A multicohort, longitudinal study of cerebellar development in attention deficit hyperactivity disorder

Shaw, Philip; Ishii-Takahashi, Ayaka; Park, Min Tae M.; Devenyi, Gabriel A.; Zibman, Chava; Kasparek, Steven William; Sudre, Gustavo; Mangalmurti, Aman; Hoogman, Martine; Tiemeier, Henning; Polier, Georg G. von; Shook, Devon; Muetzel, Ryan L.; Chakravarty, M. Mallar; Konrad, Kerstin; Durston, Sarah; White, Tonya

doi:10.1111/jcpp.12920

Cited by 39 publications

(32 citation statements)

References 47 publications

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“…Case-control differences were not significant in adult males. This result corroborates the earlier findings that developmental brain-structural differences observed with MRI in ADHD may normalize in adulthood (11,28,29).…”

Section: Discussionsupporting

confidence: 92%

“…In the present study, four communities were observed in boys with and without ADHD and in men with ADHD, while in healthy men, only three communities were present. It seemed like community structure in healthy men simplified from four to three communities, whilst patients retained a four-community distribution; this may be consistent with findings of delayed maturation in ADHD (11,28,29), but more research in longitudinal samples is clearly needed.…”

Section: Discussionsupporting

confidence: 73%

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Characterizing neuroanatomic heterogeneity in people with and without ADHD based on subcortical brain volumes

Rooij

Mota

et al. 2019

Preprint

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Background: Attention-Deficit/Hyperactivity Disorder (ADHD) is a prevalent neurodevelopmental disorder in children and adults. Neuroanatomic heterogeneity limits our understanding of the etiology of ADHD. This study aimed to parse neuroanatomic heterogeneity of ADHD, and to determine whether subgroups could be discerned in patients based on subcortical volumes. Methods:Using the dataset from the ENIGMA-ADHD Working Group, we applied exploratory factor analysis (EFA) to subcortical volumes of 993 boys with and without ADHD, and to subsamples of 653 adult men, 400 girls, and 447 women. Factor scores derived from the EFA were used to build networks.A community detection (CD) algorithm clustered participants into subgroups based on the networks.Results: Three factors (basal ganglia, limbic system, and thalamus) were found in boys and men with and without ADHD. The factor structures for girls and women differed from those in males. Given sample size considerations, we concentrated subsequent analyses on males. Male participants could be separated into four communities, though Community 3 was absent in healthy men. Significantly casecontrol differences of subcortical volumes were observed within communities in boys with increased effect sizes, but not in men. While we found no significant differences in ADHD symptom severity between communities in boys or men; affected men in Community 1 and 4 presented comorbidities more frequently than those in other communities. Conclusion:Our results indicate that neuroanatomic heterogeneity in subcortical volumes exists, irrespective of ADHD diagnosis. Effect sizes of case-control differences appear more pronounced at least in some of the subgroups.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 73%

Characterizing neuroanatomic heterogeneity in people with and without ADHD based on subcortical brain volumes

Rooij

Mota

et al. 2019

Preprint

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“…The ENIGMA-ADHD WG was the first WG in ENIGMA to perform a detailed investigation of the casecontrol effects on the cerebellum. Differential age trajectories were identified for children with ADHD when compared with typically developing children for the corpus medullare 93 .…”

Section: Enigma-attention-deficit/hyperactivity Disordermentioning

confidence: 99%

ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries

Thompson¹,

Jahanshad²,

Ching³

et al. 2020

Transl Psychiatry

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This review summarizes the last decade of work by the ENIGMA (Enhancing NeuroImaging Genetics through Meta Analysis) Consortium, a global alliance of over 1400 scientists across 43 countries, studying the human brain in health and disease. Building on large-scale genetic studies that discovered the first robustly replicated genetic loci associated with brain metrics, ENIGMA has diversified into over 50 working groups (WGs), pooling worldwide data and expertise to answer fundamental questions in neuroscience, psychiatry, neurology, and genetics. Most ENIGMA WGs focus on specific psychiatric and neurological conditions, other WGs study normal variation due to sex and gender differences, or development and aging; still other WGs develop methodological pipelines and tools to facilitate harmonized analyses of "big data" (i.e., genetic and epigenetic data, multimodal MRI, and electroencephalography data). These international efforts have yielded the largest neuroimaging studies to date in schizophrenia, bipolar disorder, major depressive disorder, post-traumatic stress disorder, substance use disorders, obsessive-compulsive disorder, attentiondeficit/hyperactivity disorder, autism spectrum disorders, epilepsy, and 22q11.2 deletion syndrome. More recent ENIGMA WGs have formed to study anxiety disorders, suicidal thoughts and behavior, sleep and insomnia, eating disorders, irritability, brain injury, antisocial personality and conduct disorder, and dissociative identity disorder. Here, we summarize the first decade of ENIGMA's activities and ongoing projects, and describe the successes and challenges encountered along the way. We highlight the advantages of collaborative large-scale coordinated data analyses for testing reproducibility and robustness of findings, offering the opportunity to identify brain systems involved in clinical syndromes across diverse samples and associated genetic, environmental, demographic, cognitive, and psychosocial factors.

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“…Because peers trigger socioemotional brain systems by activating reward-related regions like the ventral striatum (Chein et al, 2011 ; Gardner & Steinberg, 2005 ; Somerville, 2013 ), and peer presence is associated with an increase in the subjective value of immediate rewards (Albert et al, 2013 ), more cognitive control is required to control behavior in the presence of peers. As ADHD is characterized by pronounced inhibitory deficits and a delay in cortical maturation (Barkley, 1997 ; Lijffijt et al, 2005 ; Rubia et al, 2005 ; Shaw et al, 2007 , 2018 ), it follows that a larger imbalance between these brain systems is to be expected in this group (Sonuga-Barke, 2003 ), potentially making adolescents with ADHD unusually susceptible to peer influence.…”

Section: Introductionmentioning

confidence: 99%

Risk Taking by Adolescents with Attention-Deficit/Hyperactivity Disorder (ADHD): a Behavioral and Psychophysiological Investigation of Peer Influence

Dekkers

Popma

Sonuga‐Barke

et al. 2020

J Abnorm Child Psychol

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Adolescents with ADHD demonstrate increased risk-taking behavior (RTB) like substance abuse and dangerous traffic conduct. RTB in adolescence is more likely under peer influence. The current investigation (1) tests the hypothesis that adolescents with ADHD are particularly susceptible to such influence and (2) tests whether groups differed in autonomic reactivity to peer influence. Adolescent boys between 12 and 19 years with ( n = 81) and without ( n = 99) ADHD performed the Balloon Analogue Risk Task twice. In the peer condition, a highly credible virtual peer manipulation that encouraged risk taking was added, in the solo condition this was absent. Autonomic reactivity was indexed by heart rate (HR), pre-ejection period (PEP) and respiratory sinus arrhythmia (RSA). All adolescents engaged in more risk taking in the peer condition relative to solo condition. Autonomic differences between groups were only found on PEP: a stronger sympathetic response to peer influence was observed in typically developing adolescents relative to adolescents with ADHD. Increased physiological stress (as indexed by PEP) in the peer relative to the solo condition predicted peer-induced risk taking in all adolescents. We conclude that susceptibility to peer influence is not exaggerated in ADHD but rather reflects a general tendency of adolescents. As adolescents experiencing peer influence as stressful are most susceptible to peer influence, we suggest that increasing resistance to peer influence may be an important treatment aim for these adolescents specifically. Electronic supplementary material The online version of this article (10.1007/s10802-020-00666-z) contains supplementary material, which is available to authorized users.

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A multicohort, longitudinal study of cerebellar development in attention deficit hyperactivity disorder

Cited by 39 publications

References 47 publications

Characterizing neuroanatomic heterogeneity in people with and without ADHD based on subcortical brain volumes

Characterizing neuroanatomic heterogeneity in people with and without ADHD based on subcortical brain volumes

ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries

Risk Taking by Adolescents with Attention-Deficit/Hyperactivity Disorder (ADHD): a Behavioral and Psychophysiological Investigation of Peer Influence

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