A multiclass method for the determination of pharmaceuticals in drinking water by solid phase extraction and ultra-high performance liquid chromatography-tandem mass spectrometry

Oliveira, Júlia A. de; Izeppi, Lenise Janaina Pertile; Loose, Roberta Fabricio; Muenchen, Daniela K.; Prestes, Osmar D.; Zanella, Renato

doi:10.1039/c9ay00289h

Cited by 20 publications

(3 citation statements)

References 22 publications

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“…The SPE recoveries obtained by optimization of water sample volume, initial pH value and elution solvent are presented in Fig 4 . The SPE method is considered to be efficient if the obtained recovery values fall within 70 -120 %, with relative standard deviation (RSD) ≤ 20 %. 14,[33][34][35][36] The most suitable recoveries of selected analytes were obtained for 100 cm 3 of water samples, and for all analytes, except dimethoate, diazepam, and atrazine, obtained recoveries ranged from 70 to 119 % (Fig 4a).…”

Section: Activated Carbonized Beech Sawdust Samples As An Adsorbent In Solid-phase Extractionmentioning

confidence: 95%

Beech sawdust based adsorbents for solid-phase extraction of pesticides and pharmaceuticals

Vukčević

Maletić²,

Đurkić

et al. 2022

JSCS

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Carbonaceous solid-phase extraction (SPE) sorbent, efficient in isolation and enrichment of multiclass pesticides and pharmaceuticals from water, was synthesized starting from cheap waste beech sawdust and using KOH as the activated agent. The first step in carbon material preparation was hydrothermal carbonization of the waste beech sawdust. Following hydrothermal treatment, the obtained material was activated, using different amounts of KOH. It was found that applied activation leads to changes in material structure, an increase in specific surface area, and a decrease in the number of surface oxygen groups compared to carbonized sample. SPE procedure of multiclass pesticides and pharmaceuticals from water using activated carbonized beech sawdust (AcSD) was optimized by selecting the appropriate elution solvents, the sample pH, and the sample volume to obtain the highest enrichment efficiency. The optimized SPE procedure was applied for water analysis using different AcSD samples as a sorbent for analyte preconcentration. Activated carbon sorbent, obtained with the highest amount of KOH, showed the highest recoveries regarding the most analytes, which were comparable with the recoveries obtained by commercial cartridges.

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Section: Activated Carbonized Beech Sawdust Samples As An Adsorbent In Solid-phase Extractionmentioning

confidence: 95%

Beech sawdust based adsorbents for solid-phase extraction of pesticides and pharmaceuticals

Vukčević

Maletić²,

Đurkić

et al. 2022

JSCS

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“…The UHPLC-MS/MS conditions were electrospray ionization in positive and negative modes, capillary voltage 2 kV, desolvation gas temperature 500°C, desolvation gas flow (nitrogen) 600 L/h, spray flow 80 L/h, collision gas flow (argon) 0.15 mL/min and source temperature 150°C (Donato et al 2017). Despite the same method being implemented to detect and determine pharmaceuticals, there were subtle variations, following Oliveira et al (2019).…”

Section: Pesticide and Pharmaceutical Determinationmentioning

confidence: 99%

Terrestrial protected areas do not fully shield their streams from exogenous stressors

Mollmann

Santos²,

Fernandes³

et al. 2022

Envir. Conserv.

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Summary Protected areas (PAs) represent a powerful refuge for maintaining and safeguarding biodiversity. Generally, PAs are delineated to protect terrestrial taxa, providing incidental protection to the aquatic ecosystems within their borders. Here, we compare water quality within PAs and non-PAs in southern Brazil, encompassing remnants of the Atlantic Forest biome, to assess whether PAs serve as a buffer from external pressures for aquatic ecosystems within their boundaries. In addition to physicochemical and microbiological water parameters, we analysed 147 pesticide and 31 pharmaceutical compounds in water samples from 33 sites within and outside PAs. The water quality did not differ between PAs and non-PAs but indicated clear pollution from sewage discharges. We found 19 pesticides and five pharmaceuticals in streams within the study area. We detected pesticides in all sampling sites, with the herbicide 2,4-dichlorophenoxyacetic acid present in 91% of them. Our data show that PAs are insufficient means to mitigate the impacts stemming from their catchments, and the running water that reaches their domains already shows signs of anthropogenic interference, which may affect aquatic biodiversity. Protection and management measures require consideration of the whole watershed to protect freshwater habitats and biota.

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“…Beta-blockers have been detected in wastewater and surface waters by some researchers worldwide [19,20]. The most widely used analytical technique for determination of pharmaceutical compounds including beta blockers in environmental waters is liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) because of its high specificity and sensitivity [20][21][22][23][24][25]. The metabolites of beta-blockers are rarely investigated in wastewater or surface water due to lack of standards or lack of adequate methods for analyzing these emerging contaminants.…”

Section: Introductionmentioning

confidence: 99%

Liquid Phase Chromatographic Methods Applied to Determine Emerging Contaminants in Environmental Samples

Iancu

Petre

Galaon

et al. 2020

RJEEC

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Emerging contaminants are a heterogeneous group of chemicals that include daily personal care products and pharmaceuticals (PPCPs), flame retardants, endocrine-disrupting chemicals (EDCs) and nanoparticles (NPs) present in environment which are unregulated. In this review, we present the methods of analysis conducted by INCD-ECOIND regarding some classes of emerging contaminants (neonicotinoid pesticides, beta-blocker drugs) that are not regulated by the legislation, in different types of environmental samples (wastewater, surface water). The present review presents the selective solid-phase extraction (SPE) methods used for isolation of the targeted compounds from aqueous matrices and also the main instrumental parameters of the separation and detection process. After extraction, the compounds were subjected to liquid phase chromatographic separation with mass spectrometric detection (UHPLC-MS/MS). Finally, the methods were applied in the determination of compounds from different categories of water, carrying out studies on the efficiency of elimination of compounds in several municipal wastewater treatment plants (WWTPs). In addition, the impact of the treatment plants on some receiving surface water used to obtain drinking water was studied.

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A multiclass method for the determination of pharmaceuticals in drinking water by solid phase extraction and ultra-high performance liquid chromatography-tandem mass spectrometry

Abstract: A fast method for multiclass determination of 20 pharmaceuticals in drinking water using SPE with a polymeric sorbent and UHPLC-MS/MS was developed and validated.

Cited by 20 publications

References 22 publications

Beech sawdust based adsorbents for solid-phase extraction of pesticides and pharmaceuticals

Beech sawdust based adsorbents for solid-phase extraction of pesticides and pharmaceuticals

Terrestrial protected areas do not fully shield their streams from exogenous stressors

Liquid Phase Chromatographic Methods Applied to Determine Emerging Contaminants in Environmental Samples

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