A Multi-Crystal Positron Camera

Burnham, C.A.; Brownell, G.L.

doi:10.1109/tns.1972.4326726

Cited by 90 publications

(32 citation statements)

References 2 publications

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“…and Brownell, as reported by Sweet (1951). The first successful posi tron scanner was described by Brownell and Sweet in 1953 (also Burham and Brownell in 1972). In 1959, Anger described his version of a positron im aging device using the scintillation camera (Anger and Rosenthal, 1959).…”

Section: Historical Development Of Pctmentioning

confidence: 99%

Study of Cerebral Function with Positron Computed Tomography

Phelps¹,

Mazziotta

Huang³

1982

J Cereb Blood Flow Metab

365

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Section: Historical Development Of Pctmentioning

confidence: 99%

Study of Cerebral Function with Positron Computed Tomography

Phelps¹,

Mazziotta

Huang³

1982

J Cereb Blood Flow Metab

365

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“…This development in positron tracers mirrored the progress in positron imaging. In the 1970s, Massachusetts General Hospital developed, what was then, the most advanced coincidence positron camera system, with a spatial resolution of approximately 1 cm [12] . This was followed by developments predominantly in single photon emission computed tomography (SPECT) with work done by Kuhl, Budinger and Gullberg, and in 1974, there were reports of the development of a dedicated single-plane positron emission transaxial tomograph, which was the precursor to the current PET systems.…”

Section: The Development Of Positron Emission Tomographymentioning

confidence: 99%

“…Overexpression of these receptors allows for the targeted imaging and possible therapy of such tumors, with ongoing evaluation on the use of 68 Ga and other radioisotope-labeled bombesin analogues. Synthetic bombesin analogues can be categorized into two forms: type-A analogues are truncated peptides with only a portion retained, usually the BN (7)(8)(9)(10)(11)(12)(13)(14) at the C terminus, and Type-B analogues, which are full-length synthetics. Type-A analogues are usually more accepted, as they are more stable in vivo and yet maintain acceptable receptor binding capability [77] .…”

Section: Bombesin Was First Described In 1970 By Erspamer Et Almentioning

confidence: 99%

Exploring new frontiers in molecular imaging: Emergence of⁶⁸Ga PET/CT

Tan

Goh²

2010

WJR

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Since US Food and Drug Administration approval of 18-fluorodeoxyglucose as a positron tracer, and the development of hybrid positron emission tomography/ computed tomography machines, there has been a great increase in clinical application and progress in the field of nuclear molecular imaging. However, not underestimating the value of 18 F, there are known limitations in the use of this cyclotron-produced positron tracer. We hence turn our focus to an emerging positron tracer, 68 Ga, and examine the advantages, current clinical uses and potential future applications of this radioisotope. THE DEVELOPMENT OF POSITRON EMISSION TOMOGRAPHYPositron emission tomography (PET) imaging is essentially a story of a technique in wait of a technology. Since the discovery of positron emission in 1933 by Thibaud and Joliot et al, and the subsequent report of the coincident nature of emissions by Klemperer and Beringer, it has in effect taken close to half a century for the full realization of PET imaging in mainstream medical practice [1] . The history of PET development is a fascinating look into the technological advances in molecular medicine, and the account of Terry Jones provides fascinating reading [1] . The first use of positron tracers was likely performed in the 1940s using 11 CO in animal models [2] , with its first possible use in humans performed in the 1950s at the Hammersmith Hospital in London, United Kingdom using 15 O2 in studies of lung ventilation [3] . This was followed by increasing use of positron tracers in the physiological assessment of lung function, which resulted in the installation of the world's first hospital-based cyclotron in 1955. Subsequently, development shifted into myocardial perfusion [4] , cerebral perfusion [5][6][7] , and of course, glucose metabolism [8][9][10][11] . This development in positron tracers mirrored the progress in positron imaging. In the 1970s, Massachusetts General Hospital developed, what was then, the most advanced coincidence positron camera system, with a spatial resolution of approximately 1 cm [12] . This was followed by developments predominantly in single photon emission computed tomography (SPECT) with work done by Kuhl, Budinger and Gullberg, and in 1974, there were reports of the development of a dedicated single-plane positron emission transaxial tomograph, which was the precursor to the current PET systems.These developments explain the slow implementation of PET into clinical practice, as synchronous developments in both tracer and detector technology were reWorld Journal of Radiology W J R

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“…Na década de 1970, novos avanços em computação e, principalmente, no desenvolvimento e na implementação de méto-dos de reconstrução permitiram a realização de tomografias por emissão de fótons únicos (single photon emission computed tomography, SPECT -o que foi feito por David E. Kuhl e sua equipe na Universidade da Pensilvânia (10)-e de PET, por Gordon L. Brownell e colaboradores no Hospital Geral de Massachusetts (11,12) e por Michael E. Phelps e colegas na Universidade da Califórnia em Los Angeles (13,14). Vale destacar a contribuição de David Chesler (15) ao propor e reconstruir cortes tomográ-ficos de emissão e transmissão pelo método da retroprojeção, em 1971.…”

Section: Um Pouco De Históriaunclassified

A tomografia por emissão de pósitrons: uma nova modalidade na medicina nuclear brasileira

Robilotta¹

2006

Rev Panam Salud Publica

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A medicina nuclear é uma especialidade médica que utiliza compostos (ou moléculas) marcados com radionuclídeos, os radiofármacos, para fins de diagnóstico e terapia. Esses compostos seguem caminhos funcionais ou metabólicos específicos dentro dos pacientes, o que confere a essa modalidade diagnóstica uma característica de natureza bioló-gica que as outras modalidades não possuem. A detecção externa da radiação emitida pelo radiofár-maco permite diagnosticar precocemente muitas doenças, enquanto que as alterações anatômicas, muitas vezes, não se manifestam senão em estágios relativamente avançados, como no caso de diversos tipos de câncer.Outra característica importante dos exames realizados com radiofármacos é a sua alta sensibilidade-isto é, é possível obter informações biológi-cas com concentrações de radiofármacos em níveis de nano ou picomolares. Além disso, a marcação de diferentes moléculas com um único radionuclídeo permite avaliações e estudos de um mesmo órgão ou sistema em seus aspectos tanto macroscópicos quanto moleculares. Tais estudos podem ser realizados através de imagens obtidas in vivo ou através de ensaios laboratoriais. Atualmente, a maior parte dos estudos radionuclídicos clínicos é de imagens, em especial as tomográficas.Neste artigo, serão relatados, inicialmente, alguns fatos históricos sobre o desenvolvimento da medicina nuclear, seguidos de uma apresentação dos aspectos físicos da tomografia por emissão de pósitrons (positron emission tomography, PET); finalmente, será abordada a situação desta modalidade no Brasil.Palavras-chave: compostos radiofarmacêuticos, diagnóstico por imagem, PET, imagem funcional, Brasil.

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A Multi-Crystal Positron Camera

Cited by 90 publications

References 2 publications

Study of Cerebral Function with Positron Computed Tomography

Study of Cerebral Function with Positron Computed Tomography

Exploring new frontiers in molecular imaging: Emergence of⁶⁸Ga PET/CT

A tomografia por emissão de pósitrons: uma nova modalidade na medicina nuclear brasileira

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A Multi-Crystal Positron Camera

Cited by 90 publications

References 2 publications

Study of Cerebral Function with Positron Computed Tomography

Study of Cerebral Function with Positron Computed Tomography

Exploring new frontiers in molecular imaging: Emergence of68Ga PET/CT

A tomografia por emissão de pósitrons: uma nova modalidade na medicina nuclear brasileira

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Product

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Exploring new frontiers in molecular imaging: Emergence of⁶⁸Ga PET/CT