A Multicentre, Prospective Study to Evaluate Costs of Septic Patients in Brazilian Intensive Care Units

Sogayar, Ana Maria Cristina B.; Machado, Flávia Ribeiro; Réa-Neto, Álvaro; Dornas, Amselmo; Grion, Cíntia Magalhães Carvalho; Lobo, Suzana M.; Tura, Bernardo Rangel; Silva, Carla L. O.; Cal, Ruy Guilherme Rodrigues; Beer, Idal; Michels, V; Safi, Jorge; Kayath, Marcia J.; Silva, Eliezer

doi:10.2165/00019053-200826050-00006

Cited by 112 publications

(99 citation statements)

References 9 publications

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“…During a year, participants were followed from diagnosis of sepsis until the clinical outcome and the direct hospitalization costs were estimated. The results showed an average total cost per patient of US$ 9,632.00 (R$ 21,566.00) (11) . This value is below that calculated in the current study, which was R$ 38,867.6 (US$ 17,359.30) per septic patient, on average.…”

Section: Discussionmentioning

confidence: 99%

Sepsis in a university hospital: a prospective study for the cost analysis of patients' hospitalization

Barreto

Dellaroza

Kerbauy

et al. 2016

Rev. esc. enferm. USP

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Objective: To estimate the cost of hospitalization of patients with severe sepsis or septic shock admitted or diagnosed in the Urgent and Emergency sector at a university hospital and followed until the clinical outcome. Method: An epidemiological, prospective, observational study conducted in a public hospital in southern Brazil for the period of one year (August 2013 to August 2014). Sepsis notification forms, medical records and data of the cost sector were used for the collection of clinical and epidemiological data. Results: The sample comprised 95 patients, resulting in a total high cost of hospitalization (R$ 3,692,421.00), and an average of R$ 38,867.60 per patient. Over half of the total value of the treatment of sepsis (R$ 2,215,773.50) was assigned to patients who progressed to death (59.0%). The higher costs were related to discharge, diagnosis of severe sepsis, the pulmonary focus of infection and the age group of up to 59 years. Conclusion: The high cost of the treatment of sepsis justifies investments in training actions and institution of protocols that can direct preventive actions, and optimize diagnosis and treatment in infected and septic patients. Sepsis in a university hospital: a prospective study for the cost analysis of patients' hospitalization Sepse em um hospital universitário: estudo prospectivo para análise de custo da hospitalização de pacientes Sepsis en un hospital universitario: estudio prospectivo para análisis de costo de la hospitalización de pacientes

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Section: Discussionmentioning

confidence: 99%

Sepsis in a university hospital: a prospective study for the cost analysis of patients' hospitalization

Barreto

Dellaroza

Kerbauy

et al. 2016

Rev. esc. enferm. USP

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show abstract

“…In a Norwegian University hospital setting, Flaatten and Kvale [41] determined average costs of an ICU day at € 2601,00. More recently, for the South American continent, Sogayar et al [42] evaluated the costs of ICU treatment of septic patients in Brazil, concluding that the median daily ICU cost per patient was $US 934,00, but that this was even higher, namely $US 1.094,00, for non-survivors. In a Canadian study on published and institutional data, Muscedere et al [43] described an ICU bed as costing CAN dollars 2.396,00 per day.…”

Section: Discussionmentioning

confidence: 99%

Non-Equivalence of Antibiotic Generic Drugs and Risk for Intensive Care Patients

C¹

2013

Pharmaceut Reg Affairs

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Background: The underlying axiom in applying generic drugs is the equivalence of their active ingredient with the (usually more expensive) innovator product, an all-embracing statement with the insidious result that physicians assume that the generic products have been subjected to the same rigorous testing regimens as the brand-name products. The present paper presents novel experimental data on an investigator-blinded comparison between the innovator imipenem antibiotic, and a number of its generics.

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“…Although the great therapeutic available, it is the major cause of death in most ICUs and the leading cause of acute kidney injury [2,3]. The choice of antibiotics and when start support measures (such as mechanical ventilation and vasoactive drugs) is a challenge because of the difficult clinical management, caused by hemodynamic changes and electrolyte resulting from this state [4,5].…”

Section: Introductionmentioning

confidence: 99%

Aloe vera delays mortality, but does not attenuate kidney injury in septic mices

et al. 2016

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Background: Intensive care units (ICUs) admissions due to sepsis represent 2 to 11%. Although there are well stablished therapeutic available, it still is the major cause of death in most ICUs and the leading cause of acute kidney injury. The objective of this work was to evaluate the role of Aloe vera extract on survival rates and kidney histopathology of mice submitted to sepsis induced by cecal ligation and puncture. Methods and Findings:Twenty six mice were distributed into four groups: Sham -surgery simulation (N=5); Control -Cecal ligation and puncture was performed (N=7); Aloe -Surgery simulation and treatment with Aloe vera extract (N=7); and Sepsis + Aloe -Cecal ligation and puncture was performed followed by treatment with Aloe vera extract (N=7). The animals were observed until death. Kidneys were analysed by histopathology. Kruskall-Wallis test was used to compare the histopathological results. Survival analysis was assessed by Kaplan-Meier statistics and compared using log rank test. A significance level of 5% was adopted. The survival time ranged from 19 hours for the Control group up to 24 hours for the animals of Sepsis + Aloe group, corresponding to a survival time of 1.26 times greater (p<0.01). There were no difference between the Sham and Aloe groups and between Control and Sepsis + Aloe groups according to the four parameters analyzed (p>0.05). Conclusions:Aloe vera delays mortality but does not attenuate kidney injury.

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A Multicentre, Prospective Study to Evaluate Costs of Septic Patients in Brazilian Intensive Care Units

Cited by 112 publications

References 9 publications

Sepsis in a university hospital: a prospective study for the cost analysis of patients' hospitalization

Sepsis in a university hospital: a prospective study for the cost analysis of patients' hospitalization

Non-Equivalence of Antibiotic Generic Drugs and Risk for Intensive Care Patients

Aloe vera delays mortality, but does not attenuate kidney injury in septic mices

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