A Multicenter, Open-Label, Observational Study of Testosterone Gel (1%) in the Treatment of Adolescent Boys With Klinefelter Syndrome or Anorchia

Rogol, Alan D.; Swerdloff, Ronald S.; Reiter, Edward O.; Ross, Judith L.; ZumBrunnen, Troy L.; Pratt, Gregg A.; Brennan, John J.; Benesh, Janet; Kan‐Dobrosky, Natalia; Miller, Michael G.

doi:10.1016/j.jadohealth.2013.07.021

Cited by 47 publications

(26 citation statements)

References 28 publications

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“…She believes that EHT is not a cure but does help significantly to minimize the boys' developmental challenges and behavioral issues based on her and other publications (Rogol et al, 2014;Samango-Sprouse et al, 2015).…”

Section: Testosterone and Other Treatmentsmentioning

confidence: 99%

The Klinefelter syndrome: current management and research challenges

et al. 2016

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Section: Testosterone and Other Treatmentsmentioning

confidence: 99%

The Klinefelter syndrome: current management and research challenges

et al. 2016

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“…Oral, transdermal [68] or intramuscular testosterone are the most commonly used regimes for pubertal induction, both in males with constitutional delay of puberty and for primary or secondary hypogonadism. Although most regimes suggest commencement of a low dose preparation, increasing slowly to adult doses over 2e3 years, some reports have utilized adult doses from outset.…”

Section: Treatmentmentioning

confidence: 99%

Pubertal induction in hypogonadism: Current approaches including use of gonadotrophins

Zacharin

2015

Best Practice & Research Clinical Endocrinology & Metab

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“…While gonadotropins are generally (but not always) suppressed after i.m. depot testosterone administration, no clinically significant changes in serum LH and FSH were noted in adolescents with KS receiving testosterone gels, despite the fact that total testosterone levels increased by 1.8-fold (54).…”

Section: Testosterone Dosingmentioning

confidence: 83%

“…I.m. injection of testosterone esters, given monthly up to 3 months (for the undecanoate formulation), still remains the most popular way of testosterone administration in adolescence and young adulthood, given its ease (54). Additionally, these preparations need daily application, which might favor a much lower compliance rate in adolescents.…”

Section: Testosterone Dosingmentioning

confidence: 99%

TRANSITION IN ENDOCRINOLOGY: Management of Klinefelter syndrome during transition

Gies

Unuane

Velkeniers

et al. 2014

European Journal of Endocrinology

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Klinefelter syndrome (KS) is the most common sex chromosomal disorder in males. Key findings in older adolescents and young men are small testes with variable hypo-androgenism, but almost universal azoospermia, most frequently in combination with a history of learning difficulties and behavior problems. Males with KS may come to medical attention through different medical presentations, given its association with several congenital malformations, and psychiatric, endocrine, and metabolic disorders. Preventive care is to be provided from diagnosis, preferentially through a multidisciplinary approach, including that from an endocrinologist, clinical psychologist or psychiatrist, neurologist, urologist, geneticist, sexologist, and a fertility team. Accurate information about the condition and assessment of associated medical conditions should be offered at diagnosis and should be followed by psychological counseling. Medical treatment during transition into adulthood is focused on fertility preservation and testosterone replacement therapy in the case of hypo-androgenism, and alleviation of current or future consequences of testicular fibrosis. However, more research is needed to determine the need for pro-active testosterone treatment in adolescence, as well as the conditions for an optimal testosterone replacement and sperm retrieval in adolescents and young men with KS. Furthermore, screening for associated diseases such as metabolic syndrome, autoimmune diseases, thyroid dysfunction, and malignancies is warranted during this period of life. The practical medical management during transition and, more specifically, the role of the endocrinologist are discussed in this article.

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A Multicenter, Open-Label, Observational Study of Testosterone Gel (1%) in the Treatment of Adolescent Boys With Klinefelter Syndrome or Anorchia

Cited by 47 publications

References 28 publications

The Klinefelter syndrome: current management and research challenges

The Klinefelter syndrome: current management and research challenges

Pubertal induction in hypogonadism: Current approaches including use of gonadotrophins

TRANSITION IN ENDOCRINOLOGY: Management of Klinefelter syndrome during transition

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