A Multi-Parameter Optimization Model for the Evaluation of Shale Gas Recovery Enhancement

Liu, Jia; Wang, Jingguo; Leung, C.F.; Gao, Feng

doi:10.3390/en11030654

Cited by 61 publications

(26 citation statements)

References 36 publications

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“…ese findings were slightly different from previously observed findings in other studies which showed that as the PEG 6000 concentration increased, drug release also increased for immediate release tablets [27]. is limited effect of PEG 6000 on the drug release might be due to the fast disintegration nature of the tablets and micronized form of glibenclamide used in this study [28].…”

Section: In Vitro Drug Releasecontrasting

confidence: 99%

“…ODTs. e selection was based on the comparisons of several statistical parameters including the coefficient of variation (CV), multiple correlation coefficient (R 2 ), adjusted multiple correlation coefficient (adjusted R 2 ), and predicted residual sum of squares (PRESS), provided by Design-Expert ® software [28]. Accordingly, the quadratic model and linear model were selected for friability and disintegration time, respectively.…”

Section: Response Model Selection a Mathematical Model Was Selected mentioning

confidence: 99%

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Formulation and Optimization of Monolithic Fixed-Dose Combination of Metformin HCl and Glibenclamide Orodispersible Tablets

Belayneh

Molla

Kahsay

2020

Advances in Pharmacological and Pharmaceutical Sciences

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e treatment of type II DM involves the use of combination of drugs, especially at the chronic stage. However, the pill burden of this combination therapy combined with swallowing difficulties, occurring at a later stage of DM, has been the major challenge for successful treatment outcomes. is study was aimed at formulating and optimizing a monolithic fixed-dose combination (FDC) of metformin (MET) and glibenclamide (GLB) orodispersible tablets (ODTs) to overcome both the pill burden and swallowing problems. e FDC ODTs were prepared by the melt granulation technique using polyethylene glycol (PEG) 6000 as a binding agent and crospovidone as a superdisintegrant. In the preliminary study, the effects of sodium lauryl sulphate (SLS), PEG 6000, crospovidone, and compression force on friability, disintegration time, and drug release of tablets were investigated. e FT-IR studies showed that there were no incompatibilities between MET and GLB as well as within excipients. e preliminary studies revealed that PEG 6000 and compression force significantly affect both the friability and the disintegration time, while SLS and crospovidone only affect the disintegration time. erefore, the effects of PEG 6000, crospovidone, and compression force were further studied and optimized using the central composite design. Accordingly, the most desirable optimal values were obtained at 3.82% of PEG 6000, 9.83% of crospovidone, and 10.6 kN compression force having a friability of 0.302% and a disintegration time of 18.7 seconds. From these results, it can be concluded that a monolithic FDC of MET and GLB ODTs having adequate mechanical strength and faster disintegration time was successfully formulated.

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Section: In Vitro Drug Releasecontrasting

confidence: 99%

Section: Response Model Selection a Mathematical Model Was Selected mentioning

confidence: 99%

Formulation and Optimization of Monolithic Fixed-Dose Combination of Metformin HCl and Glibenclamide Orodispersible Tablets

Belayneh

Molla

Kahsay

2020

Advances in Pharmacological and Pharmaceutical Sciences

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“…The initiation of hydraulic fractures and the stress distribution of shale reservoirs are also affected by the uniaxial compression strength (UCS) of shale, while cracks begin to extend when the stress intensity reaches or exceeds the fracture toughness of the shale [47,48]. The more organic matter content in shale with a lower UCS, the easier for cracks to initiate and extend forward during fracturing [49].…”

Section: Uniaxial Compression Failure Modesmentioning

confidence: 99%

Effective Exploitation Potential of Shale Gas from Lower Cambrian Niutitang Formation, Northwestern Hunan, China

et al. 2018

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The marine shale in the Lower Cambrian Niutitang Formation is the dominant shale-gas reservoir in northwestern Hunan, which accounts for more than 70% of unconventional energy in Hunan province. Accurately evaluating the shale-gas exploitation potential is a key to determining whether commercial exploitation standards can be met. In the literature, most existing studies have focused on evaluating the shale-gas exploitation potential based on either accumulation conditions or the shale fracability, which will lead to a gap between the real production and proven gas reserves due to the characteristics of the shale’s low permeability and low porosity. Therefore, further studies are needed to evaluate the effective shale-gas exploitation potential. To address this need, the outcrop shale samples in the Niutitang Formation were collected from the target regions, and the geological characteristics, mechanics behavior, and microstructure performance were discussed via both field data and laboratory tests. The results revealed that the shale-gas exploitation potential in the Niutitang Formation was indicated to be comparable to that of five validated shale-gas exploitation regions in the United States. To further illustrate the effective shale-gas exploitation potential, this study suggested using a comprehensive evaluation framework for this purpose, in which both accumulation condition and the shale fracability are simultaneously considered. Therefore, the shale gas reservoir in the Niutitang Formation has highly effective shale-gas exploitation potential by considering both the accumulation conditions and the shale fracability.

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“…Current mainstream technologies available for commercial development of shale gas are horizontal drilling plus hydraulic fracturing, which can largely enhance reservoir permeability [2][3][4][5][6]. After hydraulic fracturing, the gas production rate is dramatically enhanced in the short term but this high production rate drops quickly in the longer term [7]. For conventional gas reservoirs, single hydraulic fracturing mainly generates great-scale fractures from the preexisting fractures.…”

Section: Introductionmentioning

confidence: 99%

A Fully Coupled Numerical Model for Microwave Heating Enhanced Shale Gas Recovery

Liu,

Wang,

Leung

et al. 2018

Energies

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Formation heat treatment (FHT) can be achieved by converting electromagnetic energy into heat energy (that is microwave heating or MWH). Experimental evidence shows that such FHT can significantly enhance oil and gas recovery. As relatively few research studies have been reported on microwave heating enhanced shale gas recovery (MWH-EGR), a fully coupled electromagnetic-thermo-hydro-mechanical (ETHM) model is developed for the MWH-EGR in the present study. In the ETHM model, a thermal-induced gas adsorption model is firstly proposed for shale gas adsorption and fitted by experimental data. This thermal-induced adsorption model considers the increase of matrix pore space due to the desorption of the adsorbed phase. Further, a thermal-induced fracture model in shale matrix is established and fitted by experimental data. Finally, this ETHM model is applied to a fractured shale gas reservoir to simulate gas production. Numerical results indicated that the thermal-induced fracturing and gas desorption make predominant contributions to the evolution of matrix porosity. The MWH can increase cumulative gas production by 44.9% after 31.7 years through promoting gas desorption and matrix diffusion. These outcomes can provide effective insights into shale gas recovery enhancement by microwave assistance.

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A Multi-Parameter Optimization Model for the Evaluation of Shale Gas Recovery Enhancement

Cited by 61 publications

References 36 publications

Formulation and Optimization of Monolithic Fixed-Dose Combination of Metformin HCl and Glibenclamide Orodispersible Tablets

Formulation and Optimization of Monolithic Fixed-Dose Combination of Metformin HCl and Glibenclamide Orodispersible Tablets

Effective Exploitation Potential of Shale Gas from Lower Cambrian Niutitang Formation, Northwestern Hunan, China

A Fully Coupled Numerical Model for Microwave Heating Enhanced Shale Gas Recovery

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