22 At follow-up. To take into account short-term variations in MBD, updated information on recent use of HRT, additional pregnancies, use of contraceptives or menopause in the 5-year period between enrolment and ME have been collected through a short mail questionnaire.…”

Section: Data Collectionmentioning

confidence: 99%

Dietary and lifestyle determinants of mammographic breast density. A longitudinal study in a Mediterranean population

Masala

Ambrogetti

Assedi

et al. 2006

Intl Journal of Cancer

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High mammographic breast density (H‐MBD) has been associated with increased breast cancer (BC) risk, even after adjustment for established BC risk factors. Only a few studies have examined the influence of diet on MBD. In a longitudinal study in Florence, Italy, we identified about 2,000 women with a mammogram taken 5 years after enrollment, when detailed information on dietary and lifestyle habits and anthropometric measurements had been collected. Original mammograms have been identified and retrieved (1,668; 83%), and MBD was assessed by 2 experienced readers, according to Wolfe's classification and a semiquantitative scale. By logistic analysis, we compared women with H‐MBD (P2 + DY according to Wolfe's classification) with those with low‐MBD (N1 + P1). H‐MBD was confirmed to be inversely associated with BMI, number of children and breast feeding, while it was directly associated with higher educational level, premenopausal status and a previous breast biopsy. In multivariate analyses adjusted for nondietary variables, H‐MBD was inversely associated with increasing consumption of vegetables (p for trend = 0.005) and olive oil (p for trend = 0.04). An inverse association was also evident between H‐MBD and frequent consumption of cheese and high intakes of β‐carotene, vitamin C, calcium and potassium (p for trend ≤ 0.05). On the other hand, we found a positive association with increasing consumption of wine (p for trend = 0.01). This large longitudinal study, the first carried out in Mediterranean women, suggests that specific dietary components may play a key role in determining MBD in this population, thus possibly modulating BC risk. © 2005 Wiley‐Liss, Inc.

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A Molecular Epidemiology Project on Diet and Cancer: The Epic-Italy Prospective Study. Design and Baseline Characteristics of Participants

Cited by 125 publications

References 18 publications

Pre‐diagnostic blood immune markers, incidence and progression of B‐cell lymphoma and multiple myeloma: Univariate and functionally informed multivariate analyses

Pre‐diagnostic blood immune markers, incidence and progression of B‐cell lymphoma and multiple myeloma: Univariate and functionally informed multivariate analyses

Mediterranean Dietary Pattern and Chronic Diseases

Dietary and lifestyle determinants of mammographic breast density. A longitudinal study in a Mediterranean population

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