A multicenter cohort study of total thyroidectomy and routine central lymph node dissection for cN0 papillary thyroid cancer

Popadich, Aleksandra; Levin, Olga; Lee, James Cheng Yen; Smooke-Praw, Stephanie; Ro, Kevin; Fazel, Maisam; Arora, Asit; Tolley, Neil; Palazzo, Fausto; Learoyd, Diana; Sidhu, Stanley; Delbridge, Leigh; Sywak, Mark; Yeh, Michael W.

doi:10.1016/j.surg.2011.09.003

Cited by 224 publications

(173 citation statements)

References 22 publications

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Section: Discussioncontrasting

confidence: 40%

“…In this study, the permanent hypoparathyroidism was documented in 6.5% for group A and 9.4% for group B patients which was much less than that reported by Tartaglia et al, 2014 25.4% of patients who underwent TT + CND, within the range reported by White et al, 20070-14.3% while Pereira et al, 2005Choi et al, 2011;Popadich et al,2011;Wang et al, 2013;and Lee et al, 2015 reported only 2%, 3% ,0.8%, 4.6% and 3.3% permanent hypoparathyroidism respectively. Temporary hypoparathyroidism was (Tartaglia et al, 2014), 6% (Wang et al, 2013) and 9.7% (Popadich et al, 2011) but sometimes as high as 60% (Pereira et al, 2005). In this study, the permanent VCD was documented in 3.2% in group A and 6.3% in group B which was within the reported range (0-12%) in other studies (Choi et al, 2011;Hughes and Doherty, 2011;Popadich et al, 2011;Giordano et al, 2012;Wang et al, 2013;Tartaglia et al, 2014;Lee et al, 2015), while temporary VCD was reported to be 12.9% in group A and 9.4% in group B which was slightly higher than the reported range (0.4-9%) in other studies (Pereira et al, 2005;Popadich et al, 2011;Wang et al, 2013;Tartaglia et al, 2014;Lee et al, 2015).…”

Section: Discussioncontrasting

confidence: 40%

“…Temporary hypoparathyroidism was (Tartaglia et al, 2014), 6% (Wang et al, 2013) and 9.7% (Popadich et al, 2011) but sometimes as high as 60% (Pereira et al, 2005). In this study, the permanent VCD was documented in 3.2% in group A and 6.3% in group B which was within the reported range (0-12%) in other studies (Choi et al, 2011;Hughes and Doherty, 2011;Popadich et al, 2011;Giordano et al, 2012;Wang et al, 2013;Tartaglia et al, 2014;Lee et al, 2015), while temporary VCD was reported to be 12.9% in group A and 9.4% in group B which was slightly higher than the reported range (0.4-9%) in other studies (Pereira et al, 2005;Popadich et al, 2011;Wang et al, 2013;Tartaglia et al, 2014;Lee et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

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Safety and Prognostic Impact of Prophylactic Level VII Lymph Node Dissection for Papillary Thyroid Carcinoma

Fayek

Kamel²,

Sidhom³

2016

Asian Pacific Journal of Cancer Prevention

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Asian Pac J Cancer Prev, 16 (18), 8425-8430 IntroductionPapillary thyroid cancer (PTC) is the most common type of thyroid cancer accounting for about 80% of all thyroid cancers, and is the fifth leading malignancy in females (Cisco et al., 2012;Siegel et al., 2013).Given the high rate of subclinical nodal metastases in PTC, many centers, have moved to routine prophylactic central nodal dissection (pCND) at the time of total thyroidectomy (TT) for all patients with PTC, pCND allows for more accurate assessment of nodal status, decreases the rate of local recurrence, reduces morbidity from reoperation if required, and may guide the dose of ablative postoperative radioiodine given (Mazzaferri EL Jhiang 1994;Scheumann et al., 1994;Hughes et al., 1996).Dralle (2012)

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Section: Discussioncontrasting

confidence: 40%

Section: Discussioncontrasting

confidence: 40%

Section: Discussionmentioning

confidence: 99%

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Safety and Prognostic Impact of Prophylactic Level VII Lymph Node Dissection for Papillary Thyroid Carcinoma

Fayek

Kamel²,

Sidhom³

2016

Asian Pacific Journal of Cancer Prevention

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“…According to Popadich et al (2011) the percentage of recurrent transient paralysis increased from 1.8% after TT to 2.3% after TT with CND, whereas the definitive rates range from 0.4% to 1.8%. For Giordano et al, 2012 transitional cases range from 3.6% to 5.5%, the definitive from 1% to 2.3%.…”

Section: Ihab Samy Fayekmentioning

confidence: 97%

Prophylactic Level VII Nodal Dissection as a Prognostic Factor in Papillary Thyroid Carcinoma: a Pilot Study of 27 Patients

Fayek

2015

Asian Pacific Journal of Cancer Prevention

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Background: Prognostic value of prophylactic level VII nodal dissection in papillary thyroid carcinoma has been highlighted. Materials and Methods: A total of 27 patients with papillary thyroid carcinoma with N0 neck underwent total thyroidectomy with level VI and VII nodal dissection through same collar neck incision. Multicentricity, bilaterality, extrathyroidal extension, level VI and VII lymph nodes were studied as separate and independent prognostic factors for DFS at 24 months. Results: 21 females and 6 males with a mean age of 34. Conclusions: Level VII prophylactic nodal dissection is an important and integral prognostic factor in papillary thyroid carcinoma. A larger multicenter study is crucial to reach a satisfactory conclusion about the necessity and safety of this approach.

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“…One single-center study has reported that routine central neck dissection might significantly reduce disease persistence or recurrence. 50) In a multicenter observational study by Popadich and colleagues, 51) …”

Section: Central Neck Dissectionmentioning

confidence: 99%

Regional Lymph Node Metastasis in Papillary Thyroid Cancer

Park

Lee

Bae

et al. 2014

J Korean Thyroid Assoc

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Papillary thyroid cancer is a common endocrine cancer and commonly presents with lymph node metastases. It has been generally accepted that lymphatic drainage occurs from the thyroid primarily to the central lymphatic compartment and secondarily to the lateral compartment nodes. Recently, improvements in the resolution of imaging studies and the availability of highly sensitive thyroglobulin assays have highlighted the importance of identifying disease in the pre-operative assessment and dealing effectively with metastatic regional disease in order to prevent recurrence. However, there are limitations to diagnosing central lymph node metastases. With unreliable imaging modalities, prophylactic central lymph node dissection should be performed on all patients with papillary thyroid cancer. In comparison with the central compartment, prophylactic lateral node dissection has little or no effect on improving the prognosis of patients with papillary thyroid cancer. Therefore, lateral node dissection is recommended only as a part of the therapeutic procedure. The extension of lateral neck dissection is recommended a comprehensive selective neck dissection of levels IIa, III, IV, and Vb. The rich lymphatic supply of the thyroid gland coupled with the propensity for nodal metastases in papillary thyroid cancer require the modern thyroid surgeon to be familiar with the indications for and techniques of regional lymph node dissection.

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A multicenter cohort study of total thyroidectomy and routine central lymph node dissection for cN0 papillary thyroid cancer

Cited by 224 publications

References 22 publications

Safety and Prognostic Impact of Prophylactic Level VII Lymph Node Dissection for Papillary Thyroid Carcinoma

Safety and Prognostic Impact of Prophylactic Level VII Lymph Node Dissection for Papillary Thyroid Carcinoma

Prophylactic Level VII Nodal Dissection as a Prognostic Factor in Papillary Thyroid Carcinoma: a Pilot Study of 27 Patients

Regional Lymph Node Metastasis in Papillary Thyroid Cancer

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