A multidisciplinary approach to squamous cell carcinomas of the head and neck: what is new?

Abstract

Major advances derived from the strategic use of different treatment and diagnostic modalities. The importance of a multidisciplinary team and knowledge in the approach of this disease should be stressed. Today, a multidisciplinary diagnostic and treatment philosophy is the tool to guarantee the best treatment plan definition, to prevent and relieve treatment adverse effects with the ultimate goal to improve survival.

Stable gene-silence of Kif2a synergistic with 5-fluorouracil suppresses oral tongue squamous cell carcinoma growth in vitro and in vivo

“…5 A multidisciplinary approach, including induction chemotherapy, concurrent chemotherapy and radiotherapy, is currently widely used for the treatment of advanced and/or metastatic forms of SCCOT. 2,3,11 Recently, a targeted molecular therapy has been reported to greatly improve prognoses of this malignant disease, e.g., Cetuximab, a monoclonal antibody of EGFR. 12,13 However, more potential biological targets for the treatment and therapy of SCCOT need to be explored.…”

“…In recent years, a multidisciplinary approach to SCCOT has begun to offer many clinical benefits mainly due to the addition of chemotherapy to radiotherapy. 2,3 Nevertheless, the severity of toxicity and the side-effects of radiochemotherapy remain major obstacles during treatment of SCCOT. 2 Currently, molecular targeted interventions in preclinical and clinical settings have become important for the treatment of SCCOT.…”

“…2,3 Nevertheless, the severity of toxicity and the side-effects of radiochemotherapy remain major obstacles during treatment of SCCOT. 2 Currently, molecular targeted interventions in preclinical and clinical settings have become important for the treatment of SCCOT. For instance, the use of inhibitors of epidermal growth factor receptor (EGFR) or its monoclonal antibodies (cetuximab) has been demonstrated to significantly prolong patients' survival.…”

Multidisciplinary clinical approach to the management of head and neck cancer

“…The management of patients with head and neck cancer is considered complex and requires a multifaceted treatment strategies for a heterogeneous group of tumours P. J. Bradley (&) Emeritus Consultant ORL-HNS, Nottingham University Hospitals, Queens Medical Centre Campus, Nottingham NG7 2UH, UK e-mail: pjbradley@zoo.co.uk located in key anatomical, physiological and functionalsites, not only for diagnosis but also for immediate and long-term rehabilitation [13][14][15][16][17][18]. Case presentation at HnN MDT affects and changes the clinical staging and therefore improves outcomes in a significant number of patients and improves quality of survival [19][20][21].…”

Multidisciplinary Management of Locally Advanced SCCHN: Optimizing Treatment Outcomes

“…Given the complexity of managing patients with LA-SCCHN, a multidisciplinary team approach is essential [5,85]. Input from various professionals with expertise in SCCHN (Table 4) is needed from the earliest phases of care to ensure appropriate diagnosis and assessment of baseline characteristics, risk factors, and prognosis [5].…”