A multifunctional antibacterial coating on bone implants for osteosarcoma therapy and enhanced osteointegration

Zhang, Guannan; Wu, Zhuangzhuang; Yang, Yongqiang; Shi, Jing; Lv, Jia; Fang, Yi; Shen, Zhen; Lv, Zhi; Li, Pengcui; Yao, Xiaohong; Chen, Weiyi; Wei, Xiaochun; Chu, Paul K.; Zhang, Xiangyu

doi:10.1016/j.cej.2021.131155

Cited by 37 publications

(36 citation statements)

References 89 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For instance, with laser power of >1 W/cm 2 , both scaffolds can reach temperature of >45 °C (i.e., therapeutic window for cancer therapy) within 50 s under ambient condition, a temperature change that is much faster than other similar systems. 37 The curve then plateaus, indicating stabilization of the temperature with time. Further increasing the NIR laser power can accelerate the heating process (e.g., reaches 45 °C within 25 s for 1.5 W/ cm 2 ).…”

Section: ■ Results and Discussionmentioning

confidence: 97%

“…In contrast, the scaffold chemical composition does not seem to have significant influence on the photothermal response. For instance, with laser power of >1 W/cm 2 , both scaffolds can reach temperature of >45 °C (i.e., therapeutic window for cancer therapy) within 50 s under ambient condition, a temperature change that is much faster than other similar systems . The curve then plateaus, indicating stabilization of the temperature with time.…”

Section: Results and Discussionmentioning

confidence: 99%

See 1 more Smart Citation

3D Printed Multifunctional Ti₆Al₄V-Based Hybrid Scaffold for the Management of Osteosarcoma

et al. 2021

View full text Add to dashboard Cite

Osteosarcoma is a challenging bone disease which is commonly associated with critically sized bone defects and cancer recurrence. Here, we designed and developed a multifunctional, hierarchical structured bone scaffold which can meet the demanding requirements for osteosarcoma management. The 3D printed Ti6Al4V scaffold with hydrothermally induced TiO2/TiP coating can offer a unique photothermal conversion property for in vitro bone cancer ablation. The scaffold is also infused with drug-laden gelatin/hydroxyapatite nanocomposite, which provides the ideal porous structure for cell adhesion/bone ingrowth and promotes bone regeneration. The scaffold has been thoroughly characterized by SEM/EDX, TEM, XPS, XRD, TGA, and UV–vis, and its in vitro bone cancer ablation efficiency has been validated using MG-63 cells. The hybrid scaffold showed excellent biocompatibility, and its osteointegration function has been demonstrated using an animal model.

show abstract

Section: ■ Results and Discussionmentioning

confidence: 97%

Section: Results and Discussionmentioning

confidence: 99%

3D Printed Multifunctional Ti₆Al₄V-Based Hybrid Scaffold for the Management of Osteosarcoma

et al. 2021

View full text Add to dashboard Cite

show abstract

“…The collagen in the coating was shown to promote the adhesion and proliferation of osteoblasts. Zhang et al prepared a titanium dioxide nano-shovel/quercetin/ l -arginine coating and doped ytterbium (Yb) and erbium (Er) on the TiO 2 nano-shovel array ( Zhang et al, 2022 ). Under near-infrared II light irradiation, Yb and Er promoted the production of ROS, which could kill bacteria.…”

Section: Prevention Of Aseptic Implant Looseningmentioning

confidence: 99%

Multifunctional Coatings of Titanium Implants Toward Promoting Osseointegration and Preventing Infection: Recent Developments

et al. 2021

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Titanium and its alloys are dominant material for orthopedic/dental implants due to their stable chemical properties and good biocompatibility. However, aseptic loosening and peri-implant infection remain problems that may lead to implant removal eventually. The ideal orthopedic implant should possess both osteogenic and antibacterial properties and do proper assistance to in situ inflammatory cells for anti-microbe and tissue repair. Recent advances in surface modification have provided various strategies to procure the harmonious relationship between implant and its microenvironment. In this review, we provide an overview of the latest strategies to endow titanium implants with bio-function and anti-infection properties. We state the methods they use to preparing these efficient surfaces and offer further insight into the interaction between these devices and the local biological environment. Finally, we discuss the unmet needs and current challenges in the development of ideal materials for bone implantation.

show abstract

“…With the convergence of material science and biology, a combination of surface modification and drug delivery systems can be employed to tackle the above mentioned complications. The electrochemical anodizing is a prevalent process among surface modifications that constructs nanotube arrays (TON) on titanium substrates 26 – 29 . TON arrays have beneficial properties including hosting a vast range of drugs and higher biocompatibility due to their highly porous nanostructures.…”

Section: Introductionmentioning

confidence: 99%

“…TON arrays have beneficial properties including hosting a vast range of drugs and higher biocompatibility due to their highly porous nanostructures. Moreover, their fabrication is low cost and simple 29 – 33 . The main disadvantage of TON arrays as drug nano-reservoirs is uncontrollable drug release behavior that may cause toxicity in the implant site.…”

Section: Introductionmentioning

confidence: 99%

Effect of electrochemical oxidation and drug loading on the antibacterial properties and cell biocompatibility of titanium substrates

Nowruzi

Imani

Faghihi

2022

Sci Rep

View full text Add to dashboard Cite

A combination of $${\text{ TiO}}_{2}$$ TiO 2 nanotube array (TON) and controlled drug release system is employed to provide enhanced surface properties of titanium implants. Electrochemical anodization process is used to generate TON for introducing, vancomycin, an effective antibacterial drug against Staphylococcusaureus. TON loaded vancomycin is then coated with a number of layers of 10% gelatin using spin coating technique. The gelatin film is reinforced with graphene oxide (GO) nanoparticles to improve the surface bioactivity. The surface of the samples is characterized by field emission electron microscopy (FESEM), energy-dispersive X-ray spectroscopy (EDS), and contact angle measurement. The results illustrate that the TON was constructed and vancomycin molecules are successfully loaded. The drug release study shows that the amount of released vancomycin is controlled by the thickness of gelatin layers. With an increase in gelatin film layers from 3 to 7, the release of vancomycin in the burst release phase decreased from 58 to 31%, and sustained release extended from 10 to 17 days. The addition of GO nanoparticles seems to reduce drug release in from 31 to 22% (burst release phase) and prolonged drug release (from 17 to 19 days). MTT assay indicates that samples show no cytotoxicity, and combination of GO nanoparticles with gelatin coating could highly promote MG63 cell proliferation. Soaking the samples in SBF solution after 3 and 7 days demonstrates that hydroxy apatite crystals were deposited on the TON surface with GO-gelatin coating more than surface of TON with gelatin. Moreover, based on the results of disc diffusion assay, both samples (loaded with Vancomycin and coated with gelatin and gelatin-GO) with the inhibition zones equaled to 20 mm show effective antibacterial properties against S. aureus. The evidence demonstrates that titania nanotube loaded with vancomycin and coated with gelatin-GO has a great potential for general applicability to the orthopedic implant field.

show abstract

A multifunctional antibacterial coating on bone implants for osteosarcoma therapy and enhanced osteointegration

Cited by 37 publications

References 89 publications

3D Printed Multifunctional Ti₆Al₄V-Based Hybrid Scaffold for the Management of Osteosarcoma

3D Printed Multifunctional Ti₆Al₄V-Based Hybrid Scaffold for the Management of Osteosarcoma

Multifunctional Coatings of Titanium Implants Toward Promoting Osseointegration and Preventing Infection: Recent Developments

Effect of electrochemical oxidation and drug loading on the antibacterial properties and cell biocompatibility of titanium substrates

Contact Info

Product

Resources

About

A multifunctional antibacterial coating on bone implants for osteosarcoma therapy and enhanced osteointegration

Cited by 37 publications

References 89 publications

3D Printed Multifunctional Ti6Al4V-Based Hybrid Scaffold for the Management of Osteosarcoma

3D Printed Multifunctional Ti6Al4V-Based Hybrid Scaffold for the Management of Osteosarcoma

Multifunctional Coatings of Titanium Implants Toward Promoting Osseointegration and Preventing Infection: Recent Developments

Effect of electrochemical oxidation and drug loading on the antibacterial properties and cell biocompatibility of titanium substrates

Contact Info

Product

Resources

About

3D Printed Multifunctional Ti₆Al₄V-Based Hybrid Scaffold for the Management of Osteosarcoma

3D Printed Multifunctional Ti₆Al₄V-Based Hybrid Scaffold for the Management of Osteosarcoma