A multicomponent, solvent-free, one-pot synthesis of benzoxanthenones catalyzed by HY zeolite: their anti-microbial and cell imaging studies

A Green and Solvent Free Protocol for the Synthesis of Bioactive Tetrahydrobenzo[C]Xanthene-8-Ones Using Novel Ionic Liquid L-Pyrrolidine-2-Carboxylic Acid Sulfate (LPCAS)

“…Moreover, the existing methods have not been conceded for the synthesis of tetrahydrobenzo[c]xanthene-8-ones from 1-naphthol because the electron density at 2-position of 1-naphthol is not sufficient for the formation of corresponding ortho-Quinone Methides (o-QMs). As per our knowledge, only three articles which involve the use of proline triflate [17], CAN [18] and Zeolite [19] Taking to account the weakness of reported methods and to overcome these problems, we have developed the green protocol for efficient synthesis of tetrahydrobenzo[c]xanthenes-8-ones. Herein we used novel ionic liquid; L-pyrrolidine-2-carboxylic acid sulfate (LPCAS) as a catalyst for the synthesis of tetrahydrobenzo[c]xanthenes-8-one derivatives from 1-naphthol ( Scheme 1).…”

Natural Organic Acid as Green Catalyst for Xanthenones Synthesis: Methodology, Mechanism and Calcium Channel Blocking Activity

“…2 On the other hand, xanthenones (Figure 1), xanthone derivatives, are poorly explored regarding their biological properties, and described only for its anti-proliferative, 3,4 antiviral 5 and anti-microbial properties. 6 The literature describes the synthesis of xanthenones via a multicomponent reaction using a phenolic compound, an aldehyde, and a cyclic 1,3-dicarbonyl compound. 7 Many Lewis or Brönsted acids may be used as catalysts: calixarenes, 3 ceric ammonium nitrate, 4 polyethyleneglycol bound sulfonic acid, 5 Hy zeolite, 6 triflate proline, 8 tetrabutyl ammonium fluoride, 9 tri-methyl tetradecyl ammonium bromide, 10 sulfamic acid, 11 p-toluenesulfonic acid, 12 triphenylphosphinem-sulfonate/carbon tetrabromide, 13 phosphorus(V) oxide, cumbersome product isolation procedures.…”

“…6 The literature describes the synthesis of xanthenones via a multicomponent reaction using a phenolic compound, an aldehyde, and a cyclic 1,3-dicarbonyl compound. 7 Many Lewis or Brönsted acids may be used as catalysts: calixarenes, 3 ceric ammonium nitrate, 4 polyethyleneglycol bound sulfonic acid, 5 Hy zeolite, 6 triflate proline, 8 tetrabutyl ammonium fluoride, 9 tri-methyl tetradecyl ammonium bromide, 10 sulfamic acid, 11 p-toluenesulfonic acid, 12 triphenylphosphinem-sulfonate/carbon tetrabromide, 13 phosphorus(V) oxide, cumbersome product isolation procedures. 16 They also use expensive and/or detrimental metal precursors, 14,15,22 toxic catalysts, 11,14 and toxic organic solvents to perform the reaction or purify the product.…”

Natural phosphate as an efficient and green catalyst for synthesis of tetraketone and xanthene derivatives

“…They are commonly synthesized through the Knoevenagel condensation followed by Michael addition of carbonyl compounds to 1,3-cyclic diketones employing natural alumina [17], KF/Al 2 O 3 [18], alumina-sulfuric acid [19], Fe 3? -montmorillonite [20], mesoporous silica nanoparticles (MSN) adsorbed HBF 4 [21], silica boronsulfuric acid nanoparticles (SBSANs) [22], HY zeolite [23], SmCl 3 [24], tetrabutylammonium hydrogen sulfate (TBAHS) [25], nano Fe/NaY [26], anchored MnO 2 (P-MnO 2 ) [27], and cerium-impregnated-MCM-41 [28] as catalysts. Although each of these methods has its own benefits, some of them often endure one or more disadvantages.…”