2009
DOI: 10.3354/dao02179
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A molecular perspective: biology of the emerging pathogen Batrachochytrium dendrobatidis

Abstract: Ten years after the first discovery of the chytrid pathogen Batrachochytrium dendrobatidis (Bd), the catastrophic effect of Bd on wild amphibian populations is indisputable. However, a number of persistent questions remain about Bd's origin and mechanisms of pathogenicity. Here we discuss the promise of genetic and genomic tools for answering these previously intractable questions about the biology and evolutionary history of Bd. Full genomes of 2 Bd strains have recently been sequenced, and Bd research on thi… Show more

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Cited by 30 publications
(29 citation statements)
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References 110 publications
(132 reference statements)
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“…Not succumbing to lethal chytridiomycosis infections may be explained by the host's biology (including host defenses, life stage, sex), environmental conditions, or the pathogen itself (including pathogenesis), or some combination of these factors (Voyles et al 2011). Recently, investigations have started to focus on the molecular basis of individual Bd isolates , Rosenblum et al 2010, and this line of research will be able to identify whether there are different strains of Bd, whether they vary regionally, and whether some are more virulent than others. It may be that strains existing in CT, or more broadly throughout New England, are less lethal than strains found in dieoff locations.…”
Section: Discussionmentioning
confidence: 99%
“…Not succumbing to lethal chytridiomycosis infections may be explained by the host's biology (including host defenses, life stage, sex), environmental conditions, or the pathogen itself (including pathogenesis), or some combination of these factors (Voyles et al 2011). Recently, investigations have started to focus on the molecular basis of individual Bd isolates , Rosenblum et al 2010, and this line of research will be able to identify whether there are different strains of Bd, whether they vary regionally, and whether some are more virulent than others. It may be that strains existing in CT, or more broadly throughout New England, are less lethal than strains found in dieoff locations.…”
Section: Discussionmentioning
confidence: 99%
“…The identification of mating and meiotic genes does not provide conclusive proof of actual sexual recombination because the functions of these genes may include additional pleiotropic roles that prevent their loss by genetic drift. However, a population genetic approach with the analysis of the pattern of genetic variability using high-resolution molecular markers allows inferences about the occurrence of recombination in the life history of the pathogen (Rosenblum et al, 2010).…”
Section: Introductionmentioning
confidence: 99%
“…Experimentally, there are interspecific differences in susceptibility to Bd and differences in virulence among Bd strains (Kilpatrick et al 2010, Rosenblum et al 2010, Gervasi et al 2013). Likewise, susceptibility to Rv differs greatly among species and among different developmental stages within a species (Hoverman et al 2010, Warne et al 2011.…”
Section: Introductionmentioning
confidence: 99%