A multi-generational study on low-dose BPA exposure in Wistar rats: Effects on maternal behavior, flavor intake and development

Boudalia, Sofiane; Berges, Raymond; Chabanet, Claire; Folia, Mireille; Decocq, Laurence; Pasquis, Bruno; Abdennebi-Najar, Latifa; Canivenc-Lavier, Marie-Chantal

doi:10.1016/j.ntt.2013.11.002

Cited by 54 publications

(42 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Further, perinatal exposure to BPA alters the maternal behavior of F1 dams and induces body weight increases in the F2 generation only (Boudalia et al, 2014). Changes in maternal behavior have also been shown in female CD-1 mice exposed to BPA as fetuses or as adult dams in late pregnancy (Palanza et al, 2002).…”

Section: Discussionmentioning

confidence: 95%

Milk lipid composition is modified by perinatal exposure to bisphenol A

Altamirano

Muñoz-de-Toro

Luque

et al. 2015

Molecular and Cellular Endocrinology

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 95%

Milk lipid composition is modified by perinatal exposure to bisphenol A

Altamirano

Muñoz-de-Toro

Luque

et al. 2015

Molecular and Cellular Endocrinology

View full text Add to dashboard Cite

“…Mansilha et al (2013) exposed Daphnia magna to BPA (from 1000 to 3000 mg/L) over five generations, and the further magnification of the adverse effects on mortality and fecundity were observed. Boudalia et al (2014) conducted a multigenerational study on low-dose BPA exposure (5 mg/kg BW/ day) in Wistar rats. The results showed that both gestational (F 0 ) and lifelong (F 1 ) exposures to a human-relevant dose of BPA could impose multigenerational effects on both development and behavior, and might lead to permanent changes in biological systems which maintained homeostasis.…”

Section: Introductionmentioning

confidence: 99%

Ecotoxicity of bisphenol A to Caenorhabditis elegans by multigenerational exposure and variations of stress response in vivo across generations

Zhou

Yang

et al. 2016

Environmental Pollution

View full text Add to dashboard Cite

“…BPA induces deleterious physiological effects in a number of tissues (19,24,25), including structural changes in brain regions that are associated with changes in behavior (26). A small number of studies suggest that BPA can alter maternal behaviors in rodents (27)(28)(29)(30)(31)(32). In 1 study, female mice exposed to 10 mg BPA/kg/d during pregnancy days 14 to 18 spent less time nursing and less time on the nest compared with unexposed females (28).…”

mentioning

confidence: 98%

Bisphenol S (BPS) alters maternal behavior and brain in mice exposed during pregnancy/lactation and their daughters

Catanese

Vandenberg

2016

Endocrinology

View full text Add to dashboard Cite

Estrogenic endocrine disrupting chemicals have been shown to disrupt maternal behavior in rodents. We investigated the effects of an emerging xenoestrogen, bisphenol S (BPS), on maternal behavior and brain in CD-1 mice exposed during pregnancy and lactation (F0 generation) and in female offspring exposed during gestation and perinatal development (F1 generation). We observed different effects in F0 and F1 dams for a number of components of maternal behavior, including time on the nest, time spent on nest building, latency to retrieve pups, and latency to retrieve the entire litter. We also characterized expression of estrogen receptor a in the medial preoptic area (MPOA) and quantified tyrosine hydroxylase immunoreactive cells in the ventral tegmental area, 2 brain regions critical for maternal care. BPS-treated females in the F0 generation had a statistically significant increase in estrogen receptor a expression in the caudal subregion of the central MPOA in a dose-dependent manner. In contrast, there were no statistically significant effects of BPS on the MPOA in F1 dams or the ventral tegmental area in either generation. This work demonstrates that BPS affects maternal behavior and brain with outcomes depending on generation, dose, and postpartum period. Many studies examining effects of endocrine disrupting chemicals view the mother as a means by which offspring can be exposed during critical periods of development. Here, we demonstrate that pregnancy and lactation are vulnerable periods for the mother. We also show that developmental BPS exposure alters maternal behavior later in adulthood. Both findings have potential public health implications. (Endocrinology 158: 516-530, 2017)

show abstract

A multi-generational study on low-dose BPA exposure in Wistar rats: Effects on maternal behavior, flavor intake and development

Cited by 54 publications

References 59 publications

Milk lipid composition is modified by perinatal exposure to bisphenol A

Milk lipid composition is modified by perinatal exposure to bisphenol A

Ecotoxicity of bisphenol A to Caenorhabditis elegans by multigenerational exposure and variations of stress response in vivo across generations

Bisphenol S (BPS) alters maternal behavior and brain in mice exposed during pregnancy/lactation and their daughters

Contact Info

Product

Resources

About