A MRI spatial mapping technique for microvascular permeability and tissue blood volume based on macromolecular contrast agent distribution

Demšar, Franci; Roberts, Timothy P.L.; Schwickert, Heidi C.; Shames, David M.; Dijke, Cornelis F. van; Mann, Jeffry S.; Saeed, Maythem; Brasch, Robert C.

doi:10.1002/mrm.1910370216

Cited by 74 publications

(64 citation statements)

References 36 publications

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“…Our findings suggest that ICG, although not developed as a cancer targeting dye, could find applications in DOT mammography. Additionally, it should be pointed out that the study of macromolecular contrast agent kinetics enables the independent estimation of vascularization and permeability (47)(48)(49). Such differentiation has been demonstrated by MRI using albuminbound-Gd and is examined by the MR community as a surrogate to increasing specificity (47,50,51).…”

Section: Discussionmentioning

confidence: 99%

Concurrent MRI and diffuse optical tomography of breast after indocyanine green enhancement

Ntziachristos

Yodh

Schnall

et al. 2000

Proc. Natl. Acad. Sci. U.S.A.

750

525

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We present quantitative optical images of human breast in vivo. The images were obtained by using near-infrared diffuse optical tomography (DOT) after the administration of indocyanine green (ICG) for contrast enhancement. The optical examination was performed concurrently with a magnetic resonance imaging (MRI) exam on patients scheduled for excisional biopsy or surgery so that accurate image coregistration and histopathological information of the suspicious lesions was available. The ICG-enhanced optical images coregistered accurately with Gadolinium-enhanced magnetic resonance images validating the ability of DOT to image breast tissue. In contrast to simple transillumination, we found that DOT provides for localization and quantification of exogenous tissue chromophore concentrations. Additionally our use of ICG, an albumin bound absorbing dye in plasma, demonstrates the potential to differentiate disease based on the quantified enhancement of suspicious lesions.optical properties ͉ contrast agents ͉ MRI coregistration

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Section: Discussionmentioning

confidence: 99%

Concurrent MRI and diffuse optical tomography of breast after indocyanine green enhancement

Ntziachristos

Yodh

Schnall

et al. 2000

Proc. Natl. Acad. Sci. U.S.A.

750

525

View full text Add to dashboard Cite

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“…The two-compartment model was used to generate tissue concentration curves using a set of values for K trans , v e , and v p , and a fixed set of plasma parameters (Eq. [12]). 2.…”

Section: Parameter Estimation Using Linear and Nonlinear Methodsmentioning

confidence: 99%

“…The dynamics, therefore, are relatively slow compared to an extravascular agent, which makes the delivery permeability-rather than flow-limited. Intravascular agents have been used extensively to study the vascular volume and vessel permeability in tumors (5,8,9), but have had limited use in the context of skeletal (10) or myocardial (11,12) muscle. One advantage of macromolecular agents is that they are sensitive to changes in capillary permeability and thus may have application in the identification of reperfusion injury (13) or the recognition of angiogenic neovasculature (14).…”

mentioning

confidence: 99%

Measurement of kinetic parameters in skeletal muscle by magnetic resonance imaging with an intravascular agent

Faranesh

Kraitchman

McVeigh

2006

Magnetic Resonance in Med

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The purpose of this work was to investigate the use of an intravascular contrast agent to determine perfusion kinetics in skeletal muscle. A two-compartment kinetic model was used to represent the flux of contrast agent between the intravascular space and extravascular extracellular space (EES). The relationship between the image signal-to-noise ratio (SNR) and errors in estimating permeability surface area product (K trans ), interstitial volume (v e ), and plasma volume (v p ) for linear and nonlinear curve-fitting methods was estimated from Monte Carlo simulations. Similar results were obtained for both methods. For an image SNR of 60, the estimated errors in these parameters were 10%, 22%, and 17%, respectively. In vivo experiments were conducted in rabbits to examine physiological differences between these parameters in the soleus (SOL) and tibialis anterior (TA) muscles in the hind limb. Values for K trans were significantly higher in the SOL (3.2 ؎ 0.9 vs. 2.0 ؎ 0.5 ؋ 10 -3 min -1 ), as were values for v p (3.4 ؎ 0.8 vs. 2.1 ؎ 0.7%). Differences in v e for the two muscles (8.7 ؎ 2.2 vs. 8.5 ؎ 1.6%) were not found to be significant. These results demonstrate that relevant physiological metrics can be calculated in skeletal muscle using MRI with an intravascular contrast agent. Magn Reson Med 55:1114

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“…When administered i.v., this agent does not diffuse through endothelium, unless there is a pathological change (Demsar et al, 1997;Beravs et al, 2000). The size of the agent is approximately 30 kDa, facilitating its complete renal elimination.…”

Section: Dynamic Contrast-enhanced Mrimentioning

confidence: 99%

Reduced blood flow and oxygenation in SA-1 tumours after electrochemotherapy with cisplatin

et al. 2002

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Electrochemotherapy is an antitumour treatment that utilises locally delivered electric pulses to increase cytotoxicity of chemotherapeutic drugs. Besides increased drug delivery, application of electric pulses affects tumour blood flow. The aim of this study was to determine tumour blood flow modifying effects of electrochemotherapy with cisplatin, its effects on tumour oxygenation and to determine their relation to antitumour effectiveness. Electrochemotherapy of SA-1 subcutaneous tumours was performed by application of electric pulses to the tumours, following administration of cisplatin. Tumour blood flow modifying effects of electrochemotherapy were determined by measurement of tumour perfusion using the Patent blue staining technique, determination of tumour blood volume, and microvascular permeability using contrast enhanced magnetic resonance imaging, and tumour oxygenation using electron paramagnetic resonance oximetry. Antitumour effectiveness was determined by tumour growth delay and the extent of tumour necrosis and apoptosis. Tumour treatment by electrochemotherapy induced 9.4 days tumour growth delay. Tumour blood flow was reduced instantaneously and persisted for several days. This reduction in tumour blood flow was reflected in reduced tumour oxygenation. The maximal reduction in partial oxygen pressure (pO 2 ) levels was observed at 2 h after the treatment, with steady recovery to the pretreatment level within 48 h. The reduced tumour blood flow and oxygenation correlated well with the extent of tumour necrosis and tumour cells apoptosis induced by electrochemotherapy with cisplatin. Therefore, the data indicate that antitumour effectiveness of electrochemotherapy is not only due to increased cytotoxicity of cisplatin due to electroporation of tumour cells, but also due to anti-vascular effect of electrochemotherapy, which resulted in reduced tumour blood flow and oxygenation.

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A MRI spatial mapping technique for microvascular permeability and tissue blood volume based on macromolecular contrast agent distribution

Cited by 74 publications

References 36 publications

Concurrent MRI and diffuse optical tomography of breast after indocyanine green enhancement

Concurrent MRI and diffuse optical tomography of breast after indocyanine green enhancement

Measurement of kinetic parameters in skeletal muscle by magnetic resonance imaging with an intravascular agent

Reduced blood flow and oxygenation in SA-1 tumours after electrochemotherapy with cisplatin

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