A multicenter study of primary brain tumor incidence in Australia (2000–2008)

Abstract

There are conflicting reports from Europe and North America regarding trends in the incidence of primary brain tumor, whereas the incidence of primary brain tumors in Australia is currently unknown. We aimed to determine the incidence in Australia with age-, sex-, and benign-versus-malignant histology-specific analyses. A multicenter study was performed in the state of New South Wales (NSW) and the Australian Capital Territory (ACT), which has a combined population of >7 million with >97% rate of population retention for medical care. We retrospectively mined pathology databases servicing neurosurgical centers in NSW and ACT for histologically confirmed primary brain tumors diagnosed from January 2000 through December 2008. Data were weighted for patient outflow and data completeness. Incidence rates were age standardized and trends analyzed using joinpoint analysis. A weighted total of 7651 primary brain tumors were analyzed. The overall US-standardized incidence of primary brain tumors was 11.3 cases 100 000 person-years (±0.13; 95% confidence interval, 9.8-12.3) during the study period with no significant linear increase. A significant increase in primary malignant brain tumors from 2000 to 2008 was observed; this appears to be largely due to an increase in malignant tumor incidence in the ≥65-year age group. This collection represents the most contemporary data on primary brain tumor incidence in Australia. Whether the observed increase in malignant primary brain tumors, particularly in persons aged ≥65 years, is due to improved detection, diagnosis, and care delivery or a true change in incidence remains undetermined. We recommend a direct, uniform, and centralized approach to monitoring primary brain tumor incidence that can be independent of multiple interstate cancer registries.

Epidemiology of Primary CNS Tumors in Iran: A Systematic Review

“…In Saskatchewan, between 1970 to 2001, the incidence of primary brain tumors was 11.1 per 100,000 persons: 12.5 for males and 9.8 for females (Pirouzmand and Sadanand, 2007). In registries of Australia from 2000 to 2008 the overall incidence of primary brain tumors was 11.3 per 100,000 person-years (Dobes et al, 2011).…”

“…The highest rates of incidence are seen in North America, Australia (Dobes et al, 2011), and Western Europe, (Deltour et al, 2009) and the lowest incidences are reported in Asia, Central and South American regions (Ferlay et al, 2010). The GLOBOCAN 2008 study published in 2010, estimated the highest incidence of primary brain tumors in North Europe, and the lowest incidence in Eastern Africa (Ferlay et al, 2010).…”

“…For the first time, a CNS tumor registry was begun in 1902 by Harvey Cushing (Wahl et al, 2009) and subsequently the registry expanded to other countries. The epidemiologic data from 1 1 , Rashid Ramezani 5 such registries has been published in the US, Canada, France, Denmark, Norway, Finland, Sweden, Australia, India, Korea and Japan (Davis et al, 1999;Kaneko et al, 2002;Bauchet et al, 2007;Pirouzmand and Sadanand, 2007;Deltour et al, 2009;Lee et al, 2010;Baldi et al, 2011;Dobes et al, 2011;Manoharan et al, 2012).…”

Epidemiology of Malignant and Non-Malignant Primary Brain Tumors in Jordan

“…Overall, the incidence rate of primary brain tumors is higher in developed countries than that in developing nations [4]. It has been postulated that these differences could be in part related to the economy of the country, as the highest incidence rates are observed in Western Europe, North America and Australia [22,23], whereas the lowest rates are registered in Eastern Africa [24]. Nevertheless, differences in the CIRs of brain tumors between developed and developing countries could also be partially attributed to differences in the age distribution between countries as the incidence rate of most brain tumors gradually increases with age.…”

Trends in incidence of primary brain cancer in New Zealand, 1995 to 2010

“…In Osaka, Japan, rates at ages 20–74 increased from 1975 to 1988, and at ages 75+ increased until 1984, but then stabilised; these changes were attributed to diagnostic improvements 11 . A recent study in Australia based on clinical data showed some increases 12,13 . No increases were seen from 1986 to 1998 in a previous study in New Zealand (NZ) 14 .…”