A multidimensional approach to impulsivity changes in mild Alzheimer’s disease and control participants: Cognitive correlates

Rochat, Lucien; Billieux, Joël; Linden, Anne-Claude Juillerat Van der; Annoni, Jean‐Marie; Zekry, Dina; Gold, Gabriel; Linden, Martial Van der

doi:10.1016/j.cortex.2011.08.004

Cited by 36 publications

(48 citation statements)

References 64 publications

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“…A significant increase in urgency, lack of premeditation, and lack of perseverance in patients with TBI was observed when retrospectively compared with the preinjury condition by patients' significant others, corroborating previous findings obtained on patients with TBI or Alzheimer's disease (Rochat et al, , 2013. These significant changes on these dimensions of impulsivity are consistent with the executive impairments frequently described in these patients.…”

Section: Discussionsupporting

confidence: 80%

“…In contrast, lack of perseverance in the short version of the UPPS scale used in the current study more specifically focused on one aspect: difficulties in completing projects that one has started. Consequently, resistance to proactive interference may better capture items related to concentration and boredom susceptibility, whereas other cognitive mechanisms, such as sustained attention and set-shifting may constitute better candidates for predicting items that refer to completing the projects that one has started (Rochat et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

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How Inhibition Relates to Impulsivity after Moderate to Severe Traumatic Brain Injury

Rochat

Beni

Annoni

et al. 2013

J Int Neuropsychol Soc

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Impulsive behaviors and poor inhibition performances are frequently described in patients with traumatic brain injury (TBI). However, few studies have examined impulsivity and associated inhibition impairments in these patients. Twenty-eight patients with moderate to severe TBI and 27 matched controls performed a stop-signal task designed to assess prepotent response inhibition (the ability to inhibit a dominant or automatic motor response) in a neutral or emotional context and a recent negative task to assess resistance to proactive interference (the ability to resist the intrusion into memory of information that was previously relevant but has since become irrelevant). Informants of each patient completed a short questionnaire designed to assess impulsivity. Patients showed a significant increase in current urgency, lack of premeditation, and lack of perseverance when retrospectively compared with the preinjury condition. Group comparisons revealed poorer prepotent response inhibition and resistance to proactive interference performances in patients with TBI. Finally, correlation analyses revealed a significant positive correlation between urgency (the tendency to act rashly when distressed) and prepotent response inhibition in patients with TBI. This study sheds new light on the construct of impulsivity after a TBI, its related cognitive mechanisms, and its potential role in problematic behaviors described after a TBI. (JINS, 2013, 19, 890-898)

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Section: Discussionsupporting

confidence: 80%

Section: Discussionmentioning

confidence: 99%

How Inhibition Relates to Impulsivity after Moderate to Severe Traumatic Brain Injury

Rochat

Beni

Annoni

et al. 2013

J Int Neuropsychol Soc

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“…Indeed, as mentioned previously, apathy is related to a variety of psychological mechanisms, including not only cognitive impairments such as multitasking but also motivational, affective, and/or personal identity disturbances (Arnould et al, 2013). Consequently, it could be expected that low self-efficacy beliefs, poor effort mobilization, or poor reward sensitivity lead to apathetic manifestations (Dumont, Gervais, Fougeyrollas, & Bertrand, 2004;Rochat, Van der Linden, et al, 2013), which in turn gradually compromise the execution of multitasking. For instance, faced with a complex everyday situation, people with low self-efficacy beliefs regarding their cognitive abilities may be passive and use avoidance coping because the goal appears unreachable (Finset & Andersson, 2000); this behaviour may then lead to poor performance in a multitasking situation.…”

Section: Discussionmentioning

confidence: 97%

“…The variable retained was the intra-individual coefficient of variation (ICV; see Stuss, Murphy, Binns, & Alexander, 2003) of RTs, computed by dividing the standard deviation by the mean RT, as a measure of sustained attention. Sustained attention difficulties have recently been associated with a central aspect of diminished goal-directed behaviour, namely lack of perseverance (Rochat, Billieux, et al, 2013).…”

Section: Simple Reaction Taskmentioning

confidence: 99%

Does multitasking mediate the relationships between episodic memory, attention, executive functions and apathetic manifestations in traumatic brain injury?

Arnould

Rochat

Dromer

et al. 2016

Journal of Neuropsychology

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Apathy is frequently described in patients with traumatic brain injury (TBI); its negative consequences particularly affect functional independence. Among apathetic manifestations, lack of initiative and lack of interest have mainly been associated with cognitive impairments. However, few studies have been conducted to precisely identify the underlying cognitive processes. Our aims were (1) to determine the best predictor of apathy from among several cognitive processes, including episodic memory and attention/executive mechanisms and multitasking, and (2) to examine to what extent multitasking could mediate the relationships between specific cognitive processes and lack of initiative/interest. Seventy participants (34 patients with TBI matched with 36 control participants) were given a questionnaire to assess anxio-depressive symptoms, four tasks to assess specific cognitive processes, and one task to assess real-life multitasking. Participants' relatives completed an apathy questionnaire. Multitasking, as assessed by the number of goals not achieved, was the only significant predictor of apathetic manifestations. In addition, the mediation analyses revealed that multitasking performance mediated the relationships between verbal episodic memory and lack of initiative/interest, whereas executive and attentional functions were only indirectly related to lack of initiative/interest due to their significant impacts on multitasking. These results shed new light on the aetiology of apathetic manifestations in patients with TBI, indicating how specific cognitive deficits are expressed in real-life multitasking, and consequently, how they may lead to the development and/or maintenance of apathetic manifestations.

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“…There were too few tissue samples (n = 7) in our study to perform correlational analyses, but there was a wide range of LC-MRI contrast within and across samples that appeared unrelated to age. Cognitive data were not available for our samples, but the high variability in LC-MRI contrast indicates that future studies could characterize the extent to which LC-MRI contrast predicts the early executive function symptoms in people with pre-clinical Alzheimer’s or Parkinson’s disease (Saunders and Summers, 2011; Salmon, 2012; Rochat et al, 2013), and the extent to which LC-MRI can serve as a biomarker for such disorders (Hampel et al, 2010). …”

Section: Discussionmentioning

confidence: 99%

Histologic validation of locus coeruleus MRI contrast in post-mortem tissue

et al. 2015

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The locus coeruleus (LC) noradrenergic system regulates arousal and modulates attention through its extensive projections across the brain. LC dysfunction has been implicated in a broad range of neurodevelopmental, neurodegenerative and psychiatric disorders, as well as in the cognitive changes observed during normal aging. Magnetic resonance imaging (MRI) has been used to characterize the human LC (elevated contrast relative to surrounding structures), but there is limited understanding of the factors underlying putative LC contrast that are critical to successful biomarker development and confidence in localizing nucleus LC. We used ultra-high-field 7 T magnetic resonance imaging (MRI) to acquire T1-weighted microscopy resolution images (78 μm in-plane resolution) of the LC from post-mortem tissue samples. Histological analyses were performed to characterize the distribution of tyrosine hydroxylase (TH) and neuromelanin in the scanned tissue, which allowed for direct comparison with MR microscopy images. Our results indicate that LC-MRI contrast corresponds to the location of neuromelanin cells in LC; these also correspond to norepinephrine neurons. Thus, neuromelanin appears to serve as a natural contrast agent for nucleus LC that can be used to localize nucleus LC and may have the potential to characterize neurodegenerative disease.

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A multidimensional approach to impulsivity changes in mild Alzheimer’s disease and control participants: Cognitive correlates

Cited by 36 publications

References 64 publications

How Inhibition Relates to Impulsivity after Moderate to Severe Traumatic Brain Injury

How Inhibition Relates to Impulsivity after Moderate to Severe Traumatic Brain Injury

Does multitasking mediate the relationships between episodic memory, attention, executive functions and apathetic manifestations in traumatic brain injury?

Histologic validation of locus coeruleus MRI contrast in post-mortem tissue

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