A Multi‐Center Study Comparing Dual Acid‐Etched and Machined‐Surfaced Implants in Various Bone Qualities

Khang, Wahn; Feldman, Sylvan; Hawley, Charles E.; Gunsolley, John C.

doi:10.1902/jop.2001.72.10.1384

Cited by 154 publications

(117 citation statements)

References 18 publications

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“…The in vitro observations are correlated with in vivo assessments of pull-out strength. There is greater bone-to-implant contact when implants with rough microtopographies are used and greater torque is required to remove the implants after bone healing [2][3][4].…”

Section: Introductionmentioning

confidence: 99%

Beta-1 integrins mediate substrate dependent effects of 1α,25(OH)2D3 on osteoblasts

Schwartz

Bell

Wang

et al. 2007

The Journal of Steroid Biochemistry and Molecular Biology

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Surface microroughness increases osteoblast differentiation and enhances responses of osteoblasts to 1,25-dihydroxyvitamin D 3 [1α,25(OH) 2 D 3 ]. β 1 integrin expression is increased in osteoblasts grown on Ti substrates with rough microarchitecture, and it is regulated by 1α,25(OH) 2 D 3 in a surface-dependent manner, suggesting that it has a role in mediating osteoblast response. Here, we silenced β 1 expression in MG63 human osteoblast-like cells using small interfering RNA (siRNA) and examined the responses of the β 1 -silenced osteoblasts to surface microtopography and 1α,25 (OH) 2 D 3 . MG63 cells were also treated with two different monoclonal antibodies to human β 1 to block ligand binding. β 1 -silenced MG63 cells grown on a tissue culture plastic had reduced alkaline phosphatase activity and levels of osteocalcin, transforming growth factor β1, prostaglandin E 2 , and osteoprotegerin in comparison with control cells. Moreover, β 1 -silencing inhibited the effects of surface roughness on these parameters and partially inhibited effects of 1α,25(OH) 2 D 3 . Anti β 1 antibody AIIB2 had no significant effect on cell number and osteocalcin, but decreased alkaline phosphatase; MAB2253Z decreased cell number and alkaline phosphatase and increased osteocalcin in a dose-dependent manner. Effects of 1α,25(OH) 2 D 3 on cell number and alkaline phosphatase were reduced and effects on osteocalcin were increased. These findings indicate that β 1 plays a major and complex role in osteoblastic differentiation modulated by either surface microarchitecture or 1α,25 (OH) 2 D 3 . The results also show that β 1 mediates, in part, the synergistic effects of surface roughness and 1α,25(OH) 2 D 3 .

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Section: Introductionmentioning

confidence: 99%

Beta-1 integrins mediate substrate dependent effects of 1α,25(OH)2D3 on osteoblasts

Schwartz

Bell

Wang

et al. 2007

The Journal of Steroid Biochemistry and Molecular Biology

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“…Many of these are commercially available although some may only have had a short history of commercial life. 11,12 The implant neck design is one of these areas of development. Micro-textured and the macro-textured surfaces were explored.…”

Section: Introductionmentioning

confidence: 99%

Marginal tissue response to different implant neck design

Bae

Chung

Cha

et al. 2008

J Korean Acad Prosthodont

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STATEMENT OF PROBLEM:Loss of the marginal bone to the first thread have been accepted but continuous effort have been made to reduce this bone loss by varying implant design and surface texture. PURPOSE: This animal study has examined the histomorphometric variations between implants with micro-thread, micro-grooved and turned surfaced neck designs. MATERIAL AND METHODS: Four mongrel dogs have been used the premolars removed and left to heal for three months. One of each implant systems with turned neck, micro-thread and micro-grooved were placed according to the manufacturers'protocol and left submerged for 8 and 12 weeks. These were then harvested for histological examination. RESULTS: The histologically all samples were successfully ossointegrated and active bone remodelling adjacent to implants. With the micro-grooved implants 0.40 mm and 0.26 mm of the marginal bone level changes were observed at 8 and 12 weeks respectively. The micro-threaded implants had changes of 0.79 mm and 0.56 mm at 8 and 12 weeks respectably. The turned neck designed implants had marginal bone level changes of 1.61 mm and 1.63 mm in 8 and 12 weeks specimens. A complex soft tissue arrangement could be observed against micro-threaded and micro-grooved implant surfaces. CONCLUSION: Within the limitations of this study, it could be concluded that implants with micro-grooved had the least and the turned neck designed implants had the most changes in the marginal bone level. The textured implant surfaces affect soft tissue responses.

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“…Anodized coatings were evaluated with SEM, TEM, XRD, XPS, and laser microscope. Anodized specimens were implanted in rats' tibia for 14 d, and then extracted.When anodized in concentrated (2 M) H 3 PO 4 aqueous solutions under spark discharge, crystallized anatase transformed to amorphous anatase by containing a large amount of PO [3][4] in crystal lattice of TiO 2 . The amorphous anatase coatings had better osteoconductivity than the crystallized anatase coatings.…”

mentioning

confidence: 99%

“…The amorphous anatase coatings had better osteoconductivity than the crystallized anatase coatings. It is not exactly clear what was the intrinsic factor for the high osteoconductivity, but the crystallinity of anatase and/or PO [3][4] in the film is considered to be responsible for the difference in bone forming ability of TiO 2 films. …”

mentioning

confidence: 99%

Formation of Amorphous TiO2 Film on Ti Using Anodizing in Concentrated H3PO4 Aqueous Solution and Its Osteoconductivity

Yamamoto¹,

Iida²,

Kuroda³

et al. 2013

J. Japan Inst. Metals

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Anodizing of Ti specimens were performed in concentrated H 3 PO 4 aqueous solutions with a purpose to incorporate a large amount of phosphate ion into anodized coatings, and their osteoconductivity was evaluated in in vivo test. Ti specimens were anodized in 0.1～11 M H 3 PO 4 aqueous solutions up to 200 V at a rate of 0.1 V s -1 . Anodized coatings were evaluated with SEM, TEM, XRD, XPS, and laser microscope. Anodized specimens were implanted in rats' tibia for 14 d, and then extracted.When anodized in concentrated (2 M) H 3 PO 4 aqueous solutions under spark discharge, crystallized anatase transformed to amorphous anatase by containing a large amount of PO [3][4] in crystal lattice of TiO 2 . The amorphous anatase coatings had better osteoconductivity than the crystallized anatase coatings. It is not exactly clear what was the intrinsic factor for the high osteoconductivity, but the crystallinity of anatase and/or PO [3][4] in the film is considered to be responsible for the difference in bone forming ability of TiO 2 films.

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A Multi‐Center Study Comparing Dual Acid‐Etched and Machined‐Surfaced Implants in Various Bone Qualities

Abstract: The difference in success rates is most likely attributed to the acid-etched surface characteristics. The greatest performance difference is observed in the conditions of poor quality or soft bone where the 3-year post-loading CSR are 96.8% (dual acid-etched) and 84.8% (machined-surfaced).

Cited by 154 publications

References 18 publications

Beta-1 integrins mediate substrate dependent effects of 1α,25(OH)2D3 on osteoblasts

Beta-1 integrins mediate substrate dependent effects of 1α,25(OH)2D3 on osteoblasts

Marginal tissue response to different implant neck design

Formation of Amorphous TiO2 Film on Ti Using Anodizing in Concentrated H3PO4 Aqueous Solution and Its Osteoconductivity

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