Boon for the continuous support of my PhD study and research, for his patience, motivation, enthusiasm, and immense knowledge. Without his guidance and persistent help, this research would not have been possible. I would also like to thank Dr. Mohammad Omar Khyam, Dr. Md Noor-A-Rahim and Dr. Keng He Kong for guiding me throughout my PhD and suggesting novel ideas for implementation. I would like to thank all the people who helped me while collecting data and all subjects who willingly volunteered for the experiments. This project would not have been successful without their passionate participation. I would like to thank Mr. Long Tien Siew and Ms. Leow-How Seok Lai for their support to use the laboratories and facilities in NTU. I also thank my friends Rijil Thomas, Qi Yongbin and Aamani Budhota for all the help. Finally, I must express my very profound gratitude to my parents and to my friends for providing me with unfailing support and continuous encouragement throughout my years of study. This accomplishment would not have been possible without them. Thank you. xi "Imagination is more important than knowledge. Knowledge is limited. Imagination encircles the world."