“…Between 2012–2018, our Bridges to the Future study team prospectively followed 1,383 adolescents (10–16 years at study enrollment, who lost one or both parents to AIDS), across 48 primary schools in Uganda, to evaluate the efficacy and cost-effectiveness of a family-based economic empowerment intervention (EEI) comprising of child development accounts, financial literacy training, family income generating activities and peer mentorship. Our findings show short-term success with reduction in multidimension poverty incidence ( b −0.107, SE = 0.034, p<0.001) [ 9 ], improving self-related health (B = 0.25, 95% CI = 0.06–0.43) and emotional well-being, including lowered depression (B = -0.28, 95% CI = -0.43–0.125), hopelessness (B = 0.05, 95% CI = –0.11, 0.21), improved self-concept (B = 0.26, 95% CI 0.09–0.44), and adherence self-efficacy (B = 0.26, 95% CI = 0.09–0.43); reduced self-reported sexual risk-taking behaviors (B = 0.05, 95% CI = –0.11, 0.21) [ 10 , 11 ]; and positive educational outcomes among intervention participants, including better academic performance ( b = −3.78, 95% CI = −4.92, −2.64, p ≤ 0.001) and higher odds of transitioning to post primary education (OR = 1.66, 95% CI = 1.28, 2.18, p ≤ 0.001) [ 9 – 12 ]. However, critical questions related to the longitudinal impact of economic empowerment on HIV prevention and engagement in care among YPoAIDS remain.…”