A multi-etiology model of systemic degeneration in schizophrenia

L-Theanine Relieves Positive, Activation, and Anxiety Symptoms in Patients With Schizophrenia and Schizoaffective Disorder

“…There are other modern theories of schizophrenia that can provide an explanation to this contradiction. [57][58][59] The specific mechanisms by which L-theanine exerts its neuroprotective action are just beginning to be studied and clarified. L-Theanine acts antagonistically against the stimulatory effects of caffeine on the nervous system.…”

Genetic variants of the inflammatory C‐reactive protein and schizophrenia in Armenian population: a pilot study

“…Several possible mechanisms underlie this disease pathology such as altered DNA methylation (Feng & Fan, 2009), apoptotic engulfment pathway (Chen et al. , 2009), prefrontal‐limbic and autoimmune dysregulation, abnormal glutamatergic transmission (Rădulescu, 2009), hyper‐ and hypofunction of dopaminergic system in brain different regions and microglial hypothesis (reviewed in Monji et al. , 2009).…”

Integrative Etiopathogenetic Models of Psychotic Disorders: Methods, Evidence and Concepts

“…The theoretical mechanisms for such multiple pathophysiologic factors interacting on the functions of a certain brain region have been described in an example using the prefrontal-limbic system in schizophrenia by Radulescu. 31 The central idea of Howes and Kapur 32 is that multiple risk factors for psychoses like frontotemporal dysfunctions, genetic factors, prenatal infections, stress, and drugs may lead to a common final pathway of presynaptic hyperdopaminergic dysfunction. Gene-environment interactions could be integrated in this model via epigenetic regulation of genes of dopamine metabolism.…”