A multi-cohort consortium for GEnder-Sensitive Analyses of mental health trajectories and implications for prevention (GESA) in the general population in Germany

Burghardt, Juliane; Tibubos, Ana Nanette; Otten, Daniëlle; Brähler, Elmar; Binder, Harald; Grabe, Hans J.; Kruse, Johannes; Ladwig, Karl Heinz; Schomerus, Georg; Wild, Philipp S.; Beutel, Manfred E.

doi:10.1136/bmjopen-2019-034220

Cited by 11 publications

(9 citation statements)

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“…The GESA consortium (GEnder-Sensitive Analyses of mental health trajectories and implications for prevention: A multi-cohort consortium) [ 24 ] included three major, ongoing, longitudinal cohorts in middle, southern and northeast Germany: the Gutenberg Health Study (GHS) [ 26 ], the Cooperative Health Research in the Augsburg Region (KORA) [ 27 , 28 ] and the Study of Health in Pomerania (SHIP) [ 29 ]. These regions differ in their socioeconomic and regional characteristics [ 24 ]. Middle and southern Germany are economically stronger than northeast Germany (e.g.…”

Section: Methodsmentioning

confidence: 99%

“…Religiosity is higher in southern Germany and lowest in northeast Germany [ 30 ]. Based on the assessments of specific psychosocial variables, different waves of these cohorts were selected for the GESA consortium [ 24 ]. For this study GHS F1, KORA F4 and SHIP3 including data from the years 2006–2016 were selected, 304 (1.5%) (GHS 278, KORA 16 and SHIP 10) respondents with missings on all PHQ-9 items were excluded, which lead to a total sample of N = 19,504.…”

Section: Methodsmentioning

confidence: 99%

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Bidimensional structure and measurement equivalence of the Patient Health Questionnaire-9: sex-sensitive assessment of depressive symptoms in three representative German cohort studies

et al. 2021

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Background The Patient Health Questionnaire-9 (PHQ-9) has been proposed as a reliable and valid screening instrument for depressive symptoms with one latent factor. However, studies explicitly testing alternative model structures found support for a two-dimensional structure reflecting a somatic and a cognitive-affective dimension. We investigated the bidimensional structure of the PHQ-9, with a somatic (sleeping problems, fatigability, appetitive problems, and psychomotor retardation) and a cognitive-affective dimension (lack of interest, depressed mood, negative feelings about self, concentration problems, and suicidal ideation), and tested for sex- and regional-differences. Methods We have included data from the GEnder-Sensitive Analyses of mental health trajectories and implications for prevention: A multi-cohort consortium (GESA). Privacy-preserving analyses to provide information on the overall population and cohort-specific information and analyses of variance to compare depressive, somatic and cognitive-affective symptoms between sexes and cohorts were executed in DataSHIELD. In order to determine the dimensionality and measurement invariance of the PHQ-9 we tested three models (1 factor, 2 correlated factors, and bifactor) via confirmatory analyses and performed multi-group confirmatory factor analysis. Results Differences between sex and cohorts exist for PHQ-9 and for both of its dimensions. Women reported depressive symptoms in general as well as somatic and cognitive-affective symptoms more frequently. For all tested models an acceptable to excellent fit was found, consistently indicating a better model fit for the two-factor and bifactor model. Scalar measurement invariance was established between women and men, the three cohorts, and their interaction. Conclusions The two facets of depression should be taken into account when using PHQ-9, while data also render support to a general factor. Somatic and cognitive-affective symptoms assessed by the PHQ-9 can be considered equivalent across women and men and between different German populations from different regions.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Bidimensional structure and measurement equivalence of the Patient Health Questionnaire-9: sex-sensitive assessment of depressive symptoms in three representative German cohort studies

et al. 2021

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“…The GESA consortium (GEnder-Sensitive Analyses of mental health trajectories and implications for prevention: A multi-cohort consortium) included high-quality data on mental and somatic symptoms in over 40,000 participants from multiple longitudinal cohorts in Germany ( 16 ): the Gutenberg Health Study (GHS) conducted in southeast Germany ( 17 ), the Cooperative Health Research in the Augsburg Region (KORA) conducted in southern Germany ( 18 , 19 ), and the Study of Health in Pomerania (SHIP) conducted in northeast Germany ( 20 ). The combined samples originate from different German regions; their different socioeconomic characteristics will inform gender-sensitive analyses ( 16 ).…”

Section: Methodsmentioning

confidence: 99%

“…The different measures, waves, and age structures of the cohorts require substantial harmonization and complicate interpretations ( 16 ). DataSHIELD (Data Aggregation through Anonymous Summary-statistics from Harmonized Individual LevEL Databases) was used to conduct a pooled analysis of multiple cohort study data, which enables describing and analyzing large-scale and complex interactions in epidemiological studies.…”

Section: Methodsmentioning

confidence: 99%

“…In the current study, we aim to shed light on the mediating role of depression in the link between childhood emotional abuse and incident type 2 diabetes among German community-dwelling participants from a multi-cohort study ( 16 ). We hypothesize that the predictive value of childhood emotional abuse on the increased risk of type 2 diabetes in adulthood can largely be attributed to detrimental effects of depression ( 5 ).…”

Section: Introductionmentioning

confidence: 99%

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Depression Mediates the Association Between Childhood Emotional Abuse and the Onset of Type 2 Diabetes: Findings From German Multi-Cohort Prospective Studies

et al. 2022

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BackgroundThe dysregulation of glucose homeostasis via mental health stress is increasingly acknowledged, whereby depression independently increases the risk of the onset of type 2 diabetes by up to 60%. Contributing mental health factors starting in early life have further been considered, indicating that exposure to childhood emotional abuse is associated with both depression and an increased onset of type 2 diabetes in adulthood. However, the potential role of depression within the emotional abuse and type 2 diabetes link remains unknown.MethodsData were derived from community-dwelling participants in southern and northeastern Germany who participated in the longitudinal KORA-F4 and SHIP-3 studies. Multivariable logistic regression analyses adjusted for lifestyle, somatic, and psychological risk factors were used to investigate the association between childhood emotional abuse, assessed retrospectively by the Childhood Trauma Screener, and newly diagnosed type 2 diabetes cases, which were confirmed using a standard oral glucose tolerance test. The mediating role of depressive symptoms between childhood emotional abuse and type 2 diabetes was assessed by the Patient Health Questionnaire-9 and calculated by using the Sobel test for mediation.ResultsA total of 2,973 (53.2% women, 46.8% men) participants with a mean age of 49.7 were included in the analyses, of whom 5.9% (7.1% women, 4.5% men) reported emotional abuse in childhood. Participants exposed to childhood emotional abuse had a 1.70 (1.12–2.56; p = 0.02) times higher odds of depression in the fully adjusted model than unexposed participants. During the 6.5-year follow-up period, 104 (3.5%) participants developed type 2 diabetes. Participants who were exposed to childhood emotional abuse had a 2.56 (1.31–4.98, p = 0.005) times higher odds of developing type 2 diabetes than unexposed participants. This association was significantly mediated by the increased odds of depression in participants with childhood emotional abuse (Sobel Test, 1.84, p = 0.06; Goodman Test, 1.91, p = 0.05).ConclusionThe current results indicate that the increased likelihood of type 2 diabetes onset in participants who were exposed to childhood emotional abuse is significantly attributed to increased depression in adulthood.

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Gender-Differential Association Between Loneliness and Alcohol Consumption: a Pooled Analysis of 17,808 Individuals in the Multi-Cohort GESA Consortium

Johar

Atasoy

Beutel

et al. 2023

Int J Ment Health Addiction

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Loneliness is an established risk factor for impaired health. However, the evidence of whether increased alcohol consumption is a coping mechanism to alleviate loneliness for both genders remains sparse. The cross-sectional study included 8898 men and 8910 women (mean age of 56.2 ± 11.5 years) from three population-based cohort studies in Germany (KORA-FF4, GHS, and SHIP. Daily alcohol consumption (g/day) was measured, and risky drinking was identified using gender-specific thresholds (40 g/day for men and 20 g/day for women). Loneliness was assessed by asking if the participants feel lonely. Multivariable regression analyses were employed to examine the association between alcohol use outcomes and loneliness with adjustments for confounders. Women reported feeling lonely more frequently than men (14.8% vs 10.4%). In men, loneliness was positively associated with levels of alcohol consumption (ß = 1.75, SE = 0.76, p = 0.04) and risky drinking (OR = 1.33, 95% CI = 1.07–1.66, p = 0.02) and was even more profound in men with lower educational levels. In women, loneliness was associated with reduced odds of risky consumption (OR = 0.76, 95% CI = 0.60–0.96, p = 0.02) but not with alcohol consumption levels. The findings indicate gender-differential associations of loneliness with increased levels and risky alcohol consumption in men but with decreased risky consumption in women.

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A multi-cohort consortium for GEnder-Sensitive Analyses of mental health trajectories and implications for prevention (GESA) in the general population in Germany

Cited by 11 publications

References 44 publications

Bidimensional structure and measurement equivalence of the Patient Health Questionnaire-9: sex-sensitive assessment of depressive symptoms in three representative German cohort studies

Bidimensional structure and measurement equivalence of the Patient Health Questionnaire-9: sex-sensitive assessment of depressive symptoms in three representative German cohort studies

Depression Mediates the Association Between Childhood Emotional Abuse and the Onset of Type 2 Diabetes: Findings From German Multi-Cohort Prospective Studies

Gender-Differential Association Between Loneliness and Alcohol Consumption: a Pooled Analysis of 17,808 Individuals in the Multi-Cohort GESA Consortium

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