Predictive analytics has become an essential area of research in health informatics. The availability of multi-source and multi-modal data in healthcare has made the disease prediction, diagnosis, and medication process more effective and reliable. However, the analysis and decision making have become challenging task, particularly when data is in multiple formats and from different sources. In this study, different frameworks have been proposed to handle multi-nature data at different levels for predictive analytics. Dimensionality reduction techniques have been applied to extract relevant features to enhance the analysis. To improve the performance of predictive analytics at different fusion levels, the potential benefits of multi-modal data have been discussed. Moreover, notable improvement in prediction accuracy has been observed through experimental evaluation of the proposed frameworks. Furthermore, the issues which have been found during dimension reduction and fusion approaches have also been highlighted.