In-memory Computing (IMC) is the new trend for enabling high-performance computation and fast data processing. It is currently being used for large enterprises, e-commerce shops who need real-time interactions, low latency responses and instant results. Given the enhancement of the IMC, we apply this new paradigm to the Virtual Desktop Environment (VDE), and look into the performance differences in comparison with traditional VDE. The end results shows positive feedback, but there are trade-offs we need to concern for the In-memory Virtual Desktop Environment.