Due to the multi-factorial nature of the self-report of happiness, an enhancement program was designed that focused on mental style (subjective processes), and relationships, work, money, health, and leisure (objective life domains). An examination of interventions revealed mindfulness training (subjective factors) and goal setting (objective factors) as effective change modalities. To address this, the Mindfulness-based Quality of Life and Well-being Program (MQW) was developed and evaluated against the Mindfulness Attention Awareness Scale, Quality of Life Index, Personal Wellbeing Index–Adult, Positive and Negative Affect Scale, the Satisfaction with Life scale, and the newly developed Clinical Quality of Life Scale (CLINQOL). To explore training protocol effects, the program was delivered in a graduated (6 weekly sessions x 2 hours) and intensive (2 consecutive days x 6 hours) format. Using a randomized trial, participants were allocated across these conditions and a control. A total of 191 participants completed the study and were assessed at pre, post and follow up time points. Increases in mindfulness, quality of life, subjective well-being, and positive and negative affect (not life satisfaction), were greater in treated (combined formats) than control participants at post-test, and for mindfulness at follow up. Other than an increase in mindfulness for the 2 day condition at follow up, changes were similar in both intervention formats. Finally, to investigate what unique difference the MQW might have in comparison to teaching just mindfulness, the full version of the program was compared to an expanded section of the mindfulness component of the program. A total of 74 subjects began the program and filled out assessments across the three time periods. There was no difference between groups or an interaction between group and time. Overall, the findings provide preliminary evidence that a multi-dimensional training approach, using mindfulness and goal setting, may be a beneficial intervention model to enhance subjective and objective components in the perception of quality of life and well-being. However, further investigation into its added benefit to mindfulness alone is required.