A multifunctional chitosan composite aerogel based on high density amidation for chronic wound healing

Yao, Chung-Chen Jane; Xiang, Yu; Zhang, Hongmei; Zhu, Tonghe; Chen, Sihao; Li, Jun; Du, Juan; Yan, Xiaoyu

doi:10.1016/j.carbpol.2023.121248

Cited by 13 publications

(5 citation statements)

References 45 publications

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“…These dressings present notable benefits, such as low density, high porosity, and a large surface area. Due to these inherent characteristics, aerogels facilitate the rapid intake of a substantial volume of exudate, sustain a hydrated environment, enable gas diffusion, and concomitantly provide commendable thermal insulation for maintaining physiological temperature [2]. Although aerogels show promise for utilization in wound treatment, challenges such as characterization of optical and thermal characteristics of a single aerogel fibre, manufacturing single fibre devices, and scalability need to be overcome [101].…”

Section: Aerogelsmentioning

confidence: 99%

“…Wounds have plagued patients for millennia, imposing a substantial burden on their carers, thus earning its designation as the 'silent epidemic' [1]. Approximately 4 million cutaneous wounds have been documented to occur annually in affluent countries, with the number in developing nations in ascendance [2]. Skin injury compromises the integrity of the skin's framework, leading to a wound healing process that is characterized by a well-coordinated series of cellular and molecular reactions that aim to recuperate or replace the injured tissue [3].…”

Section: Introductionmentioning

confidence: 99%

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Hydrogels and Wound Healing: Current and Future Prospects

Gounden,

Singh

2024

Gels

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The care and rehabilitation of acute and chronic wounds have a significant social and economic impact on patients and global health. This burden is primarily due to the adverse effects of infections, prolonged recovery, and the associated treatment costs. Chronic wounds can be treated with a variety of approaches, which include surgery, negative pressure wound therapy, wound dressings, and hyperbaric oxygen therapy. However, each of these strategies has an array of limitations. The existing dry wound dressings lack functionality in promoting wound healing and exacerbating pain by adhering to the wound. Hydrogels, which are commonly polymer-based and swell in water, have been proposed as potential remedies due to their ability to provide a moist environment that facilitates wound healing. Their unique composition enables them to absorb wound exudates, exhibit shape adaptability, and be modified to incorporate active compounds such as growth factors and antibacterial compounds. This review provides an updated discussion of the leading natural and synthetic hydrogels utilized in wound healing, details the latest advancements in hydrogel technology, and explores alternate approaches in this field. Search engines Scopus, PubMed, Science Direct, and Web of Science were utilized to review the advances in hydrogel applications over the last fifteen years.

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Section: Aerogelsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Hydrogels and Wound Healing: Current and Future Prospects

Gounden,

Singh

2024

Gels

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show abstract

“…6). 92,93,250,251 Biological macromolecules provide flexible polymer chains and more cross-linked and branching structures, which can increase intermolecular interactions and thereby improve the strength and toughness of BAs. They also endow the composite aerogels with biocompatibility and degradability, characteristics highly sought after by researchers across cross-disciplines encompassing chemistry, biology, and material science.…”

Section: Structure Design and Functional Tailoringmentioning

confidence: 99%

“…231,232 These aerogels also have excellent biocompatibility and biodegradability, holding significant potential for future applications in wound dressings. 214–216 Typically, Chen et al used dopamine-grafted gelatin and CS as matrix, 250 safe N -hydroxysuccinimide and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride as crosslinking agents to create vascular endothelial growth factor loaded aerogels through a freeze-drying process. The chemical reaction process is shown in Fig.…”

Section: Applicationmentioning

confidence: 99%

Renewable biomass-based aerogels: from structural design to functional regulation

Chen,

Yu,

Gao

et al. 2024

Chem. Soc. Rev.

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“…As one of the most abundant biomass materials, chitosan (CS) is rich in hydroxyl and amino groups, which can provide a large number of reaction sites [12], and is widely used in the preparation of biomass aerogels. CS-based materials are currently prevalent in various fields including wastewater treatment [13], antimicrobial activities [14,15], food preservation [16], sound absorption [17], reinforcement filler [18,19], drug delivery [20], oil spill cleanup [21,22], healing wounds [23,24], etc. However, due to the poor mechanical properties and unstable structure of biomass aerogels [25], CS-based aerogels have disadvantages.…”

Section: Introductionmentioning

confidence: 99%

Polyhedral Oligomeric Sesquioxane Cross-Linked Chitosan-Based Multi-Effective Aerogel Preparation and Its Water-Driven Recovery Mechanism

Liu,

Ma,

Shen

et al. 2024

Gels

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The use of environmentally friendly and non-toxic biomass-based interfacial solar water evaporators has been widely reported as a method for water purification in recent years. However, the poor stability of the water transport layer made from biomass materials and its susceptibility to deformation when exposed to harsh environments limit its practical application. To address this issue, water-driven recovery aerogel (PCS) was prepared by cross-linking epoxy-based polyhedral oligomeric silsesquioxane (EP-POSS) epoxy groups with chitosan (CS) amino groups. The results demonstrate that PCS exhibits excellent water-driven recovery performance, regaining its original volume within a very short time (1.9 s) after strong compression (ε > 80%). Moreover, PCS has a water absorption rate of 2.67 mm s−1 and exhibits an excellent water absorption capacity of 22.09 g g−1 even after ten cycles of absorption-removal. Furthermore, a photothermal evaporator (PCH) was prepared by loading the top layer with hydrothermally reacted tannins (HAs) and Zn2+ complexes. The results indicate that PCH achieves an impressive evaporation rate of 1.89 kg m−2 h−1 under one sun illumination. Additionally, due to the antimicrobial properties of Zn2+, PCH shows inhibitory effects against Staphylococcus aureus and Escherichia coli, thereby extending the application of solar water evaporators to include antimicrobial purification in natural waters.

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A multifunctional chitosan composite aerogel based on high density amidation for chronic wound healing

Cited by 13 publications

References 45 publications

Hydrogels and Wound Healing: Current and Future Prospects

Hydrogels and Wound Healing: Current and Future Prospects

Renewable biomass-based aerogels: from structural design to functional regulation

Polyhedral Oligomeric Sesquioxane Cross-Linked Chitosan-Based Multi-Effective Aerogel Preparation and Its Water-Driven Recovery Mechanism

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