A multicenter randomized controlled trial to assess the feasibility of testing modified ultrafiltration as a blood conservation technology in cardiac surgery

Abstract

Modified ultrafiltration was effective for hemoconcentration after cardiopulmonary bypass in patients of low body weight, but it is associated with an increased need for vasopressor support. The anesthetist and intensivist were successfully blinded to the intervention.

Processed residual pump blood in cardiac surgery: the Processed Residual Blood in Cardiac surgery trial

“…22 A recent meta-analysis of randomized controlled trials by Boodhwani and colleagues 23 showed a significant reduction in postoperative blood transfusions and hemorrhage with ultrafiltration. However, the follow-up pilot randomized controlled trial of 65 patients from these authors 24 and our results provide no evidence of a benefit of ultrafiltration on hemorrhage and transfusion in adult CABG patients.…”

The Hemobag: the modern ultrafiltration system for patients undergoing cardiopulmonary by pass

“…In our observational study the group of patients treated with the Hemobag did not required higher vasopressor support after weaning the CPB or in the postoperative time, in contrast to the reported data in the literature of patients treated with modified ultrafiltration [20]. This may have occurred because the Hemobag ultrafiltration system could be started when the patients was hemodynamic stable after weaning from CPB.…”

Cardiovascular surgery in Jehovah's Witness patients: The role of preoperative optimization

“…6 Ultrafiltration not only provides hemoconcentration but also improves coagulation. 17 The higher hematocrit and concentration of coagulation factors, and removal of cytokines and toxins are favorable results of the use of ultrafiltration in bloodless CPB surgery. Appropriate use of non-blood-derived topical hemostatic agents and systemic hemostatic agents is beneficial in this patient population.…”