A multicenter study of nutraceutical drinks for cholesterol (evaluating effectiveness and tolerability)

Karl, Mitchell; Rubenstein, Mark H.; Rudnick, Chad; Brejda, John

doi:10.1016/j.jacl.2011.09.004

Cited by 21 publications

(16 citation statements)

References 27 publications

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“…All included trials were placebo-controlled, and the duration of treatment was 4 weeks or longer. Most of included trials were mono-centric except Karl 2012[20] and Yang 2009[25], which were multi-centric. Most of included trials were double-blinded except Marazzi 2011[22], which was single-blinded.…”

Section: Resultsmentioning

confidence: 99%

“…Most of included trials were double-blinded except Marazzi 2011[22], which was single-blinded. TC, TG, LDL-C, HDL-C were reported in most of trials except Huang 2007[27], in which only TC and LDL-C were reported and Karl 2012[20] in which only TC, LDL-C and HDL-C were reported. As presented in Table 1, 9 trials used compounds including red yeast rice (RYR), and 4 used RYR in intervention group, other ingredients and the doses of RYR and lovastatin (monacolin K) per day of every trial were also listed.…”

Section: Resultsmentioning

confidence: 99%

“…As presented in Table 1, 9 trials used compounds including red yeast rice (RYR), and 4 used RYR in intervention group, other ingredients and the doses of RYR and lovastatin (monacolin K) per day of every trial were also listed. Among the 13 included trials, 3 trials [18], [20], [25] adopted a three-armed group design. The 3 groups in Barrat 2012[18] were recommended daily dose group (6 tablets, including 1000 mg RYR), the typical dose group (3 tablets, including 500 mg RYR) or the placebo group; all groups were included in this meta-analysis.…”

Section: Resultsmentioning

confidence: 99%

“…The 3 groups in Barrat 2012[18] were recommended daily dose group (6 tablets, including 1000 mg RYR), the typical dose group (3 tablets, including 500 mg RYR) or the placebo group; all groups were included in this meta-analysis. The 3 groups in Karl 2012[20] were the RYR + Nutrition group, the Nutrition group, and the placebo group; only the RYR + Nutrition group and the placebo group were included in this meta-analysis. The 3 groups in Yang 2009[25] were the RYR + nattokinase group, the mono-nattokinase group, and the placebo group; only the RYR + nattokinase group and the placebo group were included in this meta-analysis.…”

Section: Resultsmentioning

confidence: 99%

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A Meta-Analysis of Red Yeast Rice: An Effective and Relatively Safe Alternative Approach for Dyslipidemia

et al. 2014

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ObjectiveTo explore whether red yeast rice is a safe and effective alternative approach for dyslipidemia.MethodsPubmed, the Cochrane Library, EBSCO host, Chinese VIP Information (VIP), China National Knowledge Infrastructure (CNKI), Wanfang Databases were searched for appropriate articles. Randomized trials of RYR (not including Xuezhikang and Zhibituo) and placebo as control in patients with dyslipidemia were considered. Two authors read all papers and independently extracted all relevant information. The primary outcomes were serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglyceride (TG), and high-density lipoprotein cholesterol (HDL-C). The secondary outcomes were increased levels of alanine transaminase, aspartate aminotransferase, creatine kinase, creatinine and fasting blood glucose.ResultsA total of 13 randomized, placebo-controlled trials containing 804 participants were analyzed. Red yeast rice exhibited significant lowering effects on serum TC [WMD = −0.97 (95% CI: −1.13, −0.80) mmol/L, P<0.001], TG [WMD = −0.23 (95% CI: −0.31, −0.14) mmol/L, P<0.001], and LDL-C [WMD = −0.87 (95% CI: −1.03, −0.71) mmol/L, P<0.001] but no significant increasing effect on HDL-C [WMD = 0.08 (95% CI: −0.02, 0.19) mmol/L, P = 0.11] compared with placebo. No serious side effects were reported in all trials.ConclusionsThe meta-analysis suggests that red yeast rice is an effective and relatively safe approach for dyslipidemia. However, further long-term, rigorously designed randomized controlled trials are still warranted before red yeast rice could be recommended to patients with dyslipidemia, especially as an alternative to statins.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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A Meta-Analysis of Red Yeast Rice: An Effective and Relatively Safe Alternative Approach for Dyslipidemia

et al. 2014

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“…45 The nutraceutical drink contained nominal amounts of niacin, phytosterol esters, l-carnitine, vitamin C, and CoQ-10. Fifty-nine healthy subjects who completed the study were initially randomized to the nutraceutical drink and red yeast rice, the nutraceutical drink only, or to placebo.…”

Section: Red Yeast Ricementioning

confidence: 99%

Statin Alternatives: A Review of Over-the-Counter Lipid-Lowering Supplements

DanaviJoseph¹,

MemonShermeen²,

Phan³

2015

Alternative and Complementary Therapies

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As the leading cause of death worldwide, cardiovascular disease has several modifiable risk factors, specifically dyslipidemia. Statin therapy has long been the mainstay treatment for dyslipidemia and has been demonstrated in various clinical trials to produce significant reductions in both major cardiovascular events and all-cause mortality. Given the changes per the 2013 American College of Cardiology/ American Heart Association guidelines on the treatment of cholesterol, it is estimated that even more people now qualify for statin therapy. This can be problematic, as there is a sizeable population of patients whom are either statin-intolerant or prefer an alternative approach. The aim of this review is to describe the clinical trial data evaluating over-thecounter supplements including garlic (Allium sativum), green tea (Camellia sinensis) extract, guggul, red yeast (Monascus purpureus) rice, and niacin as alternative therapies for treating dyslipidemia. Research from current trials has shown that these supplements improve lipid profiles; however additional studies are needed to better establish their safety and clinical efficacy.

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Fungus Monascus-Fermented Red Yeast Rice (RYR): Natural Therapeutic Statin Source or Mycotoxin?

Patel

Akhtar

2018

Fungi and Their Role in Sustainable Development: Current Perspectives

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A multicenter study of nutraceutical drinks for cholesterol (evaluating effectiveness and tolerability)

Cited by 21 publications

References 27 publications

A Meta-Analysis of Red Yeast Rice: An Effective and Relatively Safe Alternative Approach for Dyslipidemia

A Meta-Analysis of Red Yeast Rice: An Effective and Relatively Safe Alternative Approach for Dyslipidemia

Statin Alternatives: A Review of Over-the-Counter Lipid-Lowering Supplements

Fungus Monascus-Fermented Red Yeast Rice (RYR): Natural Therapeutic Statin Source or Mycotoxin?

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