2012
DOI: 10.1002/hep.25606
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A morphometric and immunohistochemical study to assess the benefit of a sustained virological response in hepatitis C virus patients with cirrhosis

Abstract: Although annular fibrosis is the hallmark of cirrhosis, other microscopic changes that affect liver function such as sinusoid capillarization or loss of metabolic zonation are common. A sustained virological response (SVR) may halt fibrosis deposition in hepatitis C virus (HCV)-infected patients, but its impact on the other cirrhosis-associated lesions is unknown. The aim of this study was to assess the impact of an SVR on cirrhosis-related histopathological features. Paired pre-and posttreatment liver biopsie… Show more

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Cited by 368 publications
(235 citation statements)
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“…D' Ambrosio et al 97 showed in a paired biopsy study in patients with HCVinduced liver cir rhosis who had been successfully treated for HCV infection that after 61 months from viral eradication (sustained virologic response), cirrhosis regression was observed in 61%, and the collagen content decreased in 89%. Critically, regression of cirrhosis can lead to a reduction in hard clinical endpoints (such as compli cations or death) 98 .…”
Section: Cirrhosis and Chronic Liver Injurymentioning
confidence: 99%
“…D' Ambrosio et al 97 showed in a paired biopsy study in patients with HCVinduced liver cir rhosis who had been successfully treated for HCV infection that after 61 months from viral eradication (sustained virologic response), cirrhosis regression was observed in 61%, and the collagen content decreased in 89%. Critically, regression of cirrhosis can lead to a reduction in hard clinical endpoints (such as compli cations or death) 98 .…”
Section: Cirrhosis and Chronic Liver Injurymentioning
confidence: 99%
“…There is now strong human evidence of fibrosis and cirrhosis reversibility in liver disease, most clearly in patients who have complete suppression of hepatitis B or cure of hepatitis C [9,10]. For hepatitis B, antiviral therapies have now evolved to the point where drug resistance is uncommon, and durable suppression of viral replication is the norm with current long-term use of antivirals, especially tenofovir.…”
Section: Evidence For Fibrosis Reversibility and Underlying Mechanismsmentioning
confidence: 99%
“…Although the SVR rate is known to be associated with disease severity [13,14], the virological response was shown to be associated with a decreased probability of developing esophageal varices, HCC and liver decompensation [15,16,17]. Moreover, some studies showed that SVR was also associated with a regression of fibrosis/cirrhosis [18,19,20]. …”
Section: Interferon-ribavirin Combination In Patients With Hcv-inducementioning
confidence: 99%