A multifunctional biomedical patch based on hyperbranched epoxy polymer and MXene

A robust epoxy nanocomposite with iron oxide decorated cellulose nanofiber as a sustained drug delivery vehicle for antibacterial drugs

“…Recently Yang et al fabricated an antibacterial patch derived from hyperbranched epoxy that was loaded with curcumin. 19 They have analysed the antibacterial properties of the patch along with other parameters but remained silent on the curcumin release profiles of the patches. Considering these facts, the AC loaded nanocomposites have been cured at RT so as to achieve moderate crosslinking and allow permeation of solvent media through the material.…”

“…Implantation of metal-based devices inside the living body is often associated with post-surgical infections that have been proven many times to be fatal. 19 Applying infection-resistant coatings that can release antimicrobial particles or drugs loaded in them and simultaneously degrade in vivo after completion of their service can provide a prolific solution to such problems. Epoxy resin, a dominating candidate in the coating-based industries, has been rarely explored as a drug carrier coating for metallic implants or other metal-based apparatus used in biomedical applications.…”

“…In a recent study by Zou et al, a hyperbranched epoxy was loaded with curcumin and MXene to prepare bactericidal patches. 19 The study focused on self-healing, and shape memory attributes as well as curcumin-induced antibacterial activity of the patches but remained silent on its release profiles. 19 Considering the above discussion, the agenda of this work was to fabricate a bio-derived epoxy-based mechanically strong, biocompatible nanocomposite system using an innocuous nanohybrid made up of IONPs grown over CNFs, that can be tuned for different propitious applications.…”

“…19 The study focused on self-healing, and shape memory attributes as well as curcumin-induced antibacterial activity of the patches but remained silent on its release profiles. 19 Considering the above discussion, the agenda of this work was to fabricate a bio-derived epoxy-based mechanically strong, biocompatible nanocomposite system using an innocuous nanohybrid made up of IONPs grown over CNFs, that can be tuned for different propitious applications. Primarily, the IONP@CNF nanohybrid was prepared using a facile and sustainable route, by growing IONPs in situ over the surface of CNFs at room temperature (RT) under an aerobic environment.…”

Recent Advances in MXene/Epoxy Composites: Trends and Prospects

“…Furthermore, they present a highly efficient photothermal effect and more powerful antibacterial activity than other two-dimensional nanoparticles, such as graphene. Zou et al reported the fabrication of multifunctional MXene/hyperbranched epoxy biomedical patches [ 96 ]. The hybrid patch was based on Ti 3 C 2 T x MXenes, curcumin (cur)—which has multifunctional therapeutic properties—and epoxy-capped and phenylboronic-acid-decorated hyperbranched polyether (EHBPE-PBA), which was obtained through an epoxy/thiol curing chemistry.…”