A Mouse Model for Evaluating the Contribution of Fibrocytes and Myofibroblasts to Airway Remodeling in Allergic Asthma

Schmidt, Matthias; Mattoli, Sabrina

doi:10.1007/978-1-62703-496-8_19

Cited by 4 publications

(3 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These signals can be propagated through the dysregulation of the epithelial–mesenchymal trophic unit (EMTU), which is the bidirectional interaction between epithelium and mesenchyme involving the release of growth factors and cytokines, resulting in the amplification of inflammation and structural changes (remodeling) (43, 48). It is thought that the drivers of remodeling may be recruited CD34+ fibrocytes located at areas of collagen deposition and in BAL acting as myofibroblasts (49, 50), but it has also been proposed that they could stimulate the differentiation of resident mesenchymal cells (50). Epithelial cells can also transdifferentiate into fibroblasts/myofibroblasts by epithelial–mesenchymal transition (51), but this has not been proven in asthma (52).…”

Section: Airway Epithelium: Interactions Between Innate and Adaptive mentioning

confidence: 99%

Mechanisms Mediating Pediatric Severe Asthma and Potential Novel Therapies

Alonso

Saglani

2017

Front. Pediatr.

View full text Add to dashboard Cite

Although a rare disease, severe therapy-resistant asthma in children is a cause of significant morbidity and results in utilization of approximately 50% of health-care resources for asthma. Improving control for children with severe asthma is, therefore, an urgent unmet clinical need. As a group, children with severe asthma have severe and multiple allergies, steroid resistant airway eosinophilia, and significant structural changes of the airway wall (airway remodeling). Omalizumab is currently the only add-on therapy that is licensed for use in children with severe asthma. However, limitations of its use include ineligibility for approximately one-third of patients because of serum IgE levels outside the recommended range and lack of clinical efficacy in a further one-third. Pediatric severe asthma is thus markedly heterogeneous, but our current understanding of the different mechanisms underpinning various phenotypes is very limited. We know that there are distinctions between the factors that drive pediatric and adult disease since pediatric disease develops in the context of a maturing immune system and during lung growth and development. This review summarizes the current data that give insight into the pathophysiology of pediatric severe asthma and will highlight potential targets for novel therapies. It is apparent that in order to identify novel treatments for pediatric severe asthma, the challenge of undertaking mechanistic studies using age appropriate experimental models and airway samples from children needs to be accepted to allow a targeted approach of personalized medicine to be achieved.

show abstract

Section: Airway Epithelium: Interactions Between Innate and Adaptive mentioning

confidence: 99%

Mechanisms Mediating Pediatric Severe Asthma and Potential Novel Therapies

Alonso

Saglani

2017

Front. Pediatr.

View full text Add to dashboard Cite

show abstract

“…Thus, Fcs may contribute to the progression of fibrotic alterations every time there is a lack of asthma control and their effects persist as long as asthma control is not reachieved. Direct evidence of the contribution of Fcs to airway remodeling has been provided by tracking experiments in a mouse model of chronic allergic asthma with airway remodeling induced by repeated allergen exposures (Schmidt et al, 2003;Schmidt and Mattoli, 2013) and by assessing the effects of soluble factors present in the sputum of asthmatic patients on autologous circulating Fcs, including their migration, expression of the contractile protein α-SMA, and ability to release asthma-relevant EM molecules, in relation to the clinical characteristics and therapeutic responsiveness (Isgrò et al, 2013a). Moreover, in asthmatics with chronic bronchial obstruction, the numbers of circulating Fcs correlate with the previously recorded annual decline in lung function (Wang et al, 2008), suggesting that these cells may have contributed to generate irreversible alterations of the bronchial structure in such individuals.…”

Section: Contribution To Airway Remodeling In Persistent Asthmamentioning

confidence: 99%

Pathogenetic and prognostic roles of bloodborne fibrocytes in asthma

Mattoli

2015

J. Zhejiang Univ. Sci. B

Self Cite

View full text Add to dashboard Cite

Abstract:Bloodborne fibrocytes are cells mobilized from the bone marrow, which express surface antigens commonly ascribed to hematopoietic progenitors and have phenotypic and functional characteristics similar to those of immature mesenchymal cells. They exhibit predominant proinflammatory or profibrotic activities at tissue sites, depending on the host's response to environmental insults and on the characteristics of the cell infiltrate and cytokine milieu. In patients with allergic asthma, fibrocytes egress from the bone marrow and are recruited into the airways after every allergen exposure and during viral infections. Recruited fibrocytes amplify the inflammatory responses driven by T helper type 2 lymphokines and favor viral replication and further inflammation on respiratory virus infections. Persistently elevated blood fibrocyte counts and persisting airway fibrocytosis are present in patients with chronically undertreated or corticosteroid-insensitive asthma, and are linked to an enhanced risk of adverse outcomes because of the major involvement of fibrocytes in the development of structural abnormalities that lead to chronic airflow obstruction in these patients. Consequently, blood fibrocyte count is an emerging biomarker of asthma control and disease progression and its clinical applicability as a new outcome measure deserves further evaluation in large clinical trials.

show abstract

“…For instance, T cell subsets include CD4⁺, CD8⁺ T cells [ 1 ], Th2, Th17 [ 2 ], Th9 [ 3 ], and so on. Except for immune-relevant cells, structural cells of the airways, such as epithelial cells [ 4 ], smooth muscle cells [ 5 ], and bronchial myofibroblasts [ 6 ], are also an important focus of research. In recent years, cell therapy has attracted the attention of researchers to treat asthma and its complications.…”

Section: Introductionmentioning

confidence: 99%

The Cell Research Trends of Asthma: A Stem Frequency Analysis of the Literature

Tang

Shang

Xiao

et al. 2018

Journal of Healthcare Engineering

View full text Add to dashboard Cite

Objective This study summarized asthma literature indexed in the Medical Literature Analysis and Retrieval System Online (MEDLINE) and explored the history and present trends of asthma cell research by stem frequency ranking to forecast the prospect of future work. Methods Literature was obtained from MEDLINE for the past 30 years and divided into three groups by decade as the retrieval time. The frequency of stemmed words in each group was calculated using Python with Apache Spark and the Natural Language Tool Kit for ranking. The unique stems or shared stems of 3 decades were summarized. Results A total of 1331, 4393, and 7215 records were retrieved from 3 decades chronologically, and the stem ranking of the top 50 were listed by frequency. The number of stems shared with 3 decades was 26 and with the first and last 2 decades was 5 and 13. Conclusions The number of cell research studies of asthma has increased rapidly, and scholars have paid more attentions on experimental research, especially on mechanistic research. Eosinophils, mast cells, and T cells are the hot spots of immunocyte research, while epithelia and smooth muscle cells are the hot spots of structural cell research. The research trend is closely linked with the development of experimental technology, including animal models. Early studies featured basic research, but immunity research has dominated in recent decades. The distinct definition of asthma phenotypes associated with genetic characteristics, immunity research, and the introduction of new cells will be the hot spots in future work.

show abstract

A Mouse Model for Evaluating the Contribution of Fibrocytes and Myofibroblasts to Airway Remodeling in Allergic Asthma

Cited by 4 publications

References 39 publications

Mechanisms Mediating Pediatric Severe Asthma and Potential Novel Therapies

Mechanisms Mediating Pediatric Severe Asthma and Potential Novel Therapies

Pathogenetic and prognostic roles of bloodborne fibrocytes in asthma

The Cell Research Trends of Asthma: A Stem Frequency Analysis of the Literature

Contact Info

Product

Resources

About