A molecular mechanism for the stage specificity of the Drosophila prepupal genetic response to ecdysone

Woodard, Craig T.; Baehrecke, Eric H.; Thummel, Carl S.

doi:10.1016/0092-8674(94)90546-0

Cited by 205 publications

(158 citation statements)

References 40 publications

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“…bFtz-F1 is induced by an increase and a consequent decline of ecdysteroid titre (Sun et al 1994) and is likely to control genes acting in cuticle formation (Hiruma et al 1995). In Drosophila, bFtz-F1 is necessary for metamorphosis (Woodard et al 1994;Broadus et al 1999) and for activation of at least one pupal cuticle gene EDG84A (Murata et al 1996). The importance of bFtz-F1 for the larval moult is suggested by a rescue of ftz-f1 mutants with heat shock induction of bFtz-F1 around the moulting period (H. Ueda, personal communication).…”

Section: Nhr-25 As a Core Regulator Of Moultingmentioning

confidence: 99%

The conserved nuclear receptor Ftz‐F1 is required for embryogenesis, moulting and reproduction in Caenorhabditis elegans

Ishihara²,

et al. 2000

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Background: Nuclear receptors are essential players in the development of all metazoans. The nematode Caenorhabditis elegans possesses more than 200 putative nuclear receptor genes, several times more than the number known in any other organism. Very few of these transcription factors are conserved with components of the steroid response pathways in vertebrates and arthropods. Ftz-F1, one of the evolutionarily oldest nuclear receptor types, is required for steroidogenesis and sexual differentiation in mice and for segmentation and metamorphosis in Drosophila.

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Section: Nhr-25 As a Core Regulator Of Moultingmentioning

confidence: 99%

The conserved nuclear receptor Ftz‐F1 is required for embryogenesis, moulting and reproduction in Caenorhabditis elegans

Ishihara²,

et al. 2000

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“…[45][46][47][48][49][50] The ecdysone receptor complex, and the nuclear receptor competence factor bFTZ-F1, activate transcription of the early genes BR-C, E74A, and E93. 51,52 Salivary glands are not destroyed in animals with mutations in bFTZ-F1, BR-C, E74A, and E93. [52][53][54][55] While bFTZ-F1 and E93 mutants exhibit defects in vacuolar changes during salivary gland autophagic cell death, BR-C and E74A mutant salivary glands progress to a very late stage in cell death even though complete destruction is prevented.…”

Section: Activation Of Autophagic Cell Death In Drosophilamentioning

confidence: 99%

Autophagic programmed cell death in Drosophila

2003

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Autophagic programmed cell death occurs during the development of diverse animal groups, but the mechanisms that control this genetically regulated form of cell killing are poorly understood. Genetic studies of bulk protein degradation in yeast have provided important advances in our understanding of autophagy, and recent investigations of Drosophila autophagic cell death suggest that some of these mechanisms may be conserved. In Drosophila, several steroid-regulated genes that encode transcription regulators are required for autophagic cell death. These transcription regulators appear to activate a large number of genes that play a more direct role in cell killing, including genes that function in apoptosis such as caspases. While caspase function is required for autophagic cell death during Drosophila development, genes encoding proteins that are similar to the yeast autophagy regulators are also induced in dying salivary glands. Furthermore, numerous noncaspase proteases, cytoplasmic organizing factors, signaling molecules, and unknown factors are expressed in interesting patterns during autophagic cell death. This article reviews the current knowledge of the regulation of autophagic programmed cell death during development of Drosophila.

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“…Moreover, we detected no puff in the region 75CD, encompassing the locus containing the cell death genes rpr, hid and grim, and the bFTZ-F1 ecdysone regulated gene. 59,60 In wild-type salivary glands this puff appears during prepupal development (7 ± 9 h after puparium formation, see Becker 13 ). These findings indicate that expression of the suicide genes can occur without puff formation.…”

Section: Use Of Inhibitors or Activators Of Programmed Cell Death Revmentioning

confidence: 99%

The timing of Drosophila salivary gland apoptosis displays an l(2)gl-dose response

Farkas

Mechler

2000

Cell Death Differ

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A molecular mechanism for the stage specificity of the Drosophila prepupal genetic response to ecdysone

Cited by 205 publications

References 40 publications

The conserved nuclear receptor Ftz‐F1 is required for embryogenesis, moulting and reproduction in Caenorhabditis elegans

The conserved nuclear receptor Ftz‐F1 is required for embryogenesis, moulting and reproduction in Caenorhabditis elegans

Autophagic programmed cell death in Drosophila

The timing of Drosophila salivary gland apoptosis displays an l(2)gl-dose response

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