A multi-hit therapeutic nanoplatform for hepatocellular carcinoma: Dual stimuli-responsive drug release, dual-modal imaging, and in situ oxygen supply to enhance synergistic therapy

Chen, Taiying; Tam, Nga Lei; Mao, Yu; Sun, Chengjun; Wang, Zekang; Hou, Ying; Xia, Wuzheng; Yu, Jia; Wu, Linwei

doi:10.1016/j.mtbio.2022.100338

Cited by 3 publications

(2 citation statements)

References 67 publications

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“…For example, a size-switching strategy has been proposed: larger nanoparticles transform into smaller ones upon entering the tumor [ [163] , [164] , [165] , [166] ], effectively increasing the depth of drug penetration [ 167 , 168 ]. Additionally the design of nanomedicine with charge-reversal properties has been reported [ [169] , [170] , [171] , [172] ]. Maintaining neutral or weakly negative surface charges in the circulation and switching to positive charges within tumors can improve tumor penetration while reducing toxicity and uptake by the reticuloendothelial system.…”

Section: Strategies To Improve Drug Penetration Into Solid Tumorsmentioning

confidence: 99%

Enhancing drug penetration in solid tumors via nanomedicine: Evaluation models, strategies and perspectives

Shen,

Pan,

Gong

et al. 2024

Bioactive Materials

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Section: Strategies To Improve Drug Penetration Into Solid Tumorsmentioning

confidence: 99%

Enhancing drug penetration in solid tumors via nanomedicine: Evaluation models, strategies and perspectives

Shen,

Pan,

Gong

et al. 2024

Bioactive Materials

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“…Photothermal therapy (PTT), which is based on transduction of the absorbed light energy to generate heat, presents a particular external stimulation approach for killing cancer cells. Near infrared (NIR) laser-mediated thermal therapy has been investigated to induce release of drug molecules [ 12 , 13 , 14 ]. To date, indocyanine green (ICG) ( Scheme 1 B) remains the only FDA-approved NIR-activated agent for clinical applications ranging from ophthalmic angiography, cardiocirculatory measurements, assessment of hepatic function, and blood flow evaluation.…”

Section: Introductionmentioning

confidence: 99%

Erythrocyte-Derived Nanoparticles with Folate Functionalization for Near Infrared Pulsed Laser-Mediated Photo-Chemotherapy of Tumors

Mac

Vankayala²,

Lee

et al. 2022

IJMS

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Despite its common side effects and varying degrees of therapeutic success, chemotherapy remains the gold standard method for treatment of cancer. Towards developing a new therapeutic approach, we have engineered nanoparticles derived from erythrocytes that contain indocyanine green as a photo-activated agent that enables near infrared photothermal heating, and doxorubicin hydrochloride (DOX) as a chemotherapeutic drug. We hypothesize that milliseconds pulsed laser irradiation results in rapid heating and photo-triggered release of DOX, providing a dual photo-chemo therapeutic mechanism for tumor destruction. Additionally, the surface of the nanoparticles is functionalized with folate to target the folate receptor-α on tumor cells to further enhance the therapeutic efficacy. Using non-contract infrared radiometry and absorption spectroscopy, we have characterized the photothermal response and photostability of the nanoparticles to pulsed laser irradiation. Our in vitro studies show that these nanoparticles can mediate photo-chemo killing of SKOV3 ovarian cancer cells when activated by pulsed laser irradiation. We further demonstrate that this dual photo-chemo therapeutic approach is effective in reducing the volume of tumor implants in mice and elicits an apoptotic response. This treatment modality presents a promising approach in destruction of small tumor nodules.

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Emerging nanomedicine strategies for hepatocellular carcinoma therapy

Guo,

Zhang,

Cai

et al. 2024

iMetaOmics

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Hepatocellular carcinoma (HCC) is a prevalent malignant tumor with a range of risk factors, including viral infections, alcoholic liver disease, exposure to fungal toxins, obesity, and type 2 diabetes. Despite advancements in early detection and treatment, HCC continues to exhibit a high rate of recurrence. Patients in advanced stages have a poor prognosis, and the survival rate after cancer metastasis is notably low. Consequently, there exists an urgent necessity for novel treatment strategies. Nanomedicine possesses superior attributes, such as targeted administration and responsive drug release within the tumor microenvironment. These systems demonstrate potential in HCC treatment by facilitating the transportation of diverse therapeutic drugs. This comprehensive review aims to delve into the application of nanoparticle drug delivery systems in the management of liver tumors, with particular emphasis on formulation, targeted strategies specific to liver tumors, and various methods of drug release. By offering insights into the utilization of nanoparticle drug delivery systems in the realm of liver tumor treatment, this review endeavors to assist readers in exploring their vast potential.

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A multi-hit therapeutic nanoplatform for hepatocellular carcinoma: Dual stimuli-responsive drug release, dual-modal imaging, and in situ oxygen supply to enhance synergistic therapy

Cited by 3 publications

References 67 publications

Enhancing drug penetration in solid tumors via nanomedicine: Evaluation models, strategies and perspectives

Enhancing drug penetration in solid tumors via nanomedicine: Evaluation models, strategies and perspectives

Erythrocyte-Derived Nanoparticles with Folate Functionalization for Near Infrared Pulsed Laser-Mediated Photo-Chemotherapy of Tumors

Emerging nanomedicine strategies for hepatocellular carcinoma therapy

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