A multi-channel collagen conduit with aligned Schwann cells and endothelial cells for enhanced neuronal regeneration in spinal cord injury

Lee, Hye Yeong; Moon, Seo Hyun; Kang, Donggu; Choi, Eunjeong; Yang, Gi Hoon; Kim, Keung Nyun; Won, Joo Yun; Yi, Seong

doi:10.1039/d3bm01152f

Cited by 5 publications

(2 citation statements)

References 83 publications

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“…Other Hydrogels [180,181,253,254], PLGA [255] and PLA [256] Collagen [181,257], CS [258], silk [259,260], decellularised ECM [227], modified gelatine [261] R-GSIK [262], electrospun nanofiber nets [263] and gene scaffolds [264] Gold nanoparticle nerve guidance conduits [265] and collagen conduits [266] Graphene oxide [267], IGF-1 delivery via nanofibrous dural substitutes [197] and ROS scavenger materials [170,171] Table 2. Cont.…”

Section: Nerve Guidancementioning

confidence: 99%

Neurotrauma—From Injury to Repair: Clinical Perspectives, Cellular Mechanisms and Promoting Regeneration of the Injured Brain and Spinal Cord

Stevens,

Belli,

Ahmed

2024

Biomedicines

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Traumatic injury to the brain and spinal cord (neurotrauma) is a common event across populations and often causes profound and irreversible disability. Pathophysiological responses to trauma exacerbate the damage of an index injury, propagating the loss of function that the central nervous system (CNS) cannot repair after the initial event is resolved. The way in which function is lost after injury is the consequence of a complex array of mechanisms that continue in the chronic phase post-injury to prevent effective neural repair. This review summarises the events after traumatic brain injury (TBI) and spinal cord injury (SCI), comprising a description of current clinical management strategies, a summary of known cellular and molecular mechanisms of secondary damage and their role in the prevention of repair. A discussion of current and emerging approaches to promote neuroregeneration after CNS injury is presented. The barriers to promoting repair after neurotrauma are across pathways and cell types and occur on a molecular and system level. This presents a challenge to traditional molecular pharmacological approaches to targeting single molecular pathways. It is suggested that novel approaches targeting multiple mechanisms or using combinatorial therapies may yield the sought-after recovery for future patients.

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Section: Nerve Guidancementioning

confidence: 99%

Neurotrauma—From Injury to Repair: Clinical Perspectives, Cellular Mechanisms and Promoting Regeneration of the Injured Brain and Spinal Cord

Stevens,

Belli,

Ahmed

2024

Biomedicines

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“…This disruption can result in demyelination, which in turn can compromise axonal conduction and further deteriorate neuronal function [ 20 , 25 ]. Moreover, neurons undergo Wallerian degeneration, characterized by axonal swelling and cytoskeletal rearrangements, leading to the breakdown and degeneration of axons and their innervation structures [ 26 , 27 ].…”

Section: Pathophysiology Of Scimentioning

confidence: 99%

The roles of neural stem cells in myelin regeneration and repair therapy after spinal cord injury

Li,

Luo,

2024

Stem Cell Res Ther

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Spinal cord injury (SCI) is a complex tissue injury that results in a wide range of physical deficits, including permanent or progressive disabilities of sensory, motor and autonomic functions. To date, limitations in current clinical treatment options can leave SCI patients with lifelong disabilities. There is an urgent need to develop new therapies for reconstructing the damaged spinal cord neuron-glia network and restoring connectivity with the supraspinal pathways. Neural stem cells (NSCs) possess the ability to self-renew and differentiate into neurons and neuroglia, including oligodendrocytes, which are cells responsible for the formation and maintenance of the myelin sheath and the regeneration of demyelinated axons. For these properties, NSCs are considered to be a promising cell source for rebuilding damaged neural circuits and promoting myelin regeneration. Over the past decade, transplantation of NSCs has been extensively tested in a variety of preclinical models of SCI. This review aims to highlight the pathophysiology of SCI and promote the understanding of the role of NSCs in SCI repair therapy and the current advances in pathological mechanism, pre-clinical studies, as well as clinical trials of SCI via NSC transplantation therapeutic strategy. Understanding and mastering these frontier updates will pave the way for establishing novel therapeutic strategies to improve the quality of recovery from SCI.

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Embracing the future: The application of regenerative biomaterials in the spinal disorders

Xu,

Fang,

et al. 2025

Biomedical Technology

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A multi-channel collagen conduit with aligned Schwann cells and endothelial cells for enhanced neuronal regeneration in spinal cord injury

Abstract: Traumatic spinal cord injury (SCI) leads to Wallerian degeneration and the accompanying disruption of vasculature leads to ischemia, which damages motor and sensory function. Therefore, understanding the biological environment during...

Cited by 5 publications

References 83 publications

Neurotrauma—From Injury to Repair: Clinical Perspectives, Cellular Mechanisms and Promoting Regeneration of the Injured Brain and Spinal Cord

Neurotrauma—From Injury to Repair: Clinical Perspectives, Cellular Mechanisms and Promoting Regeneration of the Injured Brain and Spinal Cord

The roles of neural stem cells in myelin regeneration and repair therapy after spinal cord injury

Embracing the future: The application of regenerative biomaterials in the spinal disorders

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