A mucinous adenocarcinoma of the lip with elevated serum carcinoembryonic antigen levels: a case report

Aoki, Takayuki; Kondo, Yusuke; Karakida, Kazunari; Naito, Hiroyuki; Kajiwara, Hiroshi; Ota, Yoshihide

doi:10.1007/s10006-019-00818-6

Cited by 5 publications

(6 citation statements)

References 19 publications

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“…In the present case the more commonly known conditions that cause an elevated CEA were excluded: ovarian cancer, pancreatic cancer, gastric cancer and thyroid cancer [3]. In addition, a literature search revealed several case reports presenting rare entities that cause elevated CEA levels, such as head and neck cancer, mucinous adenocarcinoma of the lip, hypothyroidism, a apocrine hidrocystoma and lithium use, but none of these were helpful for our patient [7][8][9][10][11][12]. With elevated CEA levels as high as in our patient, distant or local recurrence of the rectal cancer was on the top of our differential diagnosis list, followed by a second primary tumour.…”

Section: Discussionmentioning

confidence: 87%

A Remarkable Case of Elevated Carcinoembryonic Antigen after Surgical Treatment of Rectal Cancer: A Search for its Mysterious Cause

Beets¹,

Bastelaar²,

Bosmans³

2020

SCR

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Introduction: Measuring carcinoembryonic antigen (CEA) serum levels is frequently used as a biomarker for recurrent disease in follow-up after treatment of colorectal cancer. However, it is also elevated to a significant degree in a number of other malignant and non-malignant conditions. In this case, we present a patient with ongoing elevated CEA levels without a clear cause. Case Presentation: A 57-year-old female patient with adenocarcinoma of the rectum underwent neoadjuvant chemoradiation and a laparoscopic low anterior resection. During follow-up she presented without any clear symptoms but with an ongoing elevation of serum CEA levels, for which she underwent four sequential PET-CT scans within one year without any sign of malignancy. Other causes of elevated CEA levels were investigated and excluded by additional blood tests and imaging studies. Available literature was extensively reviewed but revealed no further possible explanations for the high CEA serum level. Conclusion: The manifestation of an exponential rise of CEA levels following the treatment of colorectal cancer in the absence of abnormalities is a rare presentation and remains a mystery. The cause of the elevated CEA is yet to be elucidated

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Section: Discussionmentioning

confidence: 87%

A Remarkable Case of Elevated Carcinoembryonic Antigen after Surgical Treatment of Rectal Cancer: A Search for its Mysterious Cause

Beets¹,

Bastelaar²,

Bosmans³

2020

SCR

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“…Thus, CEA is recognised as a beneficial indicator in determining the metastatic potential of malignant cells [29] . This is supported by another case study, where T. Aoki et al ., found that there was a significant elevation of serum CEA in patients who suffered from Mucinous adenocarcinoma (MAC) [30] . Besides, the CEA expression was also increased as the human lung carcinoma cells when irradiation was used as an indicator under a fixed time frame of 72 h [31] …”

Section: Cea the Typical Serum Tumour Biomarkermentioning

confidence: 99%

“…[29] This is supported by another case study, where T. Aoki et al, found that there was a significant elevation of serum CEA in patients who suffered from Mucinous adenocarcinoma (MAC). [30] Besides, the CEA expression was also increased as the human lung carcinoma cells when irradiation was used as an indicator under a fixed time frame of 72 h. [31] Secondly, CEA is a regulating intercellular adhesion in various forms of molecules. A previous study by A. Calinescu et al has shown that the alternative splicing mechanism of CEArelated cell-adhesion molecule 1 (CEACAM1) held an important role in inflammation.…”

Section: The Role Of Ceamentioning

confidence: 99%

Recent Advances in Nanomaterial‐based Optical Biosensors as Potential Point‐of‐Care Testing (PoCT) Probes in Carcinoembryonic Antigen Detection

Lee

Pandian

et al. 2022

Chemistry An Asian Journal

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For the past decades, several cancer biomarkers have been exploited for rapid and accurate prognosis or diagnosis purposes. In this review, the optical biosensor is targeted for carcinoembryonic antigen (CEA) detection. The CEA level is a prominent parameter currently used in clinical cases for the prognosis of cancer-related diseases. Many nanomaterial-based biosensors are invented as alternatives for the commonly used enzyme-linked immunosorbent assays (ELISA) immunoassay method in CEA detection as the traditional approach. But they possess certain drawbacks such as tedious procedure, high technical demand, and costly. Nevertheless, the effort appears to be wasted as none of them are being actualised. Generally, the sensor function was carried out by converting bio-signals generated upon the interface of the receptor into light signals. These sensors were popular due to specific advantages such as sensitivity, being free from chemical and electromagnetic interferences, wide dynamic range, and being easy to be monitored. The features of PoC diagnostics are discussed and associated to the various applications of colorimetric-based and chemiluminescent-based biosensors. The roles of nanomaterials in each application were also summarised by comparing the modification, incubation period, lowest detection limit (LOD) and linear range of detection amount. The challenges and future perspectives were highlighted as well at the end of the review.

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“…Tumors with colloid architecture, defined by malignant cells floating in lakes of extracellular mucin, were recognized as a standalone entity under the name mucinous adenocarcinoma in the 2005 World Health Organization (WHO) Classification of Head and Neck Tumours. [1][2][3][4][5][6][7][8][9][10][11][12][13] Invasive tumors composed of papillary mucinous epithelium, alternately described as papillary cystadenocarcinomas or mucus-producing adenopapillary carcinomas, also were included as a significant component of the cystadenocarcinoma category in the 2005 WHO. [13][14][15][16][17][18][19] Signet ring carcinomas composed of discohesive cells with intracellular mucin vacuoles have also rarely been described.…”

mentioning

confidence: 99%

“…Historically, these tumors have largely been characterized in the literature in single case reports and small series, which divided them into several categories based on distinctive histologic patterns. Tumors with colloid architecture, defined by malignant cells floating in lakes of extracellular mucin, were recognized as a standalone entity under the name mucinous adenocarcinoma in the 2005 World Health Organization (WHO) Classification of Head and Neck Tumours 1–13. Invasive tumors composed of papillary mucinous epithelium, alternately described as papillary cystadenocarcinomas or mucus-producing adenopapillary carcinomas, also were included as a significant component of the cystadenocarcinoma category in the 2005 WHO 13–19.…”

mentioning

confidence: 99%

Salivary Mucinous Adenocarcinoma Is a Histologically Diverse Single Entity With Recurrent AKT1 E17K Mutations

Rooper

Argyris

Thompson

et al. 2021

American Journal of Surgical Pathology

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Mucin-producing salivary adenocarcinomas were historically divided into separate colloid carcinoma, papillary cystadenocarcinoma, and signet ring cell carcinoma diagnoses based on histologic pattern, but have recently been grouped together in the adenocarcinoma not otherwise specified category. It is currently unclear if these tumors represent 1 or more distinct entities and how they are related to well-circumscribed papillary mucinous lesions with recurrent AKT1 E17K mutations that were recently described as salivary intraductal papillary mucinous neoplasm. Here, we sought to evaluate the clinicopathologic and molecular features of salivary mucinous adenocarcinomas to clarify their classification. We identified 17 invasive mucin-producing salivary adenocarcinomas, 10 with a single histologic pattern, and 7 with mixed patterns. While most tumors demonstrated papillary growth (n=15), it was frequently intermixed with colloid (n=6) and signet ring (n=3) architecture with obvious transitions between patterns. All were cytokeratin 7 positive (100%) and cytokeratin 20 negative (0%). Next-generation sequencing performed on a subset demonstrated recurrent AKT1 E17K mutations in 8 cases (100%) and TP53 alterations in 7 cases (88%). Of 12 cases with clinical follow-up (median: 17 mo), 4 developed cervical lymph node metastases, all of which had colloid or signet ring components. Overall, overlapping histologic and immunohistochemical features coupled with recurrent AKT1 E17K mutations across patterns suggests that mucin-producing salivary adenocarcinomas represent a histologically diverse single entity that is closely related to tumors described as salivary intraductal papillary mucinous neoplasm. We propose a unified mucinous adenocarcinoma category subdivided into papillary, colloid, signet ring, and mixed subtypes to facilitate better recognition and classification of these tumors.

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A mucinous adenocarcinoma of the lip with elevated serum carcinoembryonic antigen levels: a case report

Cited by 5 publications

References 19 publications

A Remarkable Case of Elevated Carcinoembryonic Antigen after Surgical Treatment of Rectal Cancer: A Search for its Mysterious Cause

A Remarkable Case of Elevated Carcinoembryonic Antigen after Surgical Treatment of Rectal Cancer: A Search for its Mysterious Cause

Recent Advances in Nanomaterial‐based Optical Biosensors as Potential Point‐of‐Care Testing (PoCT) Probes in Carcinoembryonic Antigen Detection

Salivary Mucinous Adenocarcinoma Is a Histologically Diverse Single Entity With Recurrent AKT1 E17K Mutations

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