A molecularly guided tour along the nephron

Bindels, René J. M.

doi:10.1007/s00424-009-0661-3

Cited by 2 publications

(3 citation statements)

References 19 publications

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Section: Discussionmentioning

confidence: 99%

“…For this reason, TAL is the decisive nephron segment to form concentrated or diluted urine [21][22][23] . In consequence of chloride reabsorption, a lumen-positive voltage is generated, allowing passive paracellular transport of Ca 2+ and Mg 2+ [11,21] . The protein kinase A, 20-hydroxyeicosatetraenoic acid and nitric oxide regulate the NKCC2 by inhibiting its action [24,25] .…”

Section: Discussionmentioning

confidence: 99%

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High Cholesterol Feeding May Induce Tubular Dysfunction Resulting in Hypomagnesemia

Favaro¹,

Oshiro-Monreal²,

Bragança³

et al. 2011

Kidney Blood Press Res

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Background/Aims: Hypomagnesemia may induce hypercholesterolemia, but the contrary has not been described yet. Thus, magnesium homeostasis was evaluated in rats fed a cholesterol-enriched diet for 8 days. This study has a relevant clinical application if hypomagnesemia, due to hypercholesterolemia, is confirmed in patients with long-term hypercholesterolemia. Methods: Both hypercholesterolemic (HC) and normocholesterolemic rats (NC) were divided into sets of experiments to measure hemodynamic parameters, physiological data, maximum capacity to dilute urine (C_H_₂_O), variations (Δ) in [Ca²⁺]_i and the expression of transporter proteins. Results: HC developed hypomagnesemia and showed high magnesuria in the absence of hemodynamic abnormalities. However, the urinary sodium excretion and C_H_₂_O in HC was similar to NC. On the other hand, the responses to angiotensin II by measuring Δ [Ca²⁺]_i were higher in the thick ascending limb of Henle’s loop (TAL) of HC than NC. Moreover, high expression of the cotransporter NKCC2 was found in renal outer medulla fractions of HC. Taken together, the hypothesis of impairment in TAL was excluded. Actually, the expression of the epithelial Mg²⁺ channel in renal cortical membrane fractions was reduced in HC. Conclusion: Impairment in distal convoluted tubule induced by hypercholesterolemia explains high magnesuria and hypomagnesemia observed in HC.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

High Cholesterol Feeding May Induce Tubular Dysfunction Resulting in Hypomagnesemia

Favaro¹,

Oshiro-Monreal²,

Bragança³

et al. 2011

Kidney Blood Press Res

View full text Add to dashboard Cite

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“…In addition, local/paracrine mechanisms contributes to this regulation (350). Several recent reviews specifically summarize different aspects of the epithelial transport in the CCD and CNT (46, 58, 149, 215, 334, 603, 610, 614). This article aims to overview the physiological function of the CCD and CNT based on variety of ion channels and transporters and their distinct properties and mechanisms of regulation.…”

Section: Introductionmentioning

confidence: 99%

Regulation of Transport in the Connecting Tubule and Cortical Collecting Duct

Staruschenko

2012

Comprehensive Physiology

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The central goal of this overview article is to summarize recent findings in renal epithelial transport, focusing chiefly on the connecting tubule (CNT) and the cortical collecting duct (CCD). Mammalian CCD and CNT are involved in fine tuning of electrolyte and fluid balance through reabsorption and secretion. Specific transporters and channels mediate vectorial movements of water and solutes in these segments. Although only a small percent of the glomerular filtrate reaches the CNT and CCD, these segments are critical for water and electrolyte homeostasis since several hormones, e.g. aldosterone and arginine vasopressin, exert their main effects in these nephron sites. Importantly, hormones regulate the function of the entire nephron and kidney by affecting channels and transporters in the CNT and CCD. Knowledge about the physiological and pathophysiological regulation of transport in the CNT and CCD and particular roles of specific channels/transporters has increased tremendously over the last two decades. Recent studies shed new light on several key questions concerning the regulation of renal transport. Precise distribution patterns of transport proteins in the CCD and CNT will be reviewed, and their physiological roles and mechanisms mediating ion transport in these segments will be also covered. Special emphasis will be given to pathophysiological conditions appearing as a result of abnormalities in renal transport in the CNT and CCD.

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A molecularly guided tour along the nephron

Cited by 2 publications

References 19 publications

High Cholesterol Feeding May Induce Tubular Dysfunction Resulting in Hypomagnesemia

High Cholesterol Feeding May Induce Tubular Dysfunction Resulting in Hypomagnesemia

Regulation of Transport in the Connecting Tubule and Cortical Collecting Duct

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