“…in younger subjects. 13 As always, in the elderly and medically ill, the use of a lower initial dose (e.g., 100 mg or 150 mg daily) and slower titration may be prudent, given the frequency of polypharmacy in the elderly and the effects of aging on pharmacokinetics. 14 A controlled trial of a relatively low dose of bupropion SR, 150 mg/day, thus may be worthwhile in geriatric depression.…”