A mu-opioid feedback model of human social behavior

Meier, Isabell M.; Honk, Jack van; Bos, Peter A.; Terburg, David

doi:10.1016/j.neubiorev.2020.12.013

Cited by 22 publications

(13 citation statements)

References 113 publications

(200 reference statements)

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“…This was most prominently observed in the medial and prefrontal cortex, which is well known for its role in for social inference and decision making [53], and structural imaging studies has shown that frontocortical volumes are associated with the brevity of human social networks [54,55]. The present studies raise the possibility that MORmediated responses to others' distress in the frontal cortex could be a putative mechanism leading to helping those who are in distress and concomitant strengthening of social bonds, highlighting the MOR-dependent modulation of social motivation [56].…”

Section: Mors and Distress Signal Processingsupporting

confidence: 51%

Mu-opioid receptor system modulates responses to vocal bonding and distress signals in humans

Sun

Lukkarinen

Karlsson

et al. 2021

Preprint

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Laughter is a contagious prosocial signal that conveys bonding motivation; adult crying conversely communicates desire for social proximity by signalling distress. Endogenous mu-opioid receptors (MORs) modulate sociability in humans and non-human primates. In this combined PET-fMRI study (n=17) we tested whether central MOR tone is associated with regional brain responses to social signals of laughter and crying sounds. MOR availability was measured with positron emission tomography using high-affinity agonist radioligand [11C]carfentanil. Haemodynamic responses to social laughter and crying sounds were measured using functional magnetic resonance imaging (fMRI). Social laughter evoked activation in the auditory cortex, insula, cingulate cortex, amygdala, primary and secondary somatosensory cortex, primary and secondary motor cortex; crying sounds led to more restricted activation in auditory cortex and nearby areas. MOR availability was negatively correlated with the haemodynamic responses to social laughter in primary and secondary somatosensory cortex, primary and secondary motor cortex, posterior insula, posterior cingulate cortex, precuneus, cuneus, temporal gyri, and lingual gyrus. For crying-evoked activations, MOR availability was negatively correlated with medial and lateral prefrontal haemodynamic responses. Altogether our findings highlight the role of MOR system in modulating acute brain responses to both positive and negative social signals.

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Section: Mors and Distress Signal Processingsupporting

confidence: 51%

Mu-opioid receptor system modulates responses to vocal bonding and distress signals in humans

Sun

Lukkarinen

Karlsson

et al. 2021

Preprint

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“…Continuous exposure to exogenous opioid medications alters responsivity to social rewards. 11 Tapering these exogenous opioids may unsettle this system again. Normal responsivity to social and other nondrug rewards may not resume for months.…”

mentioning

confidence: 99%

Long-term opioid therapy unsettles us both coming and going

Sullivan

2021

Pain

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“…A recent review proposes “[…] based upon recent findings of opioid modulation of human social learning, bonding and empathy in relation to affiliative and protective tendencies. Fundamental to the model is that the mu-opioid system reinforces socially affiliative or protective behavior in response to positive and negative social experiences with long-term consequences for social behavior and health” ( 72 ). Lacking of pro-social touch, caring and protective behavior in childhood is a key feature of CM and may result in a long-term modification of the endogenous opioid system.…”

Section: Discussionmentioning

confidence: 99%

A History of Childhood Maltreatment Has Substance- and Sex-Specific Effects on Craving During Treatment for Substance Use Disorders

et al. 2022

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RationaleChildhood maltreatment (CM) leads to detrimental mental health outcomes, such as substance use disorders (SUD). This study examined prevalence and severity of all five types of CM with respect to specific substances and sex in treatment-seeking individuals with SUD. The influences of type of CM and symptoms of depressiveness, anxiety, and perceived stress on substance craving at admission as well as craving reduction during SUD treatment were examined.MethodsN = 546 patients in treatment for SUD and N = 109 individuals in opioid maintenance treatment filled out questionnaires regarding CM (Childhood Trauma Questionnaire) and psychopathologies. Substance craving was assessed throughout treatment using the Mannheim Craving Scale. Group differences in CM, type of substance and sex were examined. General linear models were applied to examine influences on substance craving.ResultsHigher prevalence and severity of all five subtypes of CM were observed in individuals with SUD compared to the general population. Women were more severely affected by emotional and sexual abuse than men. Patients with cannabis use disorder reported more severe experiences of emotional abuse compared to all other substances. Craving at admission to treatment was influenced by emotional abuse, however, symptoms of depressiveness, anxiety, and perceived stress contributed to craving at admission or craving reduction during treatment.ConclusionCM relates to SUD and should be incorporated in prevention and treatment of SUD. Underlying mechanisms of the association might relate to impairments in processing and regulation of stress, emotions, and interpersonal relations following a history of CM.

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A mu-opioid feedback model of human social behavior

Cited by 22 publications

References 113 publications

Mu-opioid receptor system modulates responses to vocal bonding and distress signals in humans

Mu-opioid receptor system modulates responses to vocal bonding and distress signals in humans

Long-term opioid therapy unsettles us both coming and going

A History of Childhood Maltreatment Has Substance- and Sex-Specific Effects on Craving During Treatment for Substance Use Disorders

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