2020
DOI: 10.1002/aic.16295
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A multi‐faceted approach to analyzing glucose heat‐degradants and evaluating impact to a CHO cell culture process

Abstract: Glucose solutions are commonly heated before use in medical and biotech applications to maintain cleanliness, however the resulting degradants can be toxic. This study examines two approaches to evaluating the heat degradants resulting from holding a 40% glucose solution at 55°C for 5 weeks: first, chemical changes to the solution were identified and quantified via analytical testing, and second the toxicity of the heat‐degraded 40% glucose solution was evaluated empirically by using it as a feed stock for a f… Show more

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