A multicenter study on extramammary Paget’s disease in Korea

Abstract

Background There has been little research on extramammary Paget's disease (EMPD)

Management of Penoscrotal Extramammary Paget Disease: Case Series and Review of the Literature

“…In retrospective cohorts, the number of cases accumulating over a period of time seemed to be higher than was seen in Western studies. It is unclear if there is a racial or environmental reason behind the difference 20 . The correlation of cea levels with tumour progression in advanced empd 21 is commonly described in Asian series.…”

“…That technique consists of removal of tumour, review of margins under the microscope by the surgeon, tumour mapping, and resection of positive margins, potentially sparing normal tissue while achieving complete tumour resection 44 . Additionally, the reported recurrence rates are lower after Mohs micrographic surgery than after conventional excision (12.5%-28% vs. 33%-60%) 20,43,45,46 . When surgical margins are negative, patients experience durable relapse-free survival.…”

“…e311-320; doi: http://dx.doi.org/10.3747/co. 20 fungating cancer of the right groin, extending to the scrotum and upper thigh. The patient underwent a partial scrotectomy and excision of the overlying skin of the right medial thigh.…”

Enfermedad de Paget extramamaria: 10 casos

“…CK: inmunotinción con queratinas de bajo y alto peso molecular (AE1 y AE3) con positividad en la epidermis, el epitelio folicular y más intensa en las células de Paget con invasión por células individuales y en pequeños grupos de la dermis reticular (× 4). se relaciona con cáncer anexial subyacente en el 24-33% de los casos, y visceral en el 12-15% incluyendo tumores gastrointestinales y del tracto urinario, principalmente en órganos con revestimiento contiguo, siendo más frecuente en la forma perianal 6,10 . Los tumores generalmente asociados son de mama, vejiga y cuello uterino, pero también de recto, colon, próstata, ovarios, uretra, vagina, endometrio y riñón 6 .…”

Extensive invasive extramammary Paget′s disease: Surgical treatment

“…[7] The percentage of secondary tumours is 14.4% in South Korea. [8] The highest increased risk of developing a second primary tumour was found in the first year of follow-up or being female. These findings argue for thorough search for other tumours during follow-up.…”