A multicentre longitudinal observational study of changes in self reported health status in people with Parkinson's disease left untreated at diagnosis

Grosset, Donald G.; Taurah, LS; Burn, David J.; MacMahon, Doug; Forbes, Alison; Turner, Kimberly A.; Bowron, A; Walker, Richard; Findley, Leslie J.; Föster, O; Patel, Keni B.; Clough, Chris; Castleton, Beverly; Smith, Sandy; Carey, Gillian; Murphy, Terrence E.; Hill, Julie; Brechany, Una; McGee, Paula; Reading, Stacey; Brand, Gérard; Kelly, Linda; Breen, Kieran C.; Ford, Steve; Baker, Mary; Williams, Adrian J.; Hearne, J. Cockle; Qizilbash, Nawab; Chaudhuri, K. Ray

doi:10.1136/jnnp.2006.098327

Cited by 154 publications

(98 citation statements)

References 19 publications

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“…Most of the study participants were married (30), white (32), with low levels of education -primary school (23), presented a moderate degree of disease impairment (28) and made use of dopamine (26).…”

Section: Resultsmentioning

confidence: 99%

“…It is interesting to observe that the motor symptoms were no longer exclusively considered the important determiners of QoL of the PD patients, but also the nonmotor ones, since the progression of the disease brings new alterations that certainly lead to the impairment of other QoL dimensions. The deterioration starts to be observed in the cognition, bodily discomfort, emotions and communication dimensions (5,9,(23)(24) .…”

Section: Discussionmentioning

confidence: 99%

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Quality of life of a person with Parkinson's disease and the relationship between the time of evolution and the severity of the disease

Navarro-Peternella

Marcon

2012

Rev. Latino-Am. Enfermagem

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Parkinson's disease can cause disability and decrease the quality of life in its sufferers. The aim of this study was to evaluate the quality of life of a group of people with Parkinson's disease and whether a relationship exists between time of evolution and severity of the disease. Secondary analysis was carried out on transversal data collected from 40 individuals with Parkinson's disease registered in the Parkinson's Association of Maringá, in Maringá-PR-Brazil. Measures: three instruments were applied: a socio-demographic questionnaire, the Hoenh and Yahr Scale and the Parkinson's Disease Questionnaire (PDQ-39). According to PDQ-39, men referred to a lower quality of life, although, statistically, there was no significant difference between the two genders. Differences were only observed in the dimensions of "activities of daily living" and "social support", in which men presented higher impairment, and "emotions" and "bodily discomfort", where women showed higher impairment. Furthermore, severity of disease tended to lead to a perception of lower quality of life regarding the dimensions of "activities of daily living" and "cognition", which is relevant to improve clinical guidance and intervention. diária" e "apoio social", com os homens apresentando maior acometimento e "bem-estar emocional" e "desconforto corporal", com maior comprometimento entre as mulheres.Por outro lado, a gravidade da doença apresentou tendência a pior percepção na qualidade de vida nas dimensões atividades de vida diária e cognição, pontos relevantes para melhor orientação clínica e intervenção.Descritores: Doença de Parkinson; Doença Crônica; Qualidade de Vida. Calidad de vida de las personas con enfermedad de Parkinson y su relación con la evolución en el tiempo y la gravedad de la enfermedadLa enfermedad de Parkinson puede llegar a ser incapacitante y afectar a la calidad de vida de los pacientes. El objetivo de este estudio fue evaluar la calidad de vida de las personas con Parkinson e identificar las relaciones con el transcurso del tiempo y la gravedad de la enfermedad. Los datos fueron recogidos en la ciudad de Maringá-PRBrasil, con 40 personas indexadas en la "Associação Maringaense de Parkinson", a través de la aplicación de tres instrumentos: cuestionario sociodemográfico, escala de Hoenh e Yahr y PDQ-39. De acuerdo con el PDQ-39, los hombres reportaron peor calidad de vida, aunque no hubo diferencias estadísticas entre los sexos. Las diferencias apenas se observaron en la dimensión "actividades de vida diaria" y "apoyo social", con los hombres presentando una mayor participación y "bienestar emocional" e "incomodidad física" con una más grave entre las mujeres. Por otra parte, la gravedad de la enfermedad mostró una tendencia a empeorar la percepción en la calidad de vida en las dimensiones de las actividades de la vida diaria y cognición, puntos importantes para una mejor orientación e intervención clínica.Descriptores: Enfermedad de Parkinson; Enfermedad Cronica; Calidad de Vida.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Quality of life of a person with Parkinson's disease and the relationship between the time of evolution and the severity of the disease

Navarro-Peternella

Marcon

2012

Rev. Latino-Am. Enfermagem

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“…First, the rate of clinical deterioration in PD may be rapid in the early stages, with a decline of~8 --10 Unified Parkinson's Disease Rating Scale (UPDRS) points in the first year after diagnosis [6], and patients with lower Hoehn and Yahr (HY) or UPDRS motor scores at baseline have been shown to have greater progression of motor impairment than those with higher disease severity at baseline [7], suggesting this early period after diagnosis is critical for treatment intervention. Moreover, evidence suggests that earlier intervention of PD treatment may lead to better long-term motor benefit [8][9][10]; and has also been shown to maintain PD-related quality of life compared to postponing treatment, which may result in a deterioration of PD-related quality of life [11]. While there are no established disease-modifying or 'neuroprotective' therapies [12], timing of therapy initiation is thus of clinical importance.…”

Section: Introductionmentioning

confidence: 99%

Impact of 6-month earlier versus postponed initiation of rotigotine on long-term outcome:post hocanalysis of patients with early Parkinson’s disease with mild symptom severity

Timmermann¹,

Asgharnejad²,

Boroojerdi³

et al. 2015

Expert Opinion on Pharmacotherapy

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“…The goal of medical management of PD is to provide control of signs and symptoms for as long as possible while minimizing of adverse effects is occurred. Latest studies demonstrate that a patient's quality of life deteriorates quickly if treatment is not instituted at or shortly after diagnosis [15]. The main criterion for the evaluation is the diagnostic accuracy.…”

Section: The General Structure Of the Proposed Modelmentioning

confidence: 99%

An Integrated Ontology-Based Model for the Early Diagnosis of Parkinson’s Disease

Alexiou

Psiha

Vlamos

2012

IFIP Advances in Information and Communication Technology

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Abstract. In our days there is no single test or biomarker that can predict whether a particular person will develop Parkinson Disease and a definitive diagnosis is only possible after death, with postmortem analysis. Recent discoveries have highlighted that defects in mitochondrial dynamics are associated with neurodegenerative disease. In this paper the general architecture of an integrated multi-scale ontology-based modeling technology for early diagnosis of PD and for progress monitoring is proposed. The proposed model will be used to identify physics and biology-based biomarkers of processes occurring at radically different scales, from cell to whole body.

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A multicentre longitudinal observational study of changes in self reported health status in people with Parkinson's disease left untreated at diagnosis

Cited by 154 publications

References 19 publications

Quality of life of a person with Parkinson's disease and the relationship between the time of evolution and the severity of the disease

Quality of life of a person with Parkinson's disease and the relationship between the time of evolution and the severity of the disease

Impact of 6-month earlier versus postponed initiation of rotigotine on long-term outcome:post hocanalysis of patients with early Parkinson’s disease with mild symptom severity

An Integrated Ontology-Based Model for the Early Diagnosis of Parkinson’s Disease

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