The strong demand for sustainable energy supplies had escalated the discovery, and intensive research into cleaner energy sources, as well as efficient energy management practices. In the context of the circular economy, the efforts target not only the optimisation of resource utilisation at various stages, but the products’ eco-design is also emphasized to extend their life spans. Based on the concept of comprehensive circular integration, this review discusses the roles of Process Integration approaches, renewable energy sources utilisation and design modifications in addressing the process of energy and exergy efficiency improvement. The primary focus is to enhance the economic and environmental performance through process analysis, modelling and optimisation. The paper is categorised into sections to show the contribution of each aspect clearly, namely: (a) Design and numerical study for innovative energy-efficient technologies; (b) Process Integration—heat and power; (c) Process energy efficiency or emissions analysis; (d) Optimisation of renewable energy resources supply chain. Each section is assessed based on the latest contribution of this journal’s Special Issue from the 21st conference on Process Integration, Modelling and Optimisation for Energy Saving and Pollution Reduction (PRES 2018). The key results are highlighted and summarised within the broader context of the state of the art development.