A multi-step machine learning approach for accelerating QbD-based process development of protein spray drying

Fiedler, Daniela; Fink, Elisabeth; Aigner, Isabella; Leitinger, Gerd; Keller, Walter; Roblegg, Eva; Khinast, Johannes

doi:10.1016/j.ijpharm.2023.123133

Cited by 5 publications

(1 citation statement)

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“…Within the set of admissible solutions (parameter values), some may fulfill additional constraints, e.g., maximized sustainability of the process and product, or minimum production effort, as demonstrated by Przybyl and Kozela (e.g., deep and convolutional neural networks), [102] Ming et al (particle swarm optimization-enhanced artificial neural network), [103] or Fiedler et al (efficient design of experiments using a multi-step machine learning approach). [104] • Elucidation of fundamental relationships between operational, material parameters and product properties: Utilizing spray-drying data across different disciplines, e.g., material science, pharmaceuticals, or food and feed, AI methods may find fundamental relationships between the parameters and product properties, independent of the field of application. For this, a general open-access database, collecting and curating available experimental evidence across the applications, needs to be established by the spray-drying community (academia and industry).…”

Section: Spray-drying: Technical Advantages and Limitationsmentioning

confidence: 99%

Multifunctional, Hybrid Materials Design via Spray‐Drying: Much more than Just Drying

Wintzheimer,

Luthardt,

Cao

et al. 2023

Advanced Materials

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Spray‐drying is a popular and well‐known “drying tool” for engineers. This perspective highlights that, beyond this application, spray‐drying is a very interesting and powerful tool for materials chemists to enable the design of multifunctional and hybrid materials. Upon spray‐drying, the confined space of a liquid droplet is narrowed down, and its ingredients are forced together upon “falling dry.” As detailed in this article, this enables the following material formation strategies either individually or even in combination: nanoparticles and/or molecules can be assembled; precipitation reactions as well as chemical syntheses can be performed; and templated materials can be designed. Beyond this, fragile moieties can be processed, or “precursor materials” be prepared. Post‐treatment of spray‐dried objects eventually enables the next level in the design of complex materials. Using spray‐drying to design (particulate) materials comes with many advantages—but also with many challenges—all of which are outlined here. It is believed that multifunctional, hybrid materials, made via spray‐drying, enable very unique property combinations that are particularly highly promising in myriad applications—of which catalysis, diagnostics, purification, storage, and information are highlighted.

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Section: Spray-drying: Technical Advantages and Limitationsmentioning

confidence: 99%