2015
DOI: 10.1016/j.eururo.2014.10.021
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A Multi-institutional Prospective Trial in the USA Confirms that the 4Kscore Accurately Identifies Men with High-grade Prostate Cancer

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Cited by 341 publications
(242 citation statements)
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“…Aggressive tumors were identified as those having any Gleason 4 or 5 patterns in the prostatic biopsy, using the 2005 consensus Gleason definition. 7,8 Quantitative variables were expressed as median and range, and qualitative variables as rates. The efficacy of %fPSA, PSAd and PHI was compared through ROC curves analysis and thresholds to detect 90%, 95% of all tumors and 95% and 100% of aggressive tumors were generated.…”
Section: Methodsmentioning
confidence: 99%
“…Aggressive tumors were identified as those having any Gleason 4 or 5 patterns in the prostatic biopsy, using the 2005 consensus Gleason definition. 7,8 Quantitative variables were expressed as median and range, and qualitative variables as rates. The efficacy of %fPSA, PSAd and PHI was compared through ROC curves analysis and thresholds to detect 90%, 95% of all tumors and 95% and 100% of aggressive tumors were generated.…”
Section: Methodsmentioning
confidence: 99%
“…The test has been validated in several subsequent studies evaluating previously screened men, unscreened men, and men with a prior negative biopsy 67,68,[70][71][72][73] (area under the curve [AUC] of 0.71-0.82). The 4Kscore was also validated in a large, prospective study of 1012 men from 26 different centres in the U.S. 74 The 4Kscore demonstrated a better discrimination in predicting Gleason ≥7 cancer compared to the modified Prostate Cancer Prevention Trial Risk Calculator 2.0 model (AUC 0.82 vs. 0.74; p<0.0001).…”
Section: Four-kallikrein Panel (4kscore ® )mentioning
confidence: 99%
“…Also, the authors underline that the detection of high-grade tumors was delayed in only 0.63%-0.70% of patients compared with biopsying all patients with PSA ≥ 3 μg/L, using, respectively, the four-kallikrein panel or the fourkallikrein panel+DRE. More recently, a multicenter and prospective evaluation of the four-kallikrein panel in the detection of high-grade PCa has been published [71]. The study included 1012 men scheduled for prostate biopsy, obtaining an AUC of 0.82.…”
Section: Four-kallikrein Panelmentioning
confidence: 99%