A monocyte-keratinocyte-derived co-culture assay accurately identifies efficacies of BET inhibitors as therapeutic candidates for psoriasiform dermatitis

Wu, Xuesong; Shi, Zhengang; Hsu, Daniel K.; Chong, J.; Huynh, Mindy; Mendoza, Lindsay; Yamada, Daisuke; Hwang, Sam T.

doi:10.1016/j.jdermsci.2020.08.005

Cited by 3 publications

(2 citation statements)

References 27 publications

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“…Additionally, it has been reported that OTX015 and ABBV075 can reduce the severity of imiquimod-induced psoriasis in mice. ABBV075 achieves the same pharmacodynamics at a dosage one-tenth of that required for OTX015 ( 161 ). Sato et al.…”

Section: Therapeutic Methods and Potential Therapeutic Methods Relate...mentioning

confidence: 99%

“…Additionally, it has been reported that OTX015 and ABBV075 can reduce the severity of imiquimodinduced psoriasis in mice. ABBV075 achieves the same pharmacodynamics at a dosage one-tenth of that required for OTX015 (161). Sato et al (162) designed and synthesized various pyrido-benzodiazepinone derivatives, among which one exhibited the most effective therapeutic effect in treating imiquimod-induced psoriasis mice.…”

Section: Bromodomain and Extraterminal Protein Inhibitormentioning

confidence: 99%

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Noval advance of histone modification in inflammatory skin diseases and related treatment methods

Zhang,

Chai,

Tai

et al. 2024

Front. Immunol.

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Inflammatory skin diseases are a group of diseases caused by the disruption of skin tissue due to immune system disorders. Histone modification plays a pivotal role in the pathogenesis and treatment of chronic inflammatory skin diseases, encompassing a wide range of conditions, including psoriasis, atopic dermatitis, lupus, systemic sclerosis, contact dermatitis, lichen planus, and alopecia areata. Analyzing histone modification as a significant epigenetic regulatory approach holds great promise for advancing our understanding and managing these complex disorders. Additionally, therapeutic interventions targeting histone modifications have emerged as promising strategies for effectively managing inflammatory skin disorders. This comprehensive review provides an overview of the diverse types of histone modification. We discuss the intricate association between histone modification and prevalent chronic inflammatory skin diseases. We also review current and potential therapeutic approaches that revolve around modulating histone modifications. Finally, we investigated the prospects of research on histone modifications in the context of chronic inflammatory skin diseases, paving the way for innovative therapeutic interventions and improved patient outcomes.

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Section: Therapeutic Methods and Potential Therapeutic Methods Relate...mentioning

confidence: 99%

Section: Bromodomain and Extraterminal Protein Inhibitormentioning

confidence: 99%

Noval advance of histone modification in inflammatory skin diseases and related treatment methods

Zhang,

Chai,

Tai

et al. 2024

Front. Immunol.

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A BET inhibitor, NHWD-870, can downregulate dendritic cells maturation via the IRF7-mediated signaling pathway to ameliorate imiquimod-induced psoriasis-like murine skin inflammation

Jin,

Dong,

Pei

et al. 2024

European Journal of Pharmacology

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In Vitro and Ex Vivo Models for Screening Topical Anti-Inflammatory Drugs

et al. 2023

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Skin inflammation occurs as an immune response to various stimuli such as ultraviolet light, irritants, or any type of skin barrier injury. Finding safe and effective drugs to combat skin inflammation remains a research challenge. Ethical and legal considerations in animal testing encourage the development of in vitro and ex vivo models for the detection of skin inflammation. This report presents an updated review of non-animal study models available for screening drugs with anti-inflammatory potential. It includes a description of the basic methods used to inhibit protein denaturation and red blood cell membrane stability. Three in vitro inhibition assay methods for enzymes relevant to the skin inflammatory process are then described. The development of cell culture models is described: relatively simple and easy-to-produce two-dimensional (2D) skin cell cultures that allow assessment of response to a given stimulus, three-dimensional (3D) cell cultures that better mimic human skin physiology by more accurately replicating mechanical and chemical signals, and vascularized 3D skin models with dynamic perfusion and microfluidic devices known as skin on a chip. Finally, ex vivo skin models are presented that could more accurately represent human skin in terms of structure, cell signaling mechanisms, and absorption effects. Although the current development of models without the use of animals is promising, improvements and refinements are needed to make the models more suitable as screening platforms for topical anti-inflammatory drugs.

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A monocyte-keratinocyte-derived co-culture assay accurately identifies efficacies of BET inhibitors as therapeutic candidates for psoriasiform dermatitis

Cited by 3 publications

References 27 publications

Noval advance of histone modification in inflammatory skin diseases and related treatment methods

Noval advance of histone modification in inflammatory skin diseases and related treatment methods

A BET inhibitor, NHWD-870, can downregulate dendritic cells maturation via the IRF7-mediated signaling pathway to ameliorate imiquimod-induced psoriasis-like murine skin inflammation

In Vitro and Ex Vivo Models for Screening Topical Anti-Inflammatory Drugs

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