| INTRODUC TI ONProgress in basic and clinical research is strongly dependent upon asking important research questions, attempting to answer those questions with robust methods, and then communicating the findings. Persuading colleagues that scientific results are objectively obtained and valid involves a willingness to report accurate, robust, and transparent descriptions of the methods, procedures, and outcomes, which will allow for the independent replication, or reproducibility, of those findings (see Box 1 for definitions).Publishers have the responsibility of providing a platform for the exchange of scientific information, while at the same time it is Abstract Progress in basic and clinical research is slowed when researchers fail to provide a complete and accurate report of how a study was designed, executed, and the results analyzed. Publishing rigorous scientific research involves a full description of the methods, materials, procedures, and outcomes. Investigators may fail to provide a complete description of how their study was designed and executed because they may not know how to accurately report the information or the mechanisms are not in place to facilitate transparent reporting. Here, we provide an overview of how authors can write manuscripts in a transparent and thorough manner. We introduce a set of reporting criteria that can be used for publishing, including recommendations on reporting the experimental design and statistical approaches. We also discuss how to accurately visualize the results and provide recommendations for peer reviewers to enhance rigor and transparency. Incorporating transparency practices into research manuscripts will significantly improve the reproducibility of the results by independent laboratories.
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